Abstract
Extensive evidence accumulated over the past two decades has documented the existence of an inhibitory nervous system in the airways of most mammalian species, including man, that is neither adrenergic nor cholinergic. Because the neurotransmitter of this system has not been identified with certainty, the system continues to be referred to as the nonadrenergic noncholinergic (NANC) inhibitory system. Most recently, attention has been focused on nitirc oxide (NO) as a possible transmitter of NANC inhibitory responses in the airways. This paper will succinctly review relevant background information regarding the airway NANC inhibitory system as well as current evidence advocating or disputing a role for NO in NANC inhibitory nerve-mediated relaxation of airway smooth muscle. Results from our own laboratory will be integrated with data reported by other investigators in an effort to present the reader with a balanced perspective on this intriguing, yet controversial topic.
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References
Altiere, R.J., Diamond, L. and Thompson, D.C., 1994, Species variation in airway sensitivity to nitric oxide and nonadrenergic noncholinergic inhibitory nerve activation, Am. J. Resp. Crit. Care Med. 149:A594.
Bai, T.R. and Bramley, A.M., 1993, Effect of an inhibitor of nitric oxide synthase on neural relaxation of human bronchi. Am. J. Physiol. 264 (Lung Cell. Mol. Physiol. 8):L425.
Belvisi, M.G., Stretton, C.D., Miura, M., Verleden, G.M., Tadjkarimi, S., Yacoub, M.H. and Barnes, PJ., 1992, Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter. J. Appl. Physiol. 73:2505.
Dey, R.D., Mayer, B. and Said, S.I., 1993, Colocalization of vasoactive intestinal peptide and nitric oxide synthase in neurons of the ferret trachea. Neurosci. 54:839.
Diamond, L. and Altiere, R. J., 1988, Airway nonadrenergic noncholinergic inhibitory nervous system, in: “The Airways. Neural Control in Health and Discase,”M.A. Kaliner and P.J. Barnes, eds., Marcell Dekker, New York.
Diamond, L. and O’Donnell, M., 1980, A nonadrenergic vagal inhibitory pathway to feline airways. Science 208: 185.
Diamond, L., Lantta, J., Thompson, D.C. and Altiere, R.J., 1992, Nitric oxide synlhase inhibitors fail to affect cat airway nonadrenergic noncholinergic inhibitory (NANCI) responses. Am. Rev. Resp. Dis. 145:A382.
Dupuy, P.M., Shore, S.A., Drazen, J.M., Frostell, C., Hill, W.A. and Zapol, W.M., 1992, Bronchodilator action of inhaled nitric oxide in guinea pigs. J. Clin. Invest. 90:421.
Ellis, J.L. and Undem, BJ., 1992, Inhibition by L-NG-nitro-L-arginine of nonadrenergic-noncholinergic-mediated relaxations of human isolated central and peripheral airways. Am. Rev. Respir. Dis. 146:1543.
Fischer, A. Mundel, P., Mayer, B., Preissler, U., Philippin, B. and Kummer, W., 1993, Nitric oxide synthase in guinea pig lower airway innervation. Neurosci. Lett. 149:157.
Fisher, J.T., Anderson, J.W. and Waldron, M.A., 1993, Nonadrenergic noncholinergic neurotransmitter of feline trachealis: VIP or nitric oxide? J. Appl. Physiol. 74:31.
Gaston, B., Drazen, J.M., Jansen, A., Sugarbaker, D.A., Loscalzo, J., Richards, W. and Stamler, J.S., 1994a, Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. J. Pharmacol. Exp. Ther. 268:978.
Gaston, B., Drazen, J., Loscaizo, J. and Stamler, J.S., 1994b, The biology of nitrogen oxides in the airways. Am. J. Respir. Crit. Care Med. 149:538.
Grider, J.R., Murthy, K.S., Jin, J.-G. and Maklouf, G.M., 1992, Stimulation of nitric oxide from muscle cells by VIP: prejunctional enhancement of VIP release. Am. J. Physiol. 262:G774.
Hassall, C.J.S., Saffrey, M.J. and Burnstock, G., 1993, Expression of NADPH-diaphorase activity by guinea-pig paratracheal neurones. NeuroReport 4:49.
Hobbs, AJ., Tucker, J.F. and Gibson, A., 1991, Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions. Br. J. Pharmacol. 104:645.
Jansen, A., Drazen, J., Osborne, J.A., Brown, R., Loscaizo, J. and Stamler, J.S., 1992, The relaxant properties in guinea pig airways of S-nitrosothiols. J. Pharmacol. Exp. Ther. 261:154.
Kannan, M.S. and Johnson, D.E., 1992, Nitric oxide mediates the neural nonadrenergic, noncholinergic relaxation of pig tracheal smooh muscle. Am. J. Physiol. 262 (Lung Cell. Mol. Physiol. 2):L511.
Kobzik, L., Bredt, D.S., Lowenstein, CJ., Drazen, J., Gaston, B., Sugerbaker, D. and Stamler, J.S., 1993, Nitric oxide synthse in human and rat lung: immunocytochemical and histochemical localization. Am. J. Respir. Cell Mol. Biol. 9:371.
Li, C.G. and Rand, M.J., 1991, Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. Br. J. Pharmacol. 102:91.
McWilliam, P.N. and Gray, S.J., 1990, The innervation of tracheal smooth muscle in the ferret. J. Auton. Nerv. Syst. 30:233.
Satchell, D., 1982, Non-adrenergic, non-cholinergic nerves in mammalian airways: their function and the role of purines. Camp. Biochem. Physiol. 72C: 189.
Schuman, E.M. and Madison, D.V., 1991, A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science 254:1503.
Thompson, D.C., Lantta, J., Diamond, L. and Altiere, R.J., 1992, A nitric oxide synthase inhibitor modulates neural responses in guinea pig airways. Am. Rev. Resp. Dis. 145:A382.
Tucker, J.F., Brave, S.R., Charalambous, L., Hobbs, A.J. and Gibson, A., 1990, L-NG-nitro-arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea pig isolated tracheal smooth muscle. Br. J. Pharmacol.
Yu, M., Wang, Z., Robinson, N.E. and LeBlanc, P.H., 1994, Inhibitory nerve distribution and mediation of NANC relaxation by nitric oxide in horse airways. J. Appl. Physiol. 76:339.
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Diamond, L., Altiere, R.J., Lindsay, G., Thompson, D.C. (1995). The Role of Nitric Oxide in Nonadrenergic Noncholingergic Neural Relaxation of Mammalian Airway Smooth Muscle. In: Weissman, B.A., Allon, N., Shapira, S. (eds) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1903-4_14
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DOI: https://doi.org/10.1007/978-1-4615-1903-4_14
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