Graded Restriction of Blood Flow in Exercising Leg Muscles

A Human Model
  • Hilding Bjurstedt
  • Ola Eiken
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 381)


Much of our knowledge about the effects of acute muscle ischemia on the respiration and central circulation in humans has been derived from studies in which the circulation in muscles has been completely arrested by the use of inflatable cuffs. Notable examples are the classical experiments by Alam & Smirk in the 30s (1937). They blocked the circulation of one forearm and found that the trapping of metabolites within the limb after exercise prevented the postexercise fall in arterial pressure. Later, Asmussen & Nielsen (1964) also used the cuff method during dynamic leg exercise, and presented evidence that both the pressor response and the hyperpnea of exercise may in part originate from stimulation of muscle afferents sensitive to local metabolic changes in ischemic muscle. Yet, complete blocking of the circulation to an exercising limb can only be maintained for short periods and may give rise to pain and other adverse effects with physiological consequences of mixed origin. There has been a need for a method by which the experimenter can induce partial restriction of blood flow in large muscle groups, and control both the degree and the duration of the restriction within wide limits.


Blood Lactate Endurance Training Intermittent Claudication Dynamic Exercise Muscle Blood Flow 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Hilding Bjurstedt
    • 1
    • 3
  • Ola Eiken
    • 2
  1. 1.Environmental Physiology Laboratory, Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden
  2. 2.Department of Clinical PhysiologyKarolinska Institute, Huddinge HospitalHuddingeSweden
  3. 3.Environmental Physiology Laboratory, Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden

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