Inhibitory Effects of Cycloheximide and Flunarizine on Light-Induced Apoptosis of Photoreceptor Cells

  • Suhui Li
  • Cheng-Jong Chang
  • Andrew S. Abler
  • Mark O. M. Tso

Abstract

The pathogenesis of photic retinopathy has been actively investigated for many years. Although the exact pathogenic mechanism involved in light-induced photoreceptor degeneration remains unknown, certain hypotheses were made based on previous animal studies [1-8]. Free radical formation and lipid peroxidation are among the most widely accepted hypotheses regarding the pathogenesis of photic retinopathy [1-5]. In addition, possible roles for protein synthesis and alteration of intracellular Ca2+ concentration in light-induced photoreceptor cell death have been suggested [6–8]. Protein synthesis inhibitors, such as cycloheximide and Ca2+ channel overload blockers, such as flunarizine, were both demonstrated to have ameliorative effects on retinal photic injury [6–8]. These findings provided supportive evidence of the possible involvement of protein synthesis and alteration of intracellular Ca2+ concentration in retinal photic injury. However, the mechanism whereby these two factors ameliorated light-induced photoreceptor cell death was not determined.

Keywords

DMSO Cobalt Adenocarcinoma Sodium Chloride Epoxy 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Suhui Li
    • 1
  • Cheng-Jong Chang
    • 1
  • Andrew S. Abler
    • 1
  • Mark O. M. Tso
    • 1
  1. 1.Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory Department of Ophthalmology and Visual SciencesUniversity of Illinois at ChicagoChicagoUSA

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