Altered Gene Transcription Following Brief Episodes of Coronary Occlusions

  • Ralph Knöll
  • René Zimmermann
  • Wolfgang Schaper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 382)


This study was designed to elucidate whether previously observed enhanced mRNAs were due to accelerated transcription, enhanced mRNA stability or both mechanisms. We employed the nuclear run-on technique on myocardial nuclei and found the transcriptional induction of several genes, especially nuclear protooncogenes, Ca2+ regulating and heat shock protein genes.


Left Anterior Descend Coronary Occlusion Transcriptional Induction Heat Shock Protein Gene Myocyte Nucleus 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Ralph Knöll
  • René Zimmermann
  • Wolfgang Schaper
    • 1
  1. 1.Department of Experimental CardiologyMax-Planck-InstituteBad NauheimF.R. Germany

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