Activation of Protein Kinase C Mediates Insulin Regulation of the Na-K Pump in Cultured Skeletal Muscle

  • S. R. Sampson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 381)


At first glance, the inclusion of this lecture in this symposium might seem to be a bit superfluous -what possible connection is there between regulation of Na+ -K+ pump activity in skeletal muscle and control of the respiratory and cardiovascular systems? A brief reflection will, of course, provide the answer. Skeletal muscle represents approximately 40% of the body weight and is a major source of K+. Indeed, during muscle exercise muscle activity can lead to a doubling of [K+]o, and a responsive and active Na+ -K+ pump is absolutely essential for continued muscle and cardiovascular function. In addition, the pump plays an important role in control of cardiac and smooth muscle function. Hence, knowledge of the regulatory and signaling mechanisms involved in Na+ -K+ pump activity may also provide information regarding important regulatory mechanisms of respiratory and cardiovascular activity.


Skeletal Muscle Phorbol Ester Pump Activity Ouabain Binding Chick Skeletal Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • S. R. Sampson
    • 1
  1. 1.Health Sciences Research Center and The Otto Meyerhoff Center for the Study of Drug-Receptor Interactions, Department of Life SciencesBar-Ilan UniversityRamat-GanIsrael

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