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Guanylate Cyclase-Activating Protein (GCAP)

A Novel Ca2+-Binding Protein in Vertebrate Photoreceptors
  • Wolfgang Baehr
  • Iswari Subbaraya
  • Wojciech A. Gorczyca
  • Krzysztof Palczewski

Abstract

Vertebrate photoreceptors respond to light by a transient hyperpolarization of the plasma membrane. Hyperpolarization is achieved when cGMP-gated cation channels, located in the plasma membrane, are closed after hydrolysis of the gating ligand, cGMP ( 1,28). To re-open the channels, a prerequisite to return photoreceptors to the dark-adapted state, cGMP has to be produced at an accelerated rate by a guanylate cyclase (GC). As shown by numerous electrophysiological and biochemical experiments, activation of GC is regulated bv Ca2+ ions.

Keywords

Guanylate Cyclase Membrane Guanylate Cyclase Congenital Stationary Night Blindness cGMP Phosphodiesterase Guanylate Cyclase Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Wolfgang Baehr
    • 1
  • Iswari Subbaraya
    • 1
  • Wojciech A. Gorczyca
    • 2
  • Krzysztof Palczewski
    • 2
  1. 1.Department of OphthalmologyBaylor College of MedicineHoustonUSA
  2. 2.Departments of Ophthalmology and PharmacologyUniversity of WashingtonSeattleUSA

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