Inhibitory Effects of Cycloheximide and Flunarizine on Light-Induced Apoptosis of Photoreceptor Cells

  • Suhui Li
  • Cheng-Jong Chang
  • Andrew S. Abler
  • Mark O. M. Tso


The pathogenesis of photic retinopathy has been actively investigated for many years. Although the exact pathogenic mechanism involved in light-induced photoreceptor degeneration remains unknown, certain hypotheses were made based on previous animal studies [1-8]. Free radical formation and lipid peroxidation are among the most widely accepted hypotheses regarding the pathogenesis of photic retinopathy [1-5]. In addition, possible roles for protein synthesis and alteration of intracellular Ca2+ concentration in light-induced photoreceptor cell death have been suggested [6–8]. Protein synthesis inhibitors, such as cycloheximide and Ca2+ channel overload blockers, such as flunarizine, were both demonstrated to have ameliorative effects on retinal photic injury [6–8]. These findings provided supportive evidence of the possible involvement of protein synthesis and alteration of intracellular Ca2+ concentration in retinal photic injury. However, the mechanism whereby these two factors ameliorated light-induced photoreceptor cell death was not determined.


Retinal Pigment Epithelium Intravitreal Injection Outer Segment Photoreceptor Cell Outer Nuclear Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Suhui Li
    • 1
  • Cheng-Jong Chang
    • 1
  • Andrew S. Abler
    • 1
  • Mark O. M. Tso
    • 1
  1. 1.Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory Department of Ophthalmology and Visual SciencesUniversity of Illinois at ChicagoChicagoUSA

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