Graded Restriction of Blood Flow in Exercising Leg Muscles
Much of our knowledge about the effects of acute muscle ischemia on the respiration and central circulation in humans has been derived from studies in which the circulation in muscles has been completely arrested by the use of inflatable cuffs. Notable examples are the classical experiments by Alam & Smirk in the 30s (1937). They blocked the circulation of one forearm and found that the trapping of metabolites within the limb after exercise prevented the postexercise fall in arterial pressure. Later, Asmussen & Nielsen (1964) also used the cuff method during dynamic leg exercise, and presented evidence that both the pressor response and the hyperpnea of exercise may in part originate from stimulation of muscle afferents sensitive to local metabolic changes in ischemic muscle. Yet, complete blocking of the circulation to an exercising limb can only be maintained for short periods and may give rise to pain and other adverse effects with physiological consequences of mixed origin. There has been a need for a method by which the experimenter can induce partial restriction of blood flow in large muscle groups, and control both the degree and the duration of the restriction within wide limits.
KeywordsFatigue Ischemia Lactate Citrate Rubber
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