Abstract
Neurotropic murine coronaviruses (MHV) provide an excellent animal model to study experimental modulation of the immune response to a viral pathogen with anti-idio-typic antibodies. It is known that among the various types of anti-idiotypic antibodies (anti-Id), those designated beta (β) or internal image can molecularly mimic the antigen and induce biological activities such as anti-viral protection and neutralization. We have recently shown that polyclonal non-internal image anti-idiotypic antibodies of the β-type could induce protective anti-coronavirus immunity1.
In the present study, a polyclonal anti-Id (Ab2) was induced against a neutralizing murine monoclonal antibody (MAbl), designated 5B170.11. Mice immunized with this affinity-purified rabbit Ab2α, a non-internal image antibody, were partially protected against lethal infection by the JHM strain of MHV. However, other polyclonal and monoclonal non-internal image Ab2 induced against another neutralizing MAbl, designated 4-11G.6, were not able to protect mice against lethal infection with the A59 strain of MHV.
These results demonstrate that anti-viral protection by altering the idiotypic network with non-internal image-bearing anti-idiotype reagents can be achieved even with some anti-Id of the α-type.
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Yu, M., Talbot, P.J. (1995). Induction of a Protective Immune Response to Murine Coronavirus with Non-Internal Image Anti-Idiotypic Antibodies. In: Talbot, P.J., Levy, G.A. (eds) Corona- and Related Viruses. Advances in Experimental Medicine and Biology, vol 380. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1899-0_27
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DOI: https://doi.org/10.1007/978-1-4615-1899-0_27
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