Abstract
The study deals with the description of muscle contraction based on biochemical studies and describes four major approaches for coupling calcium kinetics with crossbridge (Xb) cycling. The analysis illuminates two controversial points: 1) the relationship between Xb attachment/detachment and Xb cycling, i.e., the transition between weak to strong conformations, and 2) the effect of calcium on Xb function: does it regulate Xb kinetics or Xb recruitment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Huxley AF. Muscle contraction. J Physiol. 1974;243:1–43.
Eisenberg E, Hill TL. Muscle contraction and free energy transduction in biological system. Science. 1985;227:999–1006.
Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE. The Heart and Cardiovascular System, Scientific Foundations. Second edition. NY: Raven Press. 1991:1281–1295.
Brenner B. Rapid dissociation and reassociation of actomyosin crossbridge during force generation: a newly observed facet of crossbridges action in muscle. Proc Natl Acad Sci. 1991;88:10490–10494.
Wong ALK. Mechanics of cardiac muscle, based on huxley’s model: mathematical simulation of isometric contraction. J Biomechanics. 1971;4:529–540.
Brenner B. Effect of Ca2+ on crossbridge turnover kinetics in skinned single rabbit psoas fibers: implication for regulation of muscle contraction. Proc Nat Acad Sci. 1988;85:3265–3269.
Zahalak IG, Shi-ping MA. Muscle activation and contraction: constitutive relations based directly on crossbridge kinetics. J Biomechan Eng. 1990;112:52–62.
Landesberg A, Sideman S. Coupling calcium binding to Troponin-C and cross-bridge cycling kinetics in skinned cardiac cells. Am J Physiology 1994;266(Heart Circ Physiol 35): H1260–H1271.
Landesberg A, Sideman S. Mechanical regulation in the cardiac muscle by coupling calcium binding to troponin-C and crossbridge cycling. A dynamic model. Am J Physiol 1994;267(Heart Circ Physiol 36):H779–H795.
Gao WD, ter Keurs HEDJ, Typberg JV, Zeverson D, Macintosh RB, Suga H. Energy erivation and cardiac mechanics. Ph.D. Thesis, University of Calgary, Dept. of Medical Science, December, 1991.
Peterson JN, Hunter WC, Berman MR. Estimated time course of calcium bound to troponin-c during relaxation in isolated cardiac muscle. Am J Physiol. 1991;260:H1013–H1024.
Robertson SP, Johnson P, Potter JD. The time course of calcium exchange with calmodulin, troponin, paralbumin and myosin in response to transient increase in calcium. Biophys J. 1981;34:559–569.
Lombardi V, Puazzesi G, Linari M. Rapid regeneration of actin-myosin power stroke in contracting muscle. Nature. 1992;355:638–641.
Chalovich J, Chock MPB, Eisenberg E. Mechanism of action of troponin-tropomyosin. J Biol Chem. 1981;256:557–578.
Chalovich JM, Eisenberg E. The effect of troponin -tropomyosin on the binding of heavy meromyosin to actin in the presence of ATP. J Biol Chem. 1986;261:5088–5093.
Grabarek Z, Grabarek J, Leavis PJ, Gergely J. Cooperative binding to Ca -specific sites of troponin C in regulated actin and actomyosin. J Biol Chem. 1983;258:14098–14102.
Landesberg A, Sideman S. Calcium kinetic and mechanical regulation of the cardiac muscle. In: Sideman S, Beyar R (eds) Interactive Phenomena in the Cardiac System, Proc of the 8th Henry Goldberg Workshop, Bethesda, MD, 1992. NY:Plenum Publishing Corp, 1993:59–77.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Landesberg, A., Beyar, R., Sideman, S. (1995). Crossbridge Dynamics in Muscle Contraction. In: Sideman, S., Beyar, R. (eds) Molecular and Subcellular Cardiology. Advances in Experimental Medicine and Biology, vol 382. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1893-8_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1893-8_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5772-8
Online ISBN: 978-1-4615-1893-8
eBook Packages: Springer Book Archive