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Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide pp 93–101Cite as

Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog

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Abstract

The action of low doses of nitrovasodilators on coronary circulation is characterised by a selective dilatation of large conductance coronary arteries1,2,3, which is accompanied by a minimal effect on small coronary resistance vessels4,5,6,7. This ability of nitroderivatives to dilate selectively large coronary arteries, becomes of major importance when the capability of the conduit epicardial coronary arteries to dilate in response to increases in blood flow is impaired, as it happens after removal of coronary endothelium with angioplasty8 or in patients with atherosclerosis9,10. In those conditions, while the flow-dependent endothelium-mediated response is depressed, the endothelium-independent relaxing effect of nitravasodilators on large conduit coronary arteries remains effective. This has been confirmed in clinical studies, where the coronary vasospasm in anginal patients in which endothelium is likely not functional, has been effectively reversed by nitrovasodilators 11,12

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Author information

Authors and Affiliations

  1. Talfarmaco Research Center, Milano, Italy

    Jacques Mizrahi, Roberta Cereda, Marco Sardina, Gianni Gromo & Mario Bergamaschi

  2. Dept. of Internal Medicine, University of Minnesota, Minneapolis, USA

    Robert J. Bache

  3. Inst. of Applied Physiology, University of Freiburg, Germany

    Eberhard Bassenge

  4. Dept.of Pharmacology, Faculty of Medicine, Universit Paris-Sud, France

    Alain Berdeaux & Jean-Francois Giudicelli

  5. Dept. of Pharmacology, Nagasaki University, School of Medicine, Japan

    Akira Ueno

Authors
  1. Jacques Mizrahi
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  2. Robert J. Bache
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  3. Eberhard Bassenge
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  4. Alain Berdeaux
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  5. Jean-Francois Giudicelli
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  6. Akira Ueno
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  7. Roberta Cereda
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  8. Marco Sardina
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  9. Gianni Gromo
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  10. Mario Bergamaschi
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Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Ben Avi Weissman , Nahum Allon  & Shlomo Shapira ,  & 

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© 1995 Springer Science+Business Media New York

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Mizrahi, J. et al. (1995). Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog. In: Weissman, B.A., Allon, N., Shapira, S. (eds) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1903-4_10

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  • DOI: https://doi.org/10.1007/978-1-4615-1903-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5777-3

  • Online ISBN: 978-1-4615-1903-4

  • eBook Packages: Springer Book Archive

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