Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog

  • Jacques Mizrahi
  • Robert J. Bache
  • Eberhard Bassenge
  • Alain Berdeaux
  • Jean-Francois Giudicelli
  • Akira Ueno
  • Roberta Cereda
  • Marco Sardina
  • Gianni Gromo
  • Mario Bergamaschi


The action of low doses of nitrovasodilators on coronary circulation is characterised by a selective dilatation of large conductance coronary arteries1,2,3, which is accompanied by a minimal effect on small coronary resistance vessels4,5,6,7. This ability of nitroderivatives to dilate selectively large coronary arteries, becomes of major importance when the capability of the conduit epicardial coronary arteries to dilate in response to increases in blood flow is impaired, as it happens after removal of coronary endothelium with angioplasty8 or in patients with atherosclerosis9,10. In those conditions, while the flow-dependent endothelium-mediated response is depressed, the endothelium-independent relaxing effect of nitravasodilators on large conduit coronary arteries remains effective. This has been confirmed in clinical studies, where the coronary vasospasm in anginal patients in which endothelium is likely not functional, has been effectively reversed by nitrovasodilators 11,12


Left Anterior Descend Myocardial Blood Flow Coronary Blood Flow Coronary Stenosis Mean Blood Pressure 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Jacques Mizrahi
    • 1
  • Robert J. Bache
    • 2
  • Eberhard Bassenge
    • 3
  • Alain Berdeaux
    • 4
  • Jean-Francois Giudicelli
    • 4
  • Akira Ueno
    • 5
  • Roberta Cereda
    • 1
  • Marco Sardina
    • 1
  • Gianni Gromo
    • 1
  • Mario Bergamaschi
    • 1
  1. 1.Talfarmaco Research CenterMilanoItaly
  2. 2.Dept. of Internal MedicineUniversity of MinnesotaMinneapolisUSA
  3. 3.Inst. of Applied PhysiologyUniversity of FreiburgGermany
  4. 4.Dept.of Pharmacology, Faculty of MedicineUniversit Paris-SudFrance
  5. 5.Dept. of PharmacologyNagasaki University, School of MedicineJapan

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