In Vitro Expression of Epidermal Growth Factor Receptor by Human Retinal Pigment Epithelial Cells

  • Yusuf K. Durlu
  • Makoto Tamai


Growth factors regulate cell proliferation and differentiation (1). Epidermal growth factor (EGF) is a polypeptide mitogen that stimulates division of various cell types in vitro and, in particular, epithelial cells in vivo (1,2). It has been previously reported that the addition of EGF to culture medium increases DNA synthesis and number of cultured human retinal pigment epithelial (RPE) cells after 48 hr (3).


Epidermal Growth Factor Receptor Retinal Pigment Epithelial Retinal Pigment Epithelial Cell Proliferative Diabetic Retinopathy Proliferative Vitreoretinopathy 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Yusuf K. Durlu
    • 1
  • Makoto Tamai
    • 1
  1. 1.Department of OphthalmologyTohoku University, School of MedicineAoba-ku Sendai, MiyagiJapan

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