Skip to main content
SpringerLink
Log in

Ligand-Binding Properties of Recombinant Human IRBP

  • Chapter
Degenerative Diseases of the Retina

  • 128 Accesses

Abstract

Interphotoreceptor retinoid binding protein (IRBP) is a large glycolipoprotein synthesized by photoreceptor cells of the retina and secreted into interphotoreceptor matrix (IPM) (1). It binds and transports retinoids and fatty acids in the IPM as illustrated in Figure 1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bunt-Milam AH and Saari JC: Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. J Cell Biol. 1983;97:703–712.

    Article  CAS  PubMed  Google Scholar 

  2. Okajima T-IL., Pepperberg DR, Ripps H, Wiggert B and Chader GJ: Interphotoreceptor retinoid-binding protein: role in the delivery of retinol to the pigment epithelium. Exp Eye Res 1989;49:629–644.

    Article  CAS  PubMed  Google Scholar 

  3. Jones GJ, Crouch RK, Wiggert B, Cornwall MC and Chader GJ: Retinoid requirements for recovery of sensitivity after visual pigment bleaching in isolated photoreceptors. Proc Nat’l Acad Sci (USA) 1989;86:9606–9610.

    Article  CAS  Google Scholar 

  4. Okajima TI, Pepperberg DR, Ripps H, Wiggert B and Chader GJ: Interphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors. Proc Nat’l Acad Sci (USA) 1990;87:6907–6911.

    Article  CAS  Google Scholar 

  5. Crouch RK, Hazard ES, Lind T, Wiggert B, Chader G and Corson DW: Interphotoreceptor retinoid binding protein and alpha-tocopherol preserve the isomeric and oxidation state of retinol. Photochem Photobiol 1992;56:251–255.

    Article  CAS  PubMed  Google Scholar 

  6. Ho M-TP, Massey JB, Pownall HJ, Anderson RE and Hollyfield JG: Mechanism of vitamin A movement between rod outer segments, interphotoreceptor retinoid-binding protein, and liposomes. J Biol. Chem 1989;264:928–935.

    CAS  PubMed  Google Scholar 

  7. Lin ZY, Si JS and Nickerson JM: Biochemical and biophysical properties of recombinant human interphotoreceptor retinoid binding protein. Invest Ophthalmol. Vis Sci 1994;35:3599–3612.

    CAS  PubMed  Google Scholar 

  8. Si J-S, Borst DE, Redmond TM and Nickerson JM: Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences. Gene 1989;80:99–108.

    Article  CAS  PubMed  Google Scholar 

  9. Vialard J, Lalumiere M., Vernet T, Briedis D, Alkhatib G, Henning D, Levin D and Richardson C: Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the beta-galactosidase gene. Jour Virol 1990;64:37–50.

    CAS  Google Scholar 

  10. Cogan U, Kopelman M., Mokady S and Shinitzky M: Binding affinities of retinol and related compounds to retinol binding proteins. Eur J Biochem 1976;65:71–78.

    Article  CAS  PubMed  Google Scholar 

  11. Redmond TM, Wiggert B, Robey FA and Chader GJ: Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing [Erratum Biochem J 242 (1987) 935]. Biochem J 1986;240:19–26.

    CAS  PubMed Central  PubMed  Google Scholar 

  12. Putilina T, Sittenfeld D, Chader GJ and Wiggert B: Study of a fatty acid binding site of interphotoreceptor retinoid-binding protein using fluorescent fatty acids. Biochemistry 1993;32:3797–3803.

    Article  CAS  PubMed  Google Scholar 

  13. Adler AJ, Evans CD and Stafford WF, 3rd: Molecular properties of bovine interphotoreceptor retinol-bind-ing protein. J Biol. Chem 1985;260:4850–4855.

    CAS  PubMed  Google Scholar 

  14. Saari JC, Bunt-Milam AH, Bredberg DL and Garwin GG: Properties and immunocytochemical localization of three retinoid-bi proteins from bovine retina. Vision Res 1984;24:1595–1603.

    Article  CAS  PubMed  Google Scholar 

  15. Redmond TM and Nickerson JM: Retinoid binding to a recombinant central two repeat segment of IRBP. Invest Ophthalmol. Vis Sci 1992;33:1181.

    Google Scholar 

  16. Baer CA, Kittridge Kl., Klinger Al., Briercheck DM, Braiman MS and Gonzalez-Fernandez F: Expression and characterization of the fourth repeat of Xenopus interphotoreceptor retinoid binding protein in E. coli. Curr Eye Res 1994;13:391–400.

    Article  CAS  PubMed  Google Scholar 

  17. Chen Y, Saari J and Noy N: Interactions of all-trans-retinol and long chain fatty acids with interphotoreceptor retinoid binding protein. Biochemistry 1993;32:11311–11318.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ophthalmology Department, Emory University, Atlanta, Georgia, USA

    J. M. Nickerson, V. Mody, C. DeGuzman, K. A. Heron, K. Marciante, J. Boatright, J. S. Si & Z. Y. Lin

Authors
  1. J. M. Nickerson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Mody
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. DeGuzman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. A. Heron
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Marciante
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Boatright
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. S. Si
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Z. Y. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  2. University of California, San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  3. The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Joe G. Hollyfield

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Nickerson, J.M. et al. (1995). Ligand-Binding Properties of Recombinant Human IRBP. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Degenerative Diseases of the Retina. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1897-6_44

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1897-6_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5774-2

  • Online ISBN: 978-1-4615-1897-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation