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Scotopic Threshold Responses and Rod Intensity-Response Functions as Sensitive Indicators of the Carrier Status In X-Linked Recessive Retinitis Pigmentosa

  • A. Iannaccone
  • E. M. Vingolo
  • R. Forte
  • P. Tanzilli
  • B. Grammatico
  • C. De Bernardo
  • E. Rispoli
  • G. Del Porto
  • M. R. Pannarale
Chapter

Abstract

In previous studies several authors described modifications of ERG responses in X-linked recessive retinitis pigmentosa (xLRP) carriers (1–8). Investigations on the intensity-response functions of the rod ERG also demonstrated reduction of Vmax in subjects with ophthalmoscopic evidence of the carrier status (pigmentary changes and/or tapetal-like reflex) (4). In patients affected with RP abnormalities of the Oscillatory Potentials (OPs) have also been demonstrated (9,10), suggesting a coexisting impairment of the inner retinal layers. Abnormalities of rod sensitivity were also found at the psychophysical level to flickering stimuli (11).

Keywords

Retinitis Pigmentosa Amacrine Cell Central Retinal Vein Occlusion Inner Plexiform Layer Congenital Stationary Night Blindness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • A. Iannaccone
    • 1
  • E. M. Vingolo
    • 1
  • R. Forte
    • 1
  • P. Tanzilli
    • 1
  • B. Grammatico
    • 2
  • C. De Bernardo
    • 2
  • E. Rispoli
    • 1
  • G. Del Porto
    • 2
  • M. R. Pannarale
    • 1
  1. 1.Department of Ocular Electrophysiology, Center for Inherited Degenerative Retinal DisordersUniversity “La Sapienza”, Institute of OphthalmologyRomeItaly
  2. 2.Medical Genetic Section of the Experimental Medicine DepartmentUniversity “La Sapienza”RomeItaly

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