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Influence of the Anterior Chamber of The Eye on T-Cell Production of Extracellular Antigen-Specific Proteins

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Immunobiology of Proteins and Peptides VIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 383))

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Abstract

Analysis of the immunobiological properties of the anterior chamber (AC) of the eye has shown that the “immunologic privilege” of this region is due to a complex interaction of factors which influence both the immune response within the AC, and the systemic immune response. The introduction of soluble or particulate antigens into the AC results in a modulation of the systemic immune response which is manifested by stimulation of IgM and IgGI antibody production, and by suppression of delayed-type hypersensitivity and IgG2a antibody production. This so-called Anterior Chamber Associated Immune Deviation (ACAID, 1-6) response thus provides a major basis for the “immunologic privilege” of the AC by exerting a profound influence on systemic immunity, which, of course, includes the eye.

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Authors and Affiliations

  1. Vision-Immunology Center, Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, 06030-3105, USA

    Robert E. Cone, C. Hadjikouti, Y. Wang & J. O’Rourke

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  1. Robert E. Cone
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  2. C. Hadjikouti
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  3. Y. Wang
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  4. J. O’Rourke
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

  2. Univax Biologics, Inc., Rockville, Maryland, USA

    Garvin S. Bixler Jr.

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© 1995 Springer Science+Business Media New York

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Cone, R.E., Hadjikouti, C., Wang, Y., O’Rourke, J. (1995). Influence of the Anterior Chamber of The Eye on T-Cell Production of Extracellular Antigen-Specific Proteins. In: Atassi, M.Z., Bixler, G.S. (eds) Immunobiology of Proteins and Peptides VIII. Advances in Experimental Medicine and Biology, vol 383. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1891-4_25

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  • DOI: https://doi.org/10.1007/978-1-4615-1891-4_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5771-1

  • Online ISBN: 978-1-4615-1891-4

  • eBook Packages: Springer Book Archive

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