Skip to main content

Experimental Feline Lyme Borreliosis as a Model for Testing Borrelia Burgdorferi Vaccines

  • Chapter
Immunobiology of Proteins and Peptides VIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 383))

Abstract

Lyme disease is a multisymptom disease resulting in dermatologic, rheumatologic, neurologic and cardiac abnormalities which develop in stages with various clinical pictures (1) following infection by a newly discovered spirochete, Borrelia burgdorferi (2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Steere, A.C. 1989. Lyme disease. N Engl J Med. 321:586–596.

    Article  PubMed  CAS  Google Scholar 

  2. Steere, A.C., Grodzicki, R.L., and Kornblatt, A.N. 1983. The spirochetal etiology of Lyme disease. N Engl J Med. 308:733.

    Article  PubMed  CAS  Google Scholar 

  3. Schmid, G.P. 1985. The global distribution of Lyme disease. Rev Infect Dis 7:41–50.

    Article  PubMed  CAS  Google Scholar 

  4. Dekonenko, E.J., Steere, A.C., and Berardi, V.P. 1988. Lyme borreliosis in the Soviet Union: a cooperative US-USSR report. J Infect Dis. 748–753.

    Google Scholar 

  5. Ai, C.X., Wen, Y.X., and Zhang, Y.G. 1988. Clinical manifestations and epidemiological characteristics of Lyme disease in Bailin county, Heilongjiang Province, China. Ann NY Acad Sci. 539:302–313.

    Article  PubMed  CAS  Google Scholar 

  6. Isogai, E., Isogai, H., and Sato, N. 1990. Antibodies to Borrelia burgdorferi in dogs in Hokkaido. Microbiol Immunol. 34:1005–1012.

    PubMed  CAS  Google Scholar 

  7. Fivaz, B.H. and Petney, T.N. 1989. Lyme disease-a new disease in southern Africa? J S Afr Vet Assoc. 60:155–158.

    PubMed  CAS  Google Scholar 

  8. Haberberger, R.L. Jr., Constantine, N.T., Shwan, T.G. et al. 1989. Lyme disease agent in Egypt. Trans R Soc Trop Med 83:556.

    Article  Google Scholar 

  9. Schmid, G.P. 1989. Epidemiology and clinical similarities of human spirochetal diseases. Rev Infect Dis. Supp 6:S1460–S1469.

    Article  Google Scholar 

  10. Barbour, A.G. and Hayes, S.F. 1986. Biology of Borrelia species. Microbiol Rev. 50:381–400.

    PubMed  CAS  Google Scholar 

  11. Burgdorfer, W. 1984. Discovery of the Lyme disease spirochete and its relation to tick vectors. Yale J. Biol. Med. 57:515–520.

    CAS  Google Scholar 

  12. Duray, P.H., Kusnitz, A. and Rayan, J. 1985. Demonstration of the Lyme disease spirochete by modified Dieterle stain methods. Lab. Med. 16:685–687.

    Google Scholar 

  13. de Koning, J., Bosma, A.B. and Hoogkamp-Korstanje, A.A. 1987. Demonstration of spirochetes in patients with Lyme disease in a modified silver stain. J. Med. Microbiol. 23:261–267.

    Article  PubMed  Google Scholar 

  14. Swisher, B.L. Modified Steiner procedure for microwave staining of spirochaetes and nonfilamentous bacteria. J. Histotech. 10:241–243.

    Google Scholar 

  15. Burgdorfer, W. 1989. Vector/host relationships of the Lyme disease spirochete Borrelia burgdorferi. Rheum. Dis. Clin. North Am. 15:748–753.

    Google Scholar 

  16. Anderson, J.F. 1989. Vector/host relationships of the Lyme disease spirochete Borrelia burgdorferi. Rheum. Dis. Clin. North Am. 15:748–753.

    Google Scholar 

  17. Bosler, E.M. 1992. Tick Vectors and Hosts. In: Lyme Disease. P.K. Coyle, ed. Mosby Year Book, St. Louis, p. 18–26.

    Google Scholar 

  18. Magnarelli, L.A. and Anderson, J.F. 1988. Ticks and biting insects infected with the etiologic agent of Lyme disease, Borrelia burgdorferi. J. Clin. Microb. 26:1482–1486.

    CAS  Google Scholar 

  19. Schulze, T.L., Bowen, G.S., and Bosler, E.M. 1984. Amblyomma americanum: A potential vector of Lyme disease in New Jersey. Science. 224:601–603.

    Article  PubMed  CAS  Google Scholar 

  20. Piesman, J. and Stinsky, R.J. 1988. Ability of Rodes pacificus,Dermacentor variabilis and Amblyomma americanum (Acri: Ixodidae) to acquire, maintain and transmit Lyme disease spirochetes, Borrelia burgdorferi. J. Med. Entomol. 25:336.

    CAS  Google Scholar 

  21. Rousselle, C., Floret, D., Cochat, P., et al. 1989. Encephalite aigue a Borrelia burgdorferi (maladie de Lyme) ches un enfant algerien. Pediatrie 44:265–269.

    PubMed  CAS  Google Scholar 

  22. Kawabata, M. 1987. Lyme disease in Japan and its possible incriminated tick vector, Ixodes persukatus. J. Infect. Dis. 156:854.

    Article  PubMed  CAS  Google Scholar 

  23. Post, J.E. 1990. Lyme disease in large animals. NJ Med. 87:575–577.

    CAS  Google Scholar 

  24. Tetlow, G.J., Fournier, P.V. and Rawlings, J.A. 1991. Isolation of Borrelia burgdorferi from arthropods collected in Texas. Am. J. Trop. Med. Hyg. 44:469–474.

    Google Scholar 

  25. .Cohen, D., Bosler, E.M., Bernard, W., et al. 1988. Epidemiologic studies of Lyme disease in horses and their public health significance. Ann. NYAcad. Sci. 539:244–257.

    Article  Google Scholar 

  26. Weisbrod, A.R. and Johnson, R.C. 1989. Lyme disease and migrating birds in Staint Croix River Valley. Appl. Environ. Microbiol. 55:1921–1924.

    CAS  Google Scholar 

  27. Burgess, E.C., Gendron-Fitzpatrick, A. and Wright, W.O. 1987. Arthritis and systemic disease caused by Borrelia burgdorferi infection in a cow. J.A.V.M.A. 191:1468–1470.

    CAS  Google Scholar 

  28. Burgess, E.C. and Mattison, M. 1987. Encephalitis associated with Borrelia burgdorferi infection in a horse. J.A.VM.A. 191:1457–1458.

    CAS  Google Scholar 

  29. Burgess, E.C. 1988. Borrelia burgdorferi infection in horses and cows. Ann. NYAcad. Sci. 539:234–243.

    Article  Google Scholar 

  30. Bosler, E.M., Cohen, D.P., and Schulze, T.L. 1988. Host responses to Borrelia burgdorferi in dogs and horses. Ann. NYAcad. Sci. 539:244–257.

    Article  Google Scholar 

  31. Post, J.E., Shaw, E.E. and Wright, S.D. 1988. Suspected borreliosis in cattle. Ann. NYAcad. Sci. 539:488.

    Article  Google Scholar 

  32. Magnarelli, L.A., Anderson, J.E. and Chappell, W.A. 1984. Geographic distribution of humans, raccoons, and white-footed mice with antibodies to Lyme disease spirochetes in Connecticut. Yale J. Biol. Med. 57:619–626.

    PubMed  CAS  Google Scholar 

  33. Burgdorfer, W. 1984. The New Zealand white rabbit: An experimental host for infecting ticks with Lyme disease spirochetes. Yale J. Biol. Med. 57:609–612.

    PubMed  CAS  Google Scholar 

  34. Kornblatt, AN., Steere, A.C. and Brownstein, D.G. 1984. Experimental Lyme disease in rabbits: Spriochetes found in erythema migrans and blood. Infect. Immun. 46:220–223.

    PubMed  CAS  Google Scholar 

  35. Barthold, S.W., Moody, K.D., and Terwillinger, G.A. 1988. An animal model for Lyme arthritis. Ann. NY Acad. Sci. 539:254–273.

    Google Scholar 

  36. Barthold, S.W., Moody, K.D., and Terwillinger. 1988. Experimental Lyme arthritis in rats infected with Borrelia burgdorferi. J. Infect. Dis. 157:842–846.

    Article  PubMed  CAS  Google Scholar 

  37. Schmitz, J.L., Schell, R.F. and Hejka, A. 1988. Introduction of Lyme arthritis in LSH hamsters. Infect Immunol. 56:2236–2342.

    Google Scholar 

  38. Hejka, A., Schmitz, J.L., England, D.M. 1989. Histopathology of Lyme arthritis in LSH hamsters. Am. J. Path. 134:1113–1123.

    PubMed  CAS  Google Scholar 

  39. Lissman, B.A. 1990. Lyme disease in small animals. NJ Med 87:573–574.

    CAS  Google Scholar 

  40. Magnarelli, L.A., Anderson, J.F., Levine, H.R. and Levy, S.A. 1990. Tick parasitism and antibodies to Borrelia burgdorferi in cats. J.A.V.M.A. 197:63–66.

    CAS  Google Scholar 

  41. Burgess, E.C. 1992. Experimentally induced infection in cats with Borrelia burgdorferi. Am. J. Vet. Res. 53:1507–1511.

    PubMed  CAS  Google Scholar 

  42. Burgdorfer, W., Barbour, A.G., Hayes, S.F., et al. 1982. Lyme disease — a tick-borne spirochetosis? Science. 216:1317–1319.

    Article  PubMed  CAS  Google Scholar 

  43. Barbour, A.G., Tessier, S.L. and Todd, W.J. 1983. Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by monoclonal antobody. Infect. Immun. 41:795804.

    Google Scholar 

  44. Envall, E. and Perlmann, P. 1972. Enzyme-linked immunosorbent assay, ELISA. II. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen coated tubes. J. Immunol. 109:129–135.

    Google Scholar 

  45. Burgess, E.D. 1992. Experimentally induced infection of cats with Borrelia burgdorferi. Am. J. Vet. Res. 53:1507–1511.

    PubMed  CAS  Google Scholar 

  46. Magnarelli, L.A., Meegan, J.M., Anderson, J.F., et al. 1984. Comparison of indirect fluorescent antibody test with an enzyme-linked immunosorbent assay for serological studies of Lyme disease. J. Clin. Micro. 20:181–184.

    CAS  Google Scholar 

  47. Duray, P.H. 1992. Target organs of Borrelia burgdorferi infections: Functional responses and histology. In: Lyme disease molecular and immunologic approaches. Scutzer, S.E., ed. Lold Spring Harbor Laboratory Press, New York, p.11–30.

    Google Scholar 

  48. Goellner, M.H., Agger, W.A, and Duray, P.H. 1988. Hepatitis due to recurrent Lyme disease. Ann. Intern. Med. 108:707.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gibson, M.D., Omran, M.T., Young, C.R. (1995). Experimental Feline Lyme Borreliosis as a Model for Testing Borrelia Burgdorferi Vaccines. In: Atassi, M.Z., Bixler, G.S. (eds) Immunobiology of Proteins and Peptides VIII. Advances in Experimental Medicine and Biology, vol 383. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1891-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1891-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5771-1

  • Online ISBN: 978-1-4615-1891-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics