Abstract
Quantification of myocardial strains is essential for understanding cardiac mechanics. Previous techniques for assessing regional myocardial strains have been mainly limited to invasive procedures. A technique by which tagging can be added to magnetic resonance images (MRI) has recently been introduced and allows for noninvasive measurement of myocardial deformations. We have applied MRI tagging to two sets of orthogonal planes and have obtained three dimensional (3D) reconstructions of 24 myocardial cuboids at end-diastole (ED) and at end-systole (ES). Applying finite strain analysis to these cuboids we were able to study the longitudinal distribution of the endocardial and epicardial principal strains (PS) in the normal canine heart. In addition we have calculated the longitudinal distribution of the left ventricular (LV) transmural thickening using a 3D approach. Our results show similarity in the longitudinal distribution of endocardial PS and transmural thickening. These results imply that endocardial s rains are determined not only by endocardial fiber deformations but mainly by geometrical coupling through transmural thickening.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Prinzen FW, Arts T, Van Der Vus GJ, Reneman RS. Fiber shortening in the inner layers of the ventricular wall as assessed from epicardial deformation during normoxia and ischemia. J Biomech. 1984;17:801–811.
Dieudonne JM. Gradients de directions et la deformations principales dans la paroi ventriculaire gauch normale. J Physiol (Paris). 1969;61:305–330.
Hawthorne EW. Dynamic geometry of the left ventricle. Am J Cardiol 1966;18:566–573.
Waldman LK, Fung YC, Covell JW. Transmural myocardial deformation in the canine left ventricle. Normal in vivo three-dimensional finite strains. Circ Res. 1985;57:152–163.
Yun KL, Niczyporuk MA, Daughters GT, Ingels NB, Stinson EB, Alderman EL, Hansen DE, Miller DC. Alterations in left ventricular diastolic twist mechanics during acute human cardiac allograft rejection. Circulation. 1991;83:962–973.
Freeman GL, LeWinter MM, Engler RL, Covell JW. Relationship between myocardial fiber direction and segment shortening in the midwall of the canine left ventricle. Circ Res. 1985;56:31–39.
Villarreal FJ, Lew WY. Finite strain in the anterior and posterior wall of canine left ventricle. Am J Physiol. (Heart Circ Physiol. 28): 1990;259:H1409–1418.
Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol. (Heart Circ Physiol.) 1990;259:H300–308.
Lab MJ, Woollard KV. Monophasic action potential, electrocardiograms and mechanical performance in normal and ischemic epicardial segments of the pig ventricle in situ. Cardiovascular Res. 1978;12:555–565.
Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EP. Human heart: Tagging with MR imaging-A method for noninvasive assessment of myocardial motion. Radiology. 1988;169:59–63.
Axel L, Dougherty L. MR imaging of motion with spatial modulation of magnetization. Radiology. 1989;171:841–845.
Azhari, H., J. L. Weiss, W. J. Rogers, C. O. Siu, E. A. Zerhouni, E. P. Shapiro. Non-invasive quantification of principal strains in normal canine hearts using tagged MRI images in 3D. Am. J. Physiol 264: (Heart Circ. Physiol. 33): H205-H216, 1993.
Azhari H, Weiss JL, Rogers WJ, Siu C, Shapiro EP. A Non-invasive comparative study of myocardial strains in ischemic canine hearts using tagged MRI in 3D. Am J Physiol. 1994;in press.
Beyar R, Shapiro EP, Graves WL, Rogers WJ, Guier WH, Carey GA, Soulen RL, Zerhouni EA, Weisfeldt ML, Weiss JL. Quantification and validation of left ventricular wall thickening by a three dimensional volume element magnetic resonance imaging approach. Circulation. 1990;81:297–307.
MacGowan GA, Azhari H, Rademakers FE, Rogers WJ, Perry LV, Hutchins GM, Weiss JL, Shapiro EP. Quantification of principal strains in the normal human left ventricles using tagged magnetic resonance imaging in 3D. 65th Scientific Sessions of the American Heart Association, New Orleans, LA, Nov. 16–19. Circulation. 1992;86(4)(Supp. I): 166.
Azhari H, Oliker S, Rogers WJ, Weiss JL, Shapiro EP. Three dimensional mapping of acute ischemic regions using Artificial neural networks and Tagged MRI. IEEE Trans on Biomed. Eng. 1995; in press.
Iwasaki T, Sinak LJ, Hoffman EA, Robb RA, Harris LD, Bahn RC, Ritman EL. Mass of left ventricular myocardium estimated with dynamic spatial reconstructor. Am J Physiol 246 (Heart Circ Physiol.) 1984;15:H138-H142.
Shapiro EP, Rogers WJ, Beyar R, Soulen RL, Zerhouni EA, Lima JAC, Weiss JL. Determination of left ventricular mass by magnetic resonance imaging in hearts deformed by acute infarction. Circulation. 1989;79:706–711.
MacGowan GA, Shapiro EP, Salvado RD, Azhari H, Rogers WJ, Guier WH, Hutchins G, Lima JAC, Weiss JL, Rademakers FE. Cross-fiber shortening is preserved in human idiopathic dilated cardiomyopathy (abstract). Circulation. 1993;88(4):I–346.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Azhari, H., Weiss, J.L., Shapiro, E.P. (1995). Distribution of Myocardial Strains: An MRI Study. In: Sideman, S., Beyar, R. (eds) Molecular and Subcellular Cardiology. Advances in Experimental Medicine and Biology, vol 382. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1893-8_31
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1893-8_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5772-8
Online ISBN: 978-1-4615-1893-8
eBook Packages: Springer Book Archive