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The ERG, EOG, and VEP in Rats

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Abstract

The critical analysis of the physiological, functional, and anatomical responses of the eye to the introduction of exogenous compounds is an integral part of many toxicity studies. Clinical studies conducted with biomicroscopy, indirect ophthalmoscopy, and histopathology allow for the detection of anatomical changes. Electrophysiology and psychophysics provide functional measures of the visual system that complement anatomical analysis.

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References

  • Alpern, M., Fulton, A.B., and Baker, B.N. 1987. “Self-screening” of rhodopsin in rod outer segments. Vis. Res. 27: 1459–1470.

    Article  PubMed  CAS  Google Scholar 

  • Arito, H., Tsuruta, H., and Oguri, M. 1988. Changes in sleep and wakefulness following single and repeated exposures to toluene vapor in rats. Toxicology 62: 76–80.

    CAS  Google Scholar 

  • Bach, M., Gerling, J., and Geiger, K. 1992. Optic atrophy reduces the pattern-electroretinogram for both fine and coarse stimulus patterns. Clin. Vis. Sci. 7: 327–333.

    Google Scholar 

  • Balkema, G.W. 1988. Elevated dark-adapted thresholds in albino rodents. Invest. Ophthal. Vis. Sci. 29: 544–549.

    PubMed  CAS  Google Scholar 

  • Bartel, P., Blom, M., Robinson, E. Van der Meyden, C., Sommers, DeK., and Becker, P. 1990. Effects of chlorpromazine on pattern and flash ERGs and VEPs compared to oxazepam and to placebo in normal subjects. Electroenc. Clin. Neurophvs. 77: 330–339.

    Article  CAS  Google Scholar 

  • Benignus, V.A., Boyes, W.K., Hudnell, H.K., Frey, C.M., Svendsgaard, D.J. 1991. Quantitative methods for cross-species mapping (CSM). Neurosci. and Behav. Rev. 15: 165–171.

    Article  CAS  Google Scholar 

  • Berninger, T.A. and Arden, G.B. 1988. The pattern electroretinogram. Eve 2, suppl.: s257–s283.

    Google Scholar 

  • Birch, D.G. 1989. Clinical electroretinography. Ophthal. Clinics of North America 2: 469–497.

    Google Scholar 

  • Bichsel, P., Oliver, J., Coulter, D., and Brown, J. 1988. Recording of visual-evoked potentials in dogs with scalp electrodes. J. Vet. Int. Med. 2: 145–149.

    Article  CAS  Google Scholar 

  • Borel, L., and Lacour, M. 1992. Functional coupling of the stabilizing eye and head reflexes during horizontal and vertical linear motion in the cat. Exp. Brain Res. 91: 191–206.

    Article  PubMed  CAS  Google Scholar 

  • Boyes, W.K. 1990. Proposed test guidelines for using sensory evoked potentials as measures of neurotoxicity, U.S.E.P.A. Document: EPA/600/x-90/166.

    Google Scholar 

  • Boyes, W.K. 1992. Testing visual system toxicity using evoked potential technology, in R.L. Isaacson and K.F. Jenson, eds. The Vulnerable Brain and Environmental Risks, Volume 1. Plenum Press, New York.

    Google Scholar 

  • Boyes, W.K., and Dyer, R.S. 1983a. Pattern reversal visual evoked potentials in awake rats. Br. Res. Bull. 10:817–823.

    Article  CAS  Google Scholar 

  • Boyes, W.K., and Dyer, R.S. 1983b. Pattern reversal and flash evoked potentials following acute triethyltin exposure. Neurobehav. Toxicol. Teratol. 5: 571–577.

    PubMed  CAS  Google Scholar 

  • Boyes, W.K., and Dyer, R.S. 1984. Chlordimeform produces profound, selective, and transient changes in visual evoked potentials of the hooded rat. Exp. Neurology 86: 434–447.

    Article  CAS  Google Scholar 

  • Boyes, W.K., and Dyer, R.S. 1988. Visual evoked potentials as indicators of neurotoxicity. Office of Research and Development, U.S.E.P.A., Deliverable 2312A, Document number HERO653.

    Google Scholar 

  • Boyes, W.K., Jenkins, D., and Dyer, R.S. 1985. Chlordimeform produces contrast-dependent changes in visual evoked potentials of the hooded rat. Exp. Neurol. 89: 434–449.

    Article  Google Scholar 

  • Boyes, W.K., Tandon, P., Barone, S., and Padilla, S. 1994. Effects of organophosphates on the visual system of rats. J. AppI. Tox. 14: 135–143.

    Article  CAS  Google Scholar 

  • Breton, M., Schueller, A.W., Lamb, T.D., and Pugh, E.N. 1993. Analysis of ERG a-wave amplification and kinetics in terms of the g-protein cascade of phototransduction. Inv. Ophthal. Vis. Sci. 35: 295–309.

    Google Scholar 

  • Burchfield, D.J., Graham, E.M., Abrams, R.M., and Gerhardt, K.J. 1990. Cocaine alters behavioral states in the fetal sheep. Develop. Brain Res. 56: 41–45.

    Article  CAS  Google Scholar 

  • Bush, R.A. and Reme, C.E. 1992. Chronic lithium treatment induces reversible and irreversible changes in the rat ERG in vivo. Clin. Vis. Sci. 7: 393–401.

    Google Scholar 

  • Butler, S.R., Ford, G.P., and Newbern, J.W. 1987. A study of the effects of vigabatrin on the central nervous system and retina of Sprague-Dawley and Lister-hooded rats. Toxicol. Pathol. 15: 143–148.

    Article  PubMed  CAS  Google Scholar 

  • Chang, L.W., and Dyer, R. 1983. Trimethyltin induced pathology in sensory neurons. Neurobehav. Toxicol. Teratol. 5: 337–350.

    PubMed  CAS  Google Scholar 

  • Chuang, H.C., Kawano, S., Arai, M., Tsukada, T., Kita, M., Negi, A., and Honda, Y. The influence of argon laser panretinal photocoagulation on the rabbit ERG c-wave. Acta Ophthalmologica 70: 303–307.

    Google Scholar 

  • Cideciyan, A. and Jacobson, S.G. 1994. Negative electroretinograms in retinitis pigmentosa. Inv. Ophthal. Vis. Sci. 34: 3253–3263.

    Google Scholar 

  • Cillino, S., Guarneri, R., Guarneri, P., Pennica, C., Chichi, G., Piccoli, F., and Ponte, P. 1993. Electroretinographic Response in WAG/Rij rats after low-intensity cyclic light exposure. Ophthalmic Res. 25: 137–144.

    Article  PubMed  CAS  Google Scholar 

  • Creel, DJ. 1973 Visually evoked responses in the rat, guinea pig, cat, monkey, and man. Exp. Neurol. 40: 351–366.

    Article  PubMed  CAS  Google Scholar 

  • Creel, DJ. 1984. Albinism and evoked potentials: factors in the selection of infrahuman models to predicting the human response to neurotoxic agents. Neurobeh. Tox. and Terat. 6: 447–453.

    CAS  Google Scholar 

  • Crofton, K.M., and Sheets, L.P. 1989. Evaluation of sensory system function using reflex modification of the startle response. J. Am. Coll. Toxicol. 8: 199–211.

    Article  Google Scholar 

  • Deguchi, K., Takeuchi, H., Mild, H., Yamada, A., Touge, T., Terada, S., and Nishioka, M. 1992. Electrophysiological follow-up of acute and chronic experimental allergic encephalomyelitis in the Lewis rat. Eur. Arch. Psychiatry Clin. Neurosci. 242: 1–5.

    Article  PubMed  CAS  Google Scholar 

  • Dementi, B. 1994. Ocular effects of organophosphates: a historical perspective of Saku disease. J. Appl. Tox. 14: 119–129.

    Article  CAS  Google Scholar 

  • Domenici, L., Gravina, A., Berardi, N., and Maffei, L. 1991. Different effects of intracranial and intraorbital section of the optic nerve on the functional responses of rat retinal ganglion cells. Exp. Br. Res. 86:579–584.

    Article  CAS  Google Scholar 

  • Drasdo, N., Cox, W., and Thompson, D.A. 1987a. The effects of image degradation on retinal illuminance and pattern responses to checkerboard stimuli. Doc. Ophthal. 66: 267–275.

    Article  CAS  Google Scholar 

  • Drasdo, N., Thompson, D.A., Thompson, C.M., and Cox, W. 1987b. Complementary components and local variations of the pattern electroretinogram. Inv. Ophthal. Vis. Sci. 28: 158–162.

    CAS  Google Scholar 

  • Dyer, R.S. 1986. Interactions of behavior and neurophysiology. In Z. Annau (ed.) Neurobehavioral Toxicology. Johns Hopkins Univ. Press, pp. 193–213.

    Google Scholar 

  • Dyer, R.S., Bercegeay, M.S., and Mayo, L.M. 1988 Acute exposures to p-xylene and toluene alter visual information processing. Neurotoxicol. and Teratol. 10: 147–153.

    Article  CAS  Google Scholar 

  • Dyer, R.S., and Boyes, W.K. 1983. Hypothermia and chloropent anesthesia differentially affect the flash evoked potentials of hooded rats. Brain Res. Bull. 10: 825–831.

    Article  PubMed  CAS  Google Scholar 

  • Dyer, R.S., Boyes, W.K., and Hetzler, B.E. 1986. Acute sulfolane exposure produces temperature-independent and dependent changes in visual evoked potentials. Neurobehav. Toxicol. Teratol. 8: 687–693.

    PubMed  CAS  Google Scholar 

  • Dyer, R.S., Eccles, C.U., and Annau, Z. 1978. Evoked potential alterations following prenatal methyl mercury exposure. Pharmacol. Biochem. Behav. 8: 137–141.

    Article  PubMed  CAS  Google Scholar 

  • Dyer, R.S. and Howell, W.E. 1982a. Acute triethyltin exposure: effects on the visual evoked potential and hippocampal afterdischarge. Neurobehav. Toxicol. Teratol. 4: 259–266.

    PubMed  CAS  Google Scholar 

  • Dyer, R.S. and Howell, W.E. 1982b. Triethyltin: ambient temperature alters visual system toxicity. Neurobehav. Toxicol. Teratol. 4: 267–271.

    PubMed  CAS  Google Scholar 

  • Dyer, R.S., and Rigdon G.C. 1987. Urethane affects the rat visual system at subanesthetic doses. Phvsiol. and Behav. 41: 327–330.

    Article  CAS  Google Scholar 

  • Dyer, R.S., and Swartzwelder, H.S. 1978. Sex and strain differences in the visual evoked potentials of albino and hooded rats. Pharmocol. Biochem. Behav. 9: 301–306.

    Article  CAS  Google Scholar 

  • el Azazi, M., and Wachtmeister, L. 1990. The postnatal development of the oscillatory potentials of the electroretinogram. I. Basic characteristics. Acta Ophtalmologica 68: 401–409.

    Article  Google Scholar 

  • el Azazi, M., and Wachtmeister, L. 1991a. The postnatal development of the oscillatory potentials of the electroretinogram. II. Photopic characteristics. Acta Ophtalmologica 69: 6–10.

    Article  Google Scholar 

  • el Azazi, M., and Wachtmeister, L. 1991b. The postnatal development of the oscillatory potentials of the electroretinogram. III. Scotopic characteristics. Acta Ophthalmologica 69: 505–510.

    Article  PubMed  Google Scholar 

  • el Azazi, M., and Wachtmeister, L. 1992. The postnatal development of the oscillatory potentials of the electroretinogram. IV. Mesopic characteristics. Acta Ophthalmologica 70: 194–200.

    Article  PubMed  Google Scholar 

  • Erny, B.C., Wexler, D.B., and Moore-Ede, M.C. 1985. Sleep-wake stages during the subjective night of the squirrel monkey. Physiology and Behav. 35: 189–194.

    Article  CAS  Google Scholar 

  • Finkelstein, M.A. and Gouras, P. 1969. Visual electrophysiology: an introduction to the ERG, EOG, ERP, and VER, in S.J.Fricker, ed., Electrical Response of the Visual System (LO.C. 914), pp. 857–881.

    Google Scholar 

  • Fishman, G.A. 1990. The Electro-oculogram in retinal disorders. In Fishman, G.A., and Sokol, S. (eds.) Electrophysiologic Testing in Disorders of the Retina, Optic Nerve, and Visual Pathway. p.95. American Academy of Ophthalmology. San Francisco, C.A.

    Google Scholar 

  • Flandrin, J.M., Courjon, J.H., Magnin, M., and Arzi, M. 1990. Horizontal optokinetic responses under stroboscopic illumination in cat, monkey, and man. Exp. Brain Res. 81: 59–69.

    Article  PubMed  CAS  Google Scholar 

  • Fox, D.A. and Farber, D.B. 1988. Rods are selectively altered by lead: I. Electrophysiology and biochemistry. Exp. Eye Res. 46: 597–611.

    Article  PubMed  CAS  Google Scholar 

  • Fox, D.A. and Katz, L.M. 1992. Developmental lead exposure selectively alters the scotopic ERG component of dark and light adaptation and increases rod calcium content. Vis. Res. 32: 249–255.

    Article  PubMed  CAS  Google Scholar 

  • Fox, D.A., Katz, L.M., and Farber, D.B. 1991. Low level developmental lead exposure decreases the sensitivity, amplitude, and temporal resolution of rods. Neurotoxicol. 12: 641–654.

    CAS  Google Scholar 

  • Fox, D.A. and Rubinstein, S.D. 1989. Age-related changes in retinal sensitivity, rhodopsin content and rod outer segment length in hooded rats following low-level lead exposure during development. Exp. Eve Res. 48: 237–249.

    Article  CAS  Google Scholar 

  • Ghilardi, M.F., Marx, M.S., Onofrj, M.C., Glover, A.A., and Bodis-Wollner, I. 1987. Scalp distribution of pattern visual evoked potentials in normal and hemianopic monkeys. Physiology and Behav. 41: 297–302.

    Article  CAS  Google Scholar 

  • Gitter, S., Pardo, A., Kariv, N., and Yinon, U. 1988. Enhanced electroretinogram in cats induced by exposure to mercury acetate. Toxicology 51: 67–76.

    Article  PubMed  CAS  Google Scholar 

  • Gramoni, R. 1980. Retinal function of rats exposed to organomercurials. In Merigan, W.H., and Weiss, B. (eds.) Neurotoxicity of the Visual System. Raven Press, N.Y.

    Google Scholar 

  • Grant, W.M. 1986. Toxicology of the Eye, third edition. Charles E. Thomas, Springfield, IL.

    Google Scholar 

  • Graves, A., Green, D.G., and Fisher, L.J. 1985. Light exposure can reduce selectively or abolish the c-wave of the albino rat electroretinogram. Invest. Ophthal. Vis. Sci. 26: 388–393.

    PubMed  CAS  Google Scholar 

  • Green, D.G. 1973. Scotopic and photopic components of the rat electroretinogram. J. Phvsiol. 228. 781–797.

    CAS  Google Scholar 

  • Green, D.G., Herreros de Tejada, P., and Glover, M.J. 1991. Are albino rats night blind? Invest. Ophthal. Vis. Sci. 32: 2366–2371.

    PubMed  CAS  Google Scholar 

  • Green, D.G., Powers, M.K., and Banks, M.S. 1980. Depth of focus, eye size, and visual acuity. Vis. Res.20: 827–835.

    Article  PubMed  CAS  Google Scholar 

  • Hawks, K.W., Bush, R.A., and Sieving, P.A. 1994. STR shows disproportionate loss compared to PII in RCS rat. Inv. Ophthal. Vis. Sci., suppl. 35: 2045.

    Google Scholar 

  • Hawlina, M., and De Villiers, P.L.G. 1992. Light-emitting diodes and half-cell electrodes in experimental recording of electroretinogram c-wave. Doc. Ophthal. 81: 227–237.

    Article  CAS  Google Scholar 

  • Hendricks, J.C., Kovalski, R.J., and Kline, L.R. 1991. Phasic respiratory muscle patterns and sleep-disordered breathing during rapid eye movement sleep in the English bulldog. Am. Rev. Respir. Dis. 144: 1112–1120.

    Article  PubMed  CAS  Google Scholar 

  • Herr, D.W. and Boyes, W.K., 1993. Potential confounding effects of strobe “clicks” in flash evoked potentials (FEPs) in rats. Toxicologist 13 (abstract): 216.

    Google Scholar 

  • Herr, D.W. and Boyes, W.K., in press. Electrophysiological analysis of complex brain systems: sensory evoked potentials and their generators.

    Google Scholar 

  • Herr, D.W., Boyes, W.K., and Dyer, R.S. 1991. Rat flash evoked potential peak N160 amplitude: Modulation by relative flash intensity. Phvsiol. Behav. 49: 355–365.

    Article  CAS  Google Scholar 

  • Herr, D.W., Dyer, R.S., and Boyes, W.K. 1992. Alterations in rat flash and pattern reversal evoked potentialsafter acute or repeated administration of carbon disulfide (CS2). Fund. Appl. Toxicol. 18: 328–42.

    Article  CAS  Google Scholar 

  • Herreros de Tejada, P., Green, D.G., and Muñoz Tedo, C. 1992. Visual thresholds in albino and pigmented rats. Visual Neurosci. 9: 409–414.

    Article  Google Scholar 

  • Hess, R.F., and Baker, C.L. 1984. Human pattern-evoked electroretinogram. J. Neurophvs.51: 939–951

    CAS  Google Scholar 

  • Hetzler, B., and Dyer, R.S. 1984. Contribution of hypothermia to effects of chloral hydrate on flash evoked potentials of hooded rats. Pharmacol. Biochem. Behavior 21: 599–607.

    Article  CAS  Google Scholar 

  • Hetzler, B.E., Boyes, W.K., Creason, J.P., and Dyer, R.S. 1988. Temperature-dependent changes in visual evoked potentials of rats. Electroenc. Clin. Neurophvs. 70: 137–154.

    Article  CAS  Google Scholar 

  • Hetzler, B.E., and Norris, L.K. 1988. Pentobarbital produces temperature-independent and dependent changes in the visual evoked potentials of rats. Annual Society for Neuroscience Abstracts, Toronto.

    Google Scholar 

  • Heynen, H., Wachmeister, L., and van Norren, D. 1985. Origin of the oscillatory potentials in the primate retina. Vis. Res. 25: 1365.

    Article  PubMed  CAS  Google Scholar 

  • Hey wood, R., and Gopinath, C. 1990. Morphological assessment of visual dysfunction. Toxicol. Pathol. 18:204–217.

    Google Scholar 

  • Hodgkins, P.R., Morrell, A.J., Luff, A.J., Fetherston, T.J., and Good, P. 1992. Pigment epitheliopathy with serous detachment of the retina following intravenous iron dextran. Eve 6: 414–415.

    Google Scholar 

  • Hood, D.C. and Birch, D.G. 1990. The a-wave of the human electroretinogram and rod receptor function. Invest. Qphtfaal. Vis. Sci. 31: 2070–2081.

    CAS  Google Scholar 

  • Hood, D.C. and Birch, D.G. 1993a. Light adaptation of human rod receptors: the leading edge of the human a-wave and models of rod receptor activity. Vis. Res. 33: 1605–1618.

    Article  PubMed  CAS  Google Scholar 

  • Hood, D.C. and Birch, D.G. 1993b. The human rod a-wave and phototransduction: interpreting the fit of the Lamb and Pugh model. Vis. Sci. and Applic. Tech. Digest (OSA).

    Google Scholar 

  • Hubbard, N.P. and Naarendorp, F. 1994. Effects of dim background lights on the scotopic threshold response of the rat ERG. Inv. Ophthal. Vis. Sci., suppl. 35: 2047.

    Google Scholar 

  • Hudnell, H.K. and Boyes, R. 1991. The comparability of rat and human visual-evoked potentials. Neurosci. Biobehav. Rev. 15: 159–164.

    Article  PubMed  CAS  Google Scholar 

  • Hudnell, H.K., Boyes, W.K., and Otto, D.A. 1990. Rat and human visual -evoked potentials recorded under comparable conditions: a preliminary analysis to address the issue of predicting human neurotoxic effects from rat data. Neurotox. and Teratology 12: 391–398.

    Article  CAS  Google Scholar 

  • Imai, H., Miyata, M., Uga, S., and Ishikawa, S. 1983. Retinal degeneration in rats exposed to an organophosphate pesticide (fenthion). Environ. Res. 30: 453–465.

    Article  PubMed  CAS  Google Scholar 

  • Imai, R. and Tanakamaru, Z. 1993. Visual dysfunction in aged Fischer 344 rats. J.Vet. Med. Sci. 55: 367–370.

    Article  PubMed  CAS  Google Scholar 

  • Jarkman, S., Skoog, K., and Nilsson, S.E. 1985. The c-wave of the electroretinogram and the standing potential of the eye as highly sensitive measures of effects of low doses of trichloroethylene, methylchloroform, and halothane. Doc. Ophthal. 60: 375–382.

    Article  CAS  Google Scholar 

  • Johnson, M.A., and Massof, R.W. 1982. The photomyoclonic reflex: an artifact in the clinical electroretinogram. Br. J. Ophthal. 66: 368–378.

    Article  CAS  Google Scholar 

  • Kametani, H., and Kawamura, H. 1990. Alterations in acetylcholine release in the rat hippocampus during sleep-wakefulness detected by intracerebral dialysis. Life Sci. 47: 421–426.

    Article  PubMed  CAS  Google Scholar 

  • Katz, L.M., and Fox, D.A. 1991. Prenatal ethanol exposure alters scotopic and photopic components of adult rat electroretinograms. Invest. Ophthal. Vis. Sci. 32: 2861–2872.

    PubMed  CAS  Google Scholar 

  • Kiyosawa, I., Aoki, M., Imamura, T., Naito, J., Saito, T.R., and Takahashi, K.W. 1993. Comparison of the gold wire electrode with cotton wick electrode for electroretinography in small laboratory animals. Exp. Anim. 42: 129–133.

    CAS  Google Scholar 

  • Kommonen, B., Karhunen, U., and Raitta, C. 1988. Effects of thiopentone halothane-nitrous oxide anaesthesia compared to ketamine-xylazine anaesthesia on the dc recorded dog electroretinogram. Acta Vet. Scand. 29: 23–33.

    PubMed  CAS  Google Scholar 

  • Kovalzon, V.M., Obal, FJr., and Kalikhevich, V.N. 1986. [Peptidergic modulation of sleep: a comparative study of analogs of the peptide DSIP]. Zh. Evol. Biokhim. Fiziol. 22: 483–488.

    CAS  Google Scholar 

  • Kraut, M.A., Arezzo, J.C., and Vaughan Jr., H.G. 1985. Intracortical generators of the flash VEP in monkeys. Electroenc. Clin. Neurophvs. 62: 300–312.

    Article  CAS  Google Scholar 

  • Lachapelle, P., Benoit, J., Little, J.M., and Faubert, J. 1990. The diagnostic use of the second oscillatory potential in clinical electroretinography. Doc. Ophthal. 73: 327–336.

    Article  Google Scholar 

  • Lachapelle, P., and Blain, L. 1990. A new speculum electrode for electroretinography. J. Neurosci. Meth. 32: 245–249.

    Article  CAS  Google Scholar 

  • Larsby, B., Tham, R., Eriksson, B., and Odkvist, L.M. 1986. The effect of toluene on the vestibulo- and optooculomotor system in rats. Acta Otolarvngol. (Stockh.) 101: 422–428.

    Article  CAS  Google Scholar 

  • Maertins, T., Kroetlinger, F., Sander, E., Pauluhn, J., and Machemer, L. 1993. Electroretinographic assessment of early retinopathy in rats. Arch. Toxic. 67: 120–125.

    Article  CAS  Google Scholar 

  • Maffei, L., and Fiorentini, A. 1981. Electroretinographic responses to alternating gratings before and after section of the optic nerve. Science 211: 953–955.

    Article  Google Scholar 

  • Maffei, L., and Fiorentini, A. 1990. The pattern electroretinogram in animals and humans: physiological and clinical applications. In Cohen, B., and Bodis-Wollner, I. (eds.) Vision and the Brain. Raven Press,N.Y.

    Google Scholar 

  • Mamelak, A.N., Quattrochi, J.J., and Hobson, J.A. 1991. Automated staging of sleep in cats using neural networks. Electroenceph. Clin. Neurophvs. 79: 52–61.

    Article  CAS  Google Scholar 

  • Marini, G., Gritti, I., and Mancia, M. 1992. Enhancement of tonic and phasic events of rapid eye movement sleep following bilateral ibotenic acid injections into the centralis lateralis thalamic nucleus of cats. Neurosci. 48: 877–888.

    Article  CAS  Google Scholar 

  • Maruiwa, F., Kim, S.D., Nao-I, N., and Sawada, A. 1992. [Effects of metoclopramide, dopamine receptor blocker, on the EOG light peak]. Nippon Ganka Gakkai Zasshi 96: 375–380.

    PubMed  CAS  Google Scholar 

  • Massof, R.W., and Jones, A.E. 1972. Electroretinographic evidence for a photopic system in the rat. Vis. Res. 12: 1231–1239.

    Article  PubMed  CAS  Google Scholar 

  • Menon, I.A., Trope, G.E., Basu, P.K., Wakeham, D.C., and Persad, S.D. 1989. Binding of tiomol to iris ciliary body and melanin: an in vitro model for assessing kinetics and efficacy of long acting antiglaucoma drugs. J. Ocul. Pharmacol. 5: 313–324.

    Article  PubMed  CAS  Google Scholar 

  • Millar, T.J., Vaegan, and Arora, A. 1989. Urethane as a sole general anesthetic in cats used for electroretinographic studies. Neurosci. Lett. 103: 108–112.

    Article  PubMed  CAS  Google Scholar 

  • Mondelski, S. 1991. [Polish contribution to the electrophysiological studies in ophthalmology. I. Technology and animal studies]. Klin Oczna. 93: 94–96.

    PubMed  CAS  Google Scholar 

  • Mustonen, E. and Sulg, I. 1980. Electroretinography by skin electrodes and signal averaging method. Acta Qphthal. 58: 388–396.

    Article  CAS  Google Scholar 

  • Nakatake, N., Hori, A., Yasuhara, A., Naito, H., and Yasuhara, M. 1993. Oscillatory potentials of visual evoked potentials using source derivation techniques in rabbits. J. Neurolog. Sci. 114:144–151.

    Article  CAS  Google Scholar 

  • Nao-I, N, Kim, S., and Honda, Y. 1986. The normal c-wave amplitude in rabbits. Doc. Qphthal. 63: 121–130.

    Article  CAS  Google Scholar 

  • Narfstrom, K., Arden, G.B., and Nilsson, S.E.G. 1989. Retinal sensitivity in hereditary retinal degeneration in Abyssinian cats: electrophysiological similarities between cat and man. Br. J. Qphthal. 73: 516–521.

    Article  CAS  Google Scholar 

  • Onofrj, M., Bodis-Wollner, I., and Bobak, P. 1982. Pattern evoked potentials in the rat. Phvsiol. Behav. 28: 227–230.

    Article  CAS  Google Scholar 

  • Pall, H., Blake, D.R., Winyard, P., Lunec, J., Williams, A., Good, P.A., Kritzinger, E.E., Cornish, A., and Hider, R.C. 1989. Ocular toxicity of desferrioxamine- an example of copper promoted auto-oxidative damage? Br. J. Qpthal. 73: 42–47.

    Article  CAS  Google Scholar 

  • Peachey, N.S., Alexander, K.R., Derlacki, D.J., Bobak, P., and Fishman, G.A. 1991. Effects of light adaptation on the response characteristics of human oscillatory potentials. Electroenc. Clin. Neurophvs. 78: 27–34.

    Article  CAS  Google Scholar 

  • Peiffer, R.L., Armstrong, J.R., and Johnson, P.T. 1981. Animals in ophthalmic research concepts and methodologies. In Gay, W.I. (ed.) Methods of Animal Experimentation v. 6. Academic Press, New York, p. 206.

    Google Scholar 

  • Penn, J.S., Thum, L.A., and Nash, M.I. 1989. Photoreceptor physiology in the rat is governed by the light environment. Exp. Eve Res. 49:205–215.

    Article  CAS  Google Scholar 

  • Peters, A.J., Abrams, R.M., Burchfield, D.J., and Gilmore, R.L. 1992. Seizures in a fetal lamb after cocaine exposure: a case report. Epilepsia 33:1001–1004.

    Article  PubMed  CAS  Google Scholar 

  • Pivik, R.T., Bylsma, F.W., and Cooper, P.M. 1987. Variations in nuchal tonus following paradoxical sleep deprivation in the rabbit. Brain Res. 423: 196–202.

    Article  PubMed  CAS  Google Scholar 

  • Rigdon, G.C., and Dyer, R.S. 1987. Ontogeny of flash-evoked potentials in unanesthetized rats. Int. J. Develop. Neurosci. 5: 447–454.

    Article  CAS  Google Scholar 

  • Rigdon, G.C., and Dyer, R.S. 1988. Ketamine alters rat flash evoked potentials. Pharmacol. Biochem. Behav. 30: 421–426.

    Article  PubMed  CAS  Google Scholar 

  • Romani, A., Callieco, R., Bergamaschi, R., Versino, M., Cosi, V. 1991. Visual evoked potentials in the white New Zealand rabbit: source localization and normative aspects. Boll. Soc. It. Biol. Sper. 67: 601–607.

    CAS  Google Scholar 

  • Rosner, M. Bobak, P., and Lam, T.L. 1993. Corneal electrode for recording electroretinograms in rats. Doc. Ophthal. 83: 175–180.

    Article  CAS  Google Scholar 

  • Rudolph, G. Wioland, N., Kempf., and Bonaventure, N. 1990. EOG and ERG modifications induced in the chicken eye after blockade of catecholamine and 5-hydroxytryptamine biosynthesis. Doc. Ophthal.76: 47–53.

    Article  Google Scholar 

  • Rudolph, G., Wioland, N., Kempf, E., and Bonaventure, N. 1989. Electrooculographic study in the chicken after treatment with neurotoxin 6-hydroxydopamine. Doc. Ophthal. 72: 83–91.

    Article  Google Scholar 

  • Sandberg, M.A. 1994. Objective assessment of retinal function. In Albert, D.M., and Jakobiec, F.A. (eds.) Principles and Practices of Ophthalmology: A Clinical Guide W.B. Sanders Co. p 1195–1196.

    Google Scholar 

  • Sandberg, M.A., Pawlyk, B.S., Crane, W.G., and Berson, E.L. 1988. Diurnal rhythm in the electroretinogram of the Royal College of Surgeons (RCS) pigmented rat. Exp. Eve Res. 46: 929–936.

    Article  CAS  Google Scholar 

  • Sato, T., Tadokoro, M., Kaba, H., Saito, H., Seto, K., and Takatsuji, H. 1993. Centrally administered ouabain aggravates central sleep apneas. J. Appl. Phvsiol. 74:545–548.

    CAS  Google Scholar 

  • Schroeder, C.E., Givre, S.J., and Tenke, C.E. 1990. Extrast4riate contributions to surface VEP in the awake macaque. Inv. Ophthal. Vis. Sci. (suppl.) 31: 258.

    Google Scholar 

  • Schroeder, C.E., Tenke, C.E., Givre, S.J., Arezzo, J.Z., and Vaughan, Jr., H.G. 1991. Striate cortical contribution to the surface-recorded pattern-reversal VEP in the alert monkey. Vis. Res. 31: 1143–1157.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, M. and Block, F. 1993. Visual evoed potentials in the rat quinolinic acid model of Huntington’s disease. Neurosci. Lett. 152: 81–83.

    Article  PubMed  CAS  Google Scholar 

  • Sieving, P.A. 1991. Retinal ganglion cell loss does not abolish the scotopic threshold response (STR) of the cat and human ERG. Clin Vis. Sei 6: 149–158.

    Google Scholar 

  • Sieving, P.A. and Bush, R.A. 1994. A proximal retinal component in the primate photopic ERG a-wave. Invest. Ophthal. Vis. Sci. 35: 635–645.

    PubMed  Google Scholar 

  • Sieving, P.A., Fishman, G.A., and Maggiano, J.M. 1978. Corneal wick electrode for recording bright flash electroretinograms and early receptor potentials. Arch. Ophthal. 96: 899–900.

    Article  PubMed  CAS  Google Scholar 

  • Sieving P.A., Frishman, L.J., and Steinberg, R.H. 1986. Scotopic threshold response of proximal retina in cat. J. Neurophvs. 56: 1049–1061.

    CAS  Google Scholar 

  • Sieving, P.A. and Nino, C. 1988. Scotopic threshold response (STR) of the human electroretinogram. Inv. Ophthal. Vis. Sci. 29: 1608–1614.

    CAS  Google Scholar 

  • Sieving, P.A. and Steinberg, R.H. 1987. Proximal retinal contribution to the intraretinal 8-Hz pattern ERG of the cat. J. Neurophvs. 57: 104–120.

    CAS  Google Scholar 

  • Sieving, P.A. and Wakabayashi, K. 1991. Comparison of rod threshold ERG from monkey, cat and human. Clin. Vis. Sci. 6: 171–179.

    Google Scholar 

  • Sims, M.H., and Laratta, L.J. 1988. Visual-evoked potentials in cats, using a light-emitting diode stimulator. Am. J. Vet. Res. 49: 1876–1881.

    PubMed  CAS  Google Scholar 

  • Solomon, D. and Cohen, B. 1992. Stabilization of gaze during circular locomotion in light I. Compensatory head and eye nystagmus in the running monkey. J. Neurophvs. 67: 1146–1158.

    CAS  Google Scholar 

  • Stanford, M.R., Robbins, J., Kasp, E., and Dumonde, D.C. 1992. Passive administration of antibody against retinal S-antigen induces electroretinographic supernormality. Invest. Ophthal. Vis Sci. 33:30–35.

    PubMed  CAS  Google Scholar 

  • Steinberg, R.H., Frishman, L.J., and Sieving, P.A. 1991. Negative components of the electroretinogram from proximal retina and photoreceptor. Prog. in Retinal Res. 10: 121–160.

    Article  Google Scholar 

  • Steinberg, R.H., Linsenmeier, R.A., and Griff, E.R. 1983. Three light-evoked responses of the retinal pigment epithelium. Vis. Res. 23: 1315–1323.

    Article  PubMed  CAS  Google Scholar 

  • Steinberg, R.H., Linsenmeier, R.A., and Griff, E.R. 1985. Retinal pigment epithelial contributions to the electroretinogram and electrooculogram. Prog. in Retinal Research 4: 33–66.

    Article  Google Scholar 

  • Strain, G.M., Jackson, R.M., and Tedford, B.L. 1990. Visual evoked potentials in the clinically normal dog. J. Vet. Int. Med. 4: 222–225.

    Article  CAS  Google Scholar 

  • Tashiro, C., Muranishi, R., Gomyo, I., Mashimo, T., Tomi, K., and Yoshiya, I. 1986. Electroretinogram as a possible monitor of anesthetic depth. Graefe’s Arch. Clin. Exp. Ophthal. 224: 473–476.

    Article  CAS  Google Scholar 

  • Textorius, O., and Gottvall, E. 1992. The c-wave of the direct-current-recorded electroretinogram and the standing potential of the albino rabbit eye in response to repeated series of light stimuli of different intensities. Doc. Ophthal. 80: 91–103.

    Article  CAS  Google Scholar 

  • Thompson, D.A., and Drasdo, N. 1987. Computation of the luminance and pattern components of the bar pattern electroretinogram. Doc. Ophthal. 66: 233–244.

    Article  CAS  Google Scholar 

  • Tobimatsu, S., Celesia, G.G., Cone, S. and Gujrati, M. 1989. Electroretinograms to checkerboard pattern reversal in cats: physiological characteristics and effect of retrograde degeneration of ganglion cells. Electroenc. Clin. Neurophvs. 73: 341–352.

    Article  CAS  Google Scholar 

  • Vaegan, Arora, A., Crewther, S.G., and Millar, T.J. 1990. The effect of various anaesthetics on the spatial tuning of two major wave peaks in the transient pattern electroretinogram of the cat: evidence for pattern and luminance components. Vis. Res. 30: 1401–1407.

    Article  PubMed  CAS  Google Scholar 

  • Vaegan and Burne, J.A. 1987. Normal strobe electroretinograms without pattern electroretinograms in albino rats. Doc. Ophthal. 65: 113–124.

    Article  CAS  Google Scholar 

  • Wakabayashi, K., Geiser, J., and Sieving, P.A. 1988. Aspartate separation of the scotopic threshold response (STR) from the photoreceptor a-wave of the cat and monkey ERG. Inv. Ophthal. Vis. Sci. 29: 1615–1622.

    CAS  Google Scholar 

  • Wasserschaff, M. and Schmidt, J.G.H. 1986. Electroretinographic responses to the addition of nitrous oxide to halothane in rats. Doc. Ophthal. 64: 347–354.

    Article  CAS  Google Scholar 

  • Wioland, N., Rudolph, G., and Bonaventure, N. 1990. Electrooculographic and electroretinographic study in the chicken after dopamine and haloperidol. Doc. Ophthal. 75: 175–180.

    Article  CAS  Google Scholar 

  • Wioland, N., and Bonaventure, N. 1985. Photopic c-wave in the chicken ERG: sensitivity to sodium azide, epinephrine, sodium iodate, barbiturates, and other general anesthetics. Doc. Ophthal. 60: 407–412.

    Article  CAS  Google Scholar 

  • Velazquez-Moctezuma, J., Shalauta, M., Gillin, J.C., and Shiromani, P. 1991. Cholinergic antagonists and REM sleep generation. Brain Res. 543: 175–179.

    Article  PubMed  CAS  Google Scholar 

  • Yang, J., Xu, J., and Yang, S. 1990. [A simplified polygraphic method for studying sleep in the rat], Hua Hsi I Ko Ta Hsueh Hsueh Pao. 21: 394–397.

    PubMed  CAS  Google Scholar 

  • Yoshikawa, H., Yoshida, M., and Hara, I. 1990. Electroretinographic changes induced by organophosphorus pesticides in rats. J. Tox. Sci. 15: 87–95.

    Article  CAS  Google Scholar 

  • Xi, L., Smith, C.A., Saupe, K.W., Henderson, K.S., and Dempsey, J.A. 1993. Effects of rapid-eye-movement sleep on the apneic threshold in dogs. J. Appl. Phvsiol. 75: 1129–1139.

    CAS  Google Scholar 

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Geller, A.M., Osborne, C.M., Peiffer, R.L. (1995). The ERG, EOG, and VEP in Rats. In: Weisse, I., Hockwin, O., Green, K., Tripathi, R.C. (eds) Ocular Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1887-7_2

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