Asymmetric Hydrogenation of Ethyl Pyruvate Using Ptcontaining Zeolites Modified With (-)-Cinchonidine

  • W. Reschetilowski
  • U. Böhmer
  • J. Wiehl


Platinum loaded, (-)-cinchonidine modified zeolites of the types Y, ZSM-35, β and ZSM-5 manifest high catalytic activity for the asymmetric hydrogenation of ethyl pyruvate to ethyl lactate. The catalysts based on Y and ZSM-35 zeolites show the highest enantioselectivity. To obtain the highest reaction rates and the optical yields the Pt content should be around 5 wt%

Enantiomeric excess is strongly influenced by the type of solvent used and can be raised from 60% ee. to 80% ee. merely by varying the solvents.


Enantiomeric Excess Initial Reaction Rate High Reaction Rate Ethyl Pyruvate Optical Yield 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    S. Akabori, Y. Izumi, Y. Fujii and S. Sakurai, J. Chem. Soc. Japan, Pure Chem. Sec. 77 (1956) 1374.Google Scholar
  2. [2]
    I. Yasumori, M. Yokozeki and Y. Inoue, Faraday Disc. Chem. Soc. 72 (1981), 385.CrossRefGoogle Scholar
  3. [3]
    T. Osawa, T. Harada and A. Tai, J. Catal. 121 (1990) 7.CrossRefGoogle Scholar
  4. [4]
    Y. Orito, S. Imai, S. Niwa and Nguyen G.-H., J. Synth. Org. Chem. Jpn. 37 (1979) 173.CrossRefGoogle Scholar
  5. [5]
    J.T. Wehrli, A. Baiker, D.M. Monti, H.U. Blaser and H.P. Jalett, J. Mol. Catal. 57 (1989) 245.CrossRefGoogle Scholar
  6. [6]
    H.U. Blaser, H.P. Jalett and J. Wiehl, J. Mol. Catal. 68 (1991) 215.CrossRefGoogle Scholar
  7. [7]
    J.L. Margitfalvi, B. Minder, E. Talás, L. Botz and A. Baiker, Stud. Surf. Sci. Catal. 75C (1993) 2471.CrossRefGoogle Scholar
  8. [8]
    R.M. Dessau, US Patent 4 554 262 (1985).Google Scholar
  9. [9]
    J. Weitkamp, Stud. Surf. Sci. Catal. 65 (1991) 21.CrossRefGoogle Scholar
  10. [10]
    A. Corma, M. Iglesias, C. del Pino, and F. Sánchez, Stud. Surf. Sci. Catal. 75C (1993) 2293.CrossRefGoogle Scholar
  11. [11]
    W. Reschetilowski, U. Böhmer, Proc. DGMK-Conference “Selective Hydrogenations and Dehydrogenations”, Kassel, Germany, 1993, p. 275.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • W. Reschetilowski
    • 1
  • U. Böhmer
    • 1
  • J. Wiehl
    • 2
  1. 1.Karl-Winnacker-Institut der DECHEMA e.VFrankfurt am MainGermany
  2. 2.W.C. Heraeus GmbHHanauGermany

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