Model Studies of Cellular Excitation

  • Yoram Rudy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 382)

Abstract

A mathematical model of the cardiac ventricular cell is used to describe ionic currents and dynamic concentration changes during a normal action potential. The model is also used to study arrhythmogenic activity of the single cell including early afterdepolarizations, delayed afterdepolarizations and rhythmic (spontaneous and triggered) activity under various degrees of calcium overload.

Keywords

Ischemia Catecholamine Rosen Ileal Cali 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Luo CH, Rudy Y: A model of the ventricular cardiac action potential, depolarization, repolarization, and their interaction. Circ Res. 1991; 68: 1501–1526.PubMedCrossRefGoogle Scholar
  2. 2.
    Luo CH and Rudy Y: A dynamic model of the cardiac ventricular action potential I: Simulations of ionic currents and concentration changes. Circ Res. 1994; 74: 1701–1096.Google Scholar
  3. 3.
    Luo CH and Rudy Y: A dynamic model of the cardiac ventricular action potential II: Afterdepolarizations, triggered activity, and potenitation. Circ Res. 1994; 74: 1097–1113.PubMedCrossRefGoogle Scholar
  4. 4.
    Beeler GW, Reuter H: Reconstruction of the action potential of ventricular myocardial fibres. J Physiol (Lond). 1977; 268: 177–210.Google Scholar
  5. 5.
    Cranefield PF, Aronson RS: Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms. Futura Publishing Company, Inc., New York, USA, 1988.Google Scholar
  6. 6.
    Rosen MR: The concept of afterdepolarization. In: Cardiac Electrophysiology: A Textbook (Rosen MR, Janse MJ, and Wit AL, editors). Futura Publishing Co., New York. 1990; Chapter 3: 267–282.Google Scholar
  7. 7.
    Zeng J, Rudy Y.: Simulation studies of the mechanism of arrhythmogenic early afterdepolarizations in cardiac myocytes. 38th Annual Meeting of The Biophysical Society. Biophys J. 1994;66:A322.Google Scholar
  8. 8.
    Zeng J, Rudy Y: Simulation studies of the rate dependence mechanism of early and delayed afterdepolarizations. FASEB J. 1994;6:A77.Google Scholar
  9. 9.
    Zeng J, Rudy Y. Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence. Biophys J. 1995; in press.Google Scholar
  10. 10.
    Isenberg G, Klockner U: Calcium current of isolated bovine ventricular myocytes are fast and of large amplitude. Pflugers Archiv. 1982; 395: 30–41.PubMedCrossRefGoogle Scholar
  11. 11.
    Campbell DL, Giles WR, Robinson K, Shibata EF: Studies of the sodium-calcium exchanger in bull-frog atrial myocytes. J Physiol (Lond). 1988; 403: 317–340.Google Scholar
  12. 12.
    Doerr T, Denger R, Doerr A, Trautwein W: Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflugers Archiv. 1990; 416: 230–237.PubMedCrossRefGoogle Scholar
  13. 13.
    Priori SG, Corr PB: Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. Am J Physiol. 1990; 258: H1796–H1805.PubMedGoogle Scholar
  14. 14.
    Stern MD, Capogrossi MC, Lakatta EG: Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences. Cell Calcium. 1988; 9: 247–256.PubMedCrossRefGoogle Scholar
  15. 15.
    Marban E, Robinson SW, Wier WG: Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J Clin Invest. 1986; 78: 1185–1192.PubMedCrossRefGoogle Scholar
  16. 16.
    January CT, Riddle JM: Early afterdepolarizations: mechanism of induction and block, a role for L-type Ca2+ current. Circ Res.1989; 48: 720–727.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Yoram Rudy
    • 1
  1. 1.The Cardiac Bioelectricity Research and Training Center, Department of Biomedical EngineeringCase Western Reserve UniversityClevelandUSA

Personalised recommendations