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Biosynthesis of Nitric Oxide

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Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

Abstract

In the past several years, the L-arginine/NO pathway has been recognized as part of a wide-spread signal transducing system, involved in a variety of biological processes. NO is generated in a Ca2+-dependent enzymatic reaction from the amino acid L-arginine. As a potent activator of soluble guanylyl cyclase (sGC), NO exerts many of its effects through intracellular accumulation of the nucleotide cycic GMP (cGMP), which acts on multiple intracellular target proteins. In the the first part of this article, a brief synopsis will be given on enzymology of sGC related to its stimulation by NO, and in the second, more comprehensive part current knowledge about the mechanisms and regulation of NO biosynthesis will be reviewed.

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  1. Institut für Pharmakologie und Toxikologie, Universität Graz, Universitätsplatz 2, Graz, Austria

    Bernd Mayer

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  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Ben Avi Weissman , Nahum Allon  & Shlomo Shapira ,  & 

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Mayer, B. (1995). Biosynthesis of Nitric Oxide. In: Weissman, B.A., Allon, N., Shapira, S. (eds) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1903-4_4

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