Abstract
Tear sialomucins are of prime importance for the wettening of the cornea. So far their production almost unanimously has been allocated by other authors to the conjunctival goblet cells. However, two major bodies of findings led us to question the prime importance of conjunctival goblet cells for an appropriate tear attachment to the corneal surface1. First, and according to other authors, Dry Eye syndromes are not always associated with a marked reduction of conjunctival goblet cells2. Second, own previous lectin-histochemical investigations on the main and accessory lacrimal glands have documented considerable glycoprotein expression, amongst them different types of sialomucins, also in these organs3–5. In addition, electrophoretic analyses revealed different sialomucins in human tears6,7.
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References
F.J. Holly and M.A. Lemp, Wettability and wetting of corneal epithelium, Exp. Eye Res. 11:239–250 (1971).
S.K. Kinoshita, T.C. Kiorpes, and J. Friend, R.A. Thoft, Goblet cell density in ocular surface disease,Arch. Ophthal. (Chicago) 101:1284–1287(1983).
W. Breipohl, M. Spitznas, F. Sinowatz, O. Leip, W. Naib-Majani, and A. Cusumano, Galactose-binding sites in the acinar cells of the human accessory lacrimal gland, In: Lacrimal gland, tear film and dry eye syndromes, D. Sullivan, ed., Plenum, New York -London, pp 45 -48 (1994).
W. Breipohl, W. Naib-Majani, F. Sinowatz, T. Naguro, and A. Wegener, Sialomucin expression in the human accessory lacrimal gland, In: Sjögrens Syndrome. State of the Art, M. Homma M. et al., eds, Kugler, Amsterdam -New York, pp 553 -557 (1994).
W. Breipohl, W. Naib-Majani, and U. Sterzinsky, Classification of glycoprotein expression in human conjunctival, main and accessory tear gland cells, Invest. Ophthalmol. Vis. Sc. 35:1795 (1994).
W. Breipohl, C. Reitz, M.H.J. Ahrend, F.H. Grus, and J. Bours, Characterization of human tear gly-coproteins by Phast electrophoresis, western blotting and lectin binding, This Volume.
A. Kuizenga, N.J. van Haeringen, and A. Kijlstra, Identification of lectin binding proteins in human tears, Invest. Ophthalmol. Vis. Sci. 32:3277–3284 (1991).
L. Hazlett, D. Dudzik, and B. Harries, Development of ocular mucin: scanning EM analysis, Ophthalmic Res. 18:28–33 (1986).
K. Bjerrum, P. Halken, and J.U. Prause, The normal tear glycoprotein profile detected with lectin probes, Exp. Eye Res. 53:431–435 (1991).
A. Kuizenga, E.J. van Agtmaal, N.J. van Haeringen, and A. Kijlstra, Sialic acid in human tear fluid,Exp. Eye Res. 50:45–50 (1990).
O.A. Jensen, I. Falbe-Hansen, T. Jacobsen, and A. Michelsen, Mucosubstances of the acini of the human lacrimal gland (orbital part). I. Histochemical identification, Acta Ophthalmol. 47:605–619 (1969).
I. Falbe-Hansen, O.A. Jensen, and D.J. Karossa, Mucosubstances of the acini of the human lacrimal gland (orbital part). II. Biochemical identification, Acta Ophthalmol. 47:620–627 (1969).
G. Spik, G. Strecker, B. Fournet, and S.B. Montreuil, Primary structure of the glycans from human lactotransferrin, Europ. J. Biochem. 121:413–419 (1982).
A.T. Sapse, B. Bonavida, W. Stone jr., and E.E. Sercarz, Proteins in human tears, Arch. Ophthal.81:815–819 (1969).
A. Kuizenga, Identification and characterization of proteins in human tear fluid, Academisch Proefschrift, Amsterdam, (1992).
A. Kluge, G. Reuter, H. Lee, B. Ruch-Heeger, and R. Schauer, Interaction of rat peritoneal macrophages with homologous sialidase-treated thrombocytes in vitro: biochemical and morphological studies. Detection of N-(O-acetyl)glycoloylneuraminic acid, Europ. J. Cell Biol. 59:12–20 (1992).
R.L. Miller, A sialic acid-specific lectin from the slug Limax flavus ,J. Invertebrate Path. 39:210–214 (1982).
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Naib-Majani, W., Breipohl, W., Sterzinsky, U., Takeda, M. (1995). Characterization of Sialomucins Expressed by Human Conjunctival Goblet Cells. In: Weisse, I., Hockwin, O., Green, K., Tripathi, R.C. (eds) Ocular Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1887-7_31
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DOI: https://doi.org/10.1007/978-1-4615-1887-7_31
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