Abstract
Biological activity is closely tied to chirality and control of the enantioselectivity in the synthesis of fine chemicals is of increasing interest [1-3]. Although a large number of enantioselective reductions of prochiral compounds are reported in the literature, no catalytic enantioselective reductions of disubstituted aromatics, which could lead to valuable alicyclic compounds have been reported yet. To reach this goal, two approaches were tried in the present work, namely enantioselective and diastereoselective heterogeneous catalysis.
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References
Asymmetric Synthesis, Vol 5: Chiral Catalysis, (J.D. Morrison Ed.), Academic Press (1985).
H.U. Blaser, Tetrahedron: Asymmetry, 2(9), 843 (1991).
R.A. Sheldon, Chirotechnology, Industrial Synthesis of Optically Active Compounds, Marcel Dekker (1993).
Y. Izumi, Advances Catal, 32, 215 (1983).
H.U. Blaser, H.P. Jalett, D.M. Monti, J.F. Reber and J.T. Wehrli in Heterogeneous Catalysis and Fine Chemicals, (M. Guisnet Ed.), Elsevier, 153 (1988).
P. Drognat-Landre, D. Richard, P. Gallezot and M. Lemaire, J. Mol Cat., 78, 257 (1993).
K. Nasar, F. Fache, M. Lemaire, M. Besson and P. Gallezot, J. Mol Cat., 87, 107 (1994).
J. Crosby, Tetrahedron, 47(27), 4789 (1991).
K. Harada, Asymmetric Synthesis, Vol 5, 345 (1985).
T. Munegumi, M. Fujita, T. Maruyama, S. Shiono, M. Takasaki and K. Harada, Bull. Chem. Soc. Jpn., 60, 249 (1987).
T. Munegumi, T. Maruyama, M. Takasaki and K. Harada, Bull. Chem. Soc. Jpn., 63, 1832 (1990).
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Nasar, K., Besson, M., Gallezot, P., Fache, F., Lemaire, M. (1995). Enantio- and Diastereoselective Reduction of Disubstituted Aromatics. In: Jannes, G., Dubois, V. (eds) Chiral Reactions in Heterogeneous Catalysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1909-6_15
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DOI: https://doi.org/10.1007/978-1-4615-1909-6_15
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