Abstract
The eradication of malaria was conceived in the mid-1950s as an activity of limited duration. With the recognition in the late 1960s that eradication was not feasible, attention turned to control and newer approaches to combat this major cause of human misery. According to published estimates, malaria parasites annually infect 250 to 300 million people, cause 100-120 million clinical cases, and kill 1 to 2 million people. Including recent estimates of malaria from sub-Saharan Africa, these numbers could be as high as 500-900 million infections annually. Insecticide resistance in the mosquitoes, drug resistance in the parasites are, among many others (poverty, ignorance, social disruptions and often inadequate national resources, etc.), major causes for resurgence of malaria worldwide (Oaks et al. 1991). Over the last 20 years, major scientific advances have been made in the understanding of the immuno-biology of host-parasite interactions. The major goal of malaria research at the molecular and immunological fronts has been the identification and characterization of vaccine candidates.
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Kumar, N., Ploton, I., Koski, G., Ann-Lobo, C., Contreras, C. (1995). Malaria Transmission-Blocking Immunity. In: Atassi, M.Z., Bixler, G.S. (eds) Immunobiology of Proteins and Peptides VIII. Advances in Experimental Medicine and Biology, vol 383. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1891-4_8
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DOI: https://doi.org/10.1007/978-1-4615-1891-4_8
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