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Corona- and Related Viruses pp 109–111Cite as

Mouse Hepatitis Virus-Specific CD8+ Cytotoxic T Lymphocytes Induce Apoptosis in Their Target Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 380))

Abstract

CD8+ cytotoxic T lymphocytes (CTL) have been suggested to play an important role in virus clearance and development of demyelination during mouse hepatitis virus (MHV) infection in mice1. Production of antiviral cytokines such as γ-IFN and direct cytolysis of virus-infected cells have been considered to be the major role of CTL, but their precise mechanisms in MHV infection remain unclarified. We have previously established CTL line, P1 1D which specifically lyses cells infected with MHV, strain JHM (JHMV)2 and saves mice from lethal JHMV infection3. To clarify the detailed mechanism of CTL during MHV infection, we examined morphological changes of JHMV-infected target cells in vitro cocultured with anti-MHV CTL line, P1 1D.

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References

  1. Kyuwa, S., and S. A. Stohlman. Pathogenesis of a neurotrophic murine coronavirus, strain JHM in the central nervous system of mice. Semin. Virol. 1990. 1:273–280.

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  2. Yamaguchi, K., S. Kyuwa, K. Nagata, and M. Hayami. Establishment of cytotoxic T-cell clones specific for cells infected with mouse hepatitis virus. J. Virol. 1988. 62:2505–2507.

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  3. Yamaguchi, K., N. Goto, S. Kyuwa, M. Hayami, and Y. Toyoda. Protection of mice from a lethal coronavirus infection in central nervous system by adoptive transfer of virus-specific T cell clones. J. Neuroimmunol. 1991. 32:1–9.

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  4. Shibata, S., S. Kyuwa, S.-K. Lee, Y. Toyoda, and N. Goto. Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone. J. Virol. 1994. in press.

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Authors and Affiliations

  1. Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113, Japan

    Shinwa Shibata & Naoaki Goto

  2. Department of Animal Pathology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan

    Shigeru Kyuwa & Yutaka Toyoda

  3. Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa 252, Japan

    Kosaku Fujiwara

Authors
  1. Shinwa Shibata
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  2. Shigeru Kyuwa
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  3. Kosaku Fujiwara
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  4. Yutaka Toyoda
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  5. Naoaki Goto
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Editor information

Editors and Affiliations

  1. Armand-Frappier Institute, University of Québec, Laval, Québec, Canada

    Pierre J. Talbot

  2. The Toronto Hospital, University of Toronto, Toronto, Ontario, Canada

    Gary A. Levy

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© 1995 Springer Science+Business Media New York

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Shibata, S., Kyuwa, S., Fujiwara, K., Toyoda, Y., Goto, N. (1995). Mouse Hepatitis Virus-Specific CD8+ Cytotoxic T Lymphocytes Induce Apoptosis in Their Target Cells. In: Talbot, P.J., Levy, G.A. (eds) Corona- and Related Viruses. Advances in Experimental Medicine and Biology, vol 380. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1899-0_17

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  • DOI: https://doi.org/10.1007/978-1-4615-1899-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5775-9

  • Online ISBN: 978-1-4615-1899-0

  • eBook Packages: Springer Book Archive

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