Retinal Pathology in Retinitis Pigmentosa

Considerations for Therapy
  • Ann H. Milam
  • Zong-Yi Li


Retinitis pigmentosa (RP) causes primary degeneration of photoreceptors, followed by reactive changes in the retinal pigment epithelium (RPE) and Müller glia, death of inner retinal neurons, and atrophy of the retinal vasculature. Current strategies for retinal therapy include transplantation of normal photoreceptors, delivery of corrective genes to diseased photoreceptors, and electrical stimulation of inner retinal neurons [1–5]. This chapter will review the histopathology of the retina in RP, including the characteristic changes found in the photoreceptors, subretinal space, RPE and choriocapillaris, Müller glia, inner retinal neurons and blood vessels. Changes in these retinal components secondary to death of photoreceptors are important considerations in developing new therapies for RP


Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Retinitis Pigmentosa Outer Segment Retinal Neuron 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Ann H. Milam
    • 1
  • Zong-Yi Li
    • 1
  1. 1.Department of Ophthalmology RJ-10University of WashingtonSeattleUSA

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