Iron and Hereditary Degeneration of the Retina

  • R. N. Etingof
  • N. D. Shushakova
  • M. G. Yefimova


Because of its involvement in haem and nonhaem iron containing enzymes iron is required by all cells of organism. The particular role of this ion was shown for the nervous tissue and especially for brain (Connor et al., 1990). It is known, that iron status of organism has an influence on the iron level in brain. The iron status is estimated by the content of nonhaem iron (NHI) in the complex with transferrin (TF) in blood plasma and by the quantity of NHI in hepatic cells ferritin (F) (Taylor et al, 1991;). The decreased iron status of the organism (in contrast to the increased one) causes the most significant effects: a decrease of NHI content in brain and different biochemical and functional abnormalities in the latter (Youdim et al, 1989; Oloyede et al., 1992). Recent studies have accumulated interesting data showing that disturbances of brain iron homeostasis have a crucial role in the development of some neurodegen-erative diseases, such as Alzheimer’s, Parkinson’s, Wilson’s diseases etc. (Connor et al., 1992; Youdim & Riederer,1993; Hafkemeyer et al., 1994; Saija et al., 1994).


Retinal Pigment Epithelium Blood Plasma Retinal Pigment Epithelium Cell Iron Status Brain Cortex 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • R. N. Etingof
    • 1
  • N. D. Shushakova
    • 1
  • M. G. Yefimova
    • 1
  1. 1.I.M.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgRussia

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