Abstract
Rickettsia conorii is an obligate, intracellular, gram-negative bacterium which causes Mediterranean spotted-fever. The encounter between rickettsia and macrophage can result either in the destruction of the cell due to rickettsial intracellular multiplication or in the destruction of the invasing bacterium. The anti-rickettsial activity of the macrophage can be stimulated in two modes. The first, by treating the macrophages with cytokines such as γ-interferon (γ-IFN). The other, destruction of rickettsiae within the macrophage cell can be facilitated by treating the rickettsiae with specific-antibodies prior to their engulfment by the macrophage (Winkler and Turco, 1993).
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© 1995 Springer Science+Business Media New York
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Keysary, A., Oron, C., Rosner, M., Weissman, B.A. (1995). The Involvement of L-Arginine-Nitric Oxide Pathway in the Anti-Rickettsial Activity of Macrophagelike Cells. In: Weissman, B.A., Allon, N., Shapira, S. (eds) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1903-4_12
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DOI: https://doi.org/10.1007/978-1-4615-1903-4_12
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