Guanylate Cyclase-Activating Protein (GCAP)

A Novel Ca2+-Binding Protein in Vertebrate Photoreceptors
  • Wolfgang Baehr
  • Iswari Subbaraya
  • Wojciech A. Gorczyca
  • Krzysztof Palczewski


Vertebrate photoreceptors respond to light by a transient hyperpolarization of the plasma membrane. Hyperpolarization is achieved when cGMP-gated cation channels, located in the plasma membrane, are closed after hydrolysis of the gating ligand, cGMP ( 1,28). To re-open the channels, a prerequisite to return photoreceptors to the dark-adapted state, cGMP has to be produced at an accelerated rate by a guanylate cyclase (GC). As shown by numerous electrophysiological and biochemical experiments, activation of GC is regulated bv Ca2+ ions.


Guanylate Cyclase Membrane Guanylate Cyclase Congenital Stationary Night Blindness cGMP Phosphodiesterase Guanylate Cyclase Stimulation 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Wolfgang Baehr
    • 1
  • Iswari Subbaraya
    • 1
  • Wojciech A. Gorczyca
    • 2
  • Krzysztof Palczewski
    • 2
  1. 1.Department of OphthalmologyBaylor College of MedicineHoustonUSA
  2. 2.Departments of Ophthalmology and PharmacologyUniversity of WashingtonSeattleUSA

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