Oxidative Damage and Responses in Retinal Nuclei Arising from Intense Light Exposure
Prolonged or high intensity visible light exposure leads to photoreceptor cell damage and loss by incompletely understood mechanisms. In the rat retina, the sequence of events associated with intense light damage is triggered by the bleaching of rhodopsin (1), and the extent of damage is modulated by other photoreceptor cell proteins involved in visual transduction (2). Thus, environmental light-rearing conditions that alter the steady state levels of rhodopsin, α-transducin and s-antigen (arrestin) can affect the ultimate fate of visual cells (2,3). However, irrespective of their prior light-rearing environment, when rats are pretreated with natural or synthetic antioxidants, retinal light damage is less than in unsupplemented animals (4–8). This indicates that intense light exposure also results in oxidative reactions within the photoreceptor cell.
KeywordsLight Exposure Light Treatment Photoreceptor Cell Opsin Gene Visual Cell
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- 3.Penn JS, Thum LA. A comparison of the retinal effects of light damage and high illuminance light history. In: Hollyfield JG, Anderson RE, LaVail MM, eds. Degenerative Retinal Disorders: Clinical and Laboratory Investigations. New York: Alan R Liss; 1987: 425–438.Google Scholar
- 9.Kuwabara T, Funahashi M. Light effect on the synaptic organ of the rat. Invest. Ophthalmol. Vis. Sci. 1976; 15: 407–411.Google Scholar
- 11.Messing SL, Darrow R, Leffak M., Fleischman D, Organisciak DT. Visible light-induced damage to retinal DNA in vivo. Invest. Ophthalmol. Vis. Sci. 1994; 35: 2138.Google Scholar
- 13.Wong P, Kutty RK, Darrow RM, Shivaram S, Kutty G, Fletcher RT, Wiggert B, Chader G, Organisciak DT. Changes in TRPM-2/Clusterin expression associated with light induced retinal damage in rats. Biochem Cell Biology (in press).Google Scholar
- 16.Maniatis T, Fritsch EF, and Sambrook J. (1982). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory).Google Scholar