Abstract
Vertebrate photoreceptors respond to light by a transient hyperpolarization of the plasma membrane. Hyperpolarization is achieved when cGMP-gated cation channels, located in the plasma membrane, are closed after hydrolysis of the gating ligand, cGMP ( 1,28). To re-open the channels, a prerequisite to return photoreceptors to the dark-adapted state, cGMP has to be produced at an accelerated rate by a guanylate cyclase (GC). As shown by numerous electrophysiological and biochemical experiments, activation of GC is regulated bv Ca2+ ions.
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Baehr, W., Subbaraya, I., Gorczyca, W.A., Palczewski, K. (1995). Guanylate Cyclase-Activating Protein (GCAP). In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Degenerative Diseases of the Retina. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1897-6_38
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DOI: https://doi.org/10.1007/978-1-4615-1897-6_38
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