The Effects of Sodium Nitroprusside and L-Glutamate on the Regulation of the Cytoskeletal Associated Protein Tau in Primary Cultured Neurons from Rat
Some of the hallmarks of neurodegenerative diseases such as Alzheimer’s Disease are the presence of paired helical filaments (PHF) associated with neurofibrillary tangles and neuritic plaques in histological sections of brains of patients with Alzheimer’s Disease (1). Tau is a neuronal protein that associates with microtubules, i.e., microtubule associated protein or MAP (2). Tau promotes microtubule assembly and its phosphorylation may be important for axonal growth during development. However, hyperphosphorylated tau may polymerize and lead to aggregated forms that are associated with paired helical filaments (3). It is believed that hyperphosphorylated tau may participate in the pathogenesis of Alzheimer’s Disease and, perhaps, other neurodegenerative processes.
KeywordsNitric Oxide Sodium Nitroprusside Neuronal Degeneration Striatal Neuron Paired Helical Filament
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- 1.Alzheimer Disease. Eds., Terry, R.D., Katzman, R., and Bick, K.L. Raven Press, New York, New York,pp 198, 1994.Google Scholar
- 6.Murad, F. The nitric oxide signal transduction system (chapter in this monograph).Google Scholar
- 7.Ignarro, L.J., Lippton, H., Edward, J.D., Baricos, W.H., Hyman, A.L., Kadowitz, P.J., and Gruetter,C.A. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J. Pharmacol. Exp. Ther., 218:739–749, 1981.PubMedGoogle Scholar