New Retinal Degenerations in the Mouse

  • Thomas H. Roderick
  • Bo Chang
  • Norman L. Hawes
  • John R. Heckenlively


For many years we followed with great interest the comparative advances of genetics in the mouse[l] and in human. [2] Relative frequencies of dominant and recessive traits were similar, mapping of genes proceeded at similar rates, and comparative mapping produced surprises through the discovery of the large number and size of mouse and human homologous chromosomal segments retained since the separation of the species 65 million years ago. What was different between mouse and human was the relative frequency of genetic eye disorders, that is, they were relatively frequent in human, and rare in mouse. Recognizing this was because of bias in ascertainment, because mice do not refer themselves for visual diagnosis and treatment, we began a systematic program to find and characterize mouse eye disorders. The Jackson Laboratory, having the largest collection of mouse mutant stocks and genetically diverse inbred strains was an ideal place to look for genetically determined eye variations and disorders. We have not been disappointed. Through ophthalmoscopy, electroretinography and histology, we have discovered disorders affecting all aspects of the eye including the lid, cornea, iris, lens, and retina, resulting in cornea disorders, cataracts, retinal degenerations and glaucoma. Additional studies have shown predisposition to certain eye problems in aged mice of specific stocks or strains.


Retinal Pigment Epithelium Outer Segment Photoreceptor Cell Retinal Degeneration Outer Nuclear Layer 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Thomas H. Roderick
    • 1
  • Bo Chang
    • 1
  • Norman L. Hawes
    • 1
  • John R. Heckenlively
    • 2
  1. 1.The Jackson LaboratoryUSA
  2. 2.The Jules Stein Eye InstituteLos AngelesUSA

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