Integration of Structure, Function and Mass Transport in the Myocardium

  • Daniel Zinemanas
  • Rafael Beyar
  • Samuel Sideman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 382)


A left ventricular (LV) model that integrates muscle mechanics, coronary flow, and fluid transport, and accounts for the three-phase (fiber-blood-interstitium) myocardial structure and composition, is used to study the interactions between the mechanics, coronary flow and fluid and mass transport in the myocardium. Theoretical simulations elucidate the effects of ventricular load, coronary perfusion pressure, and fluid and mass transport on ventricular performance and coronary dynamics. The analysis yields a direct relation between cardiac function and structure to cardiac mechanics, coronary flow, and intramyocardial fluid (and mass) transport, and allows to study the interactions between coronary flow, ventricular and myocardial mechanics and intramyocardial fluid shifts.


Coronary Flow Interstitial Fluid Coronary Blood Flow Aortic Pressure Left Ventricular Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Daniel Zinemanas
  • Rafael Beyar
  • Samuel Sideman
    • 1
  1. 1.Heart System Research Center, The Julius Silver Institute, Department of Biomedical EngineeringTechnion-IITHaifaIsrael

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