Abstract
Ocular toxicity and systemic adverse effects of 0.3% ofloxacin ophthalmic solution (0.3%OFLX) which was administered 3 times daily for one year were studied in dogs.
In general conditions, food intake, behavior and body weights, no significant difference was observed between the non treated group and 0.3%OFLX treated group throughout the experimental period. Signs for ocular toxicity such as anterior ocular irritation, abnormality of cornea and lens opacity, as well as fundus abnormality were no observed during ophthalmological examination in either group. Electroretinogram showed no abnormality by administration of 0.3%OFLX. Hematological examinations and blood chemistry resulted in normal values in any test item. Autopsy, organ weight, histopathology of ocular tissues and systemic organs showed no change due to ofloxacin.
It is concluded from these results that one year application of 0.3%OFLX ophthalmic solution to dogs causes neither ocular toxicity nor systemic adverse effect.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. T. Smith, 1991, Ofloxacin, a bactericidal antibacterial, Chemotherapy ,37:2.
K. Sato, 1982, In vitro and in vivo activity of DL-8280, a new oxazine derivative, Antimicrobial Agents and Chemotherapy ,22:548.
K. Sato, M. Inoue and S. Mitsuhashi, 1984, In vitro and in vivo antibacterial activity of DL-8280, Chemotherapy ,32:1.
M. Tsumura, K. Sato, T. Une and H. Tachizawa, 1984, Metabolic disposition of DL-8280 the first report: Comparison between absorption and excretion of DL-8280 in the dog and monkey by bioassay and HPLC methods, Chemotherapy ,32:1179.
M. Fukuda and K. Sasaki, 1986, Penetration of administered ofloxacin into ocular tissues, Foil. Ophthalmol Jpn. ,37:823.
Y. Mitsui, S. Sakuragi, O. Tamura, M. Abe, I. Watanabe, M. Ueno, K. Choshi, H.Sakata, T. Suehiro, N. Ohoba, S. Fujita, Y. Miyazono, K. Sasaki, T. Yamamura, N. Watanabe, M. Uyama, K. Kanai, T. Tokuyama, H. Miyatani, M. Itoi, Y. Kodama, H. Tasaka, R. Manabe, Y. Ohashi, Y. Shimomura, K. Segawa, K. Nishiyama, K. Norose, S. Inoue, K. Matsumura, M. Ooishi, F. Sakaue, A. Oomomo, J. Hara, S. Harino, J. Tsutsui, H. Kimura, S. Inoue, M. Higashitsutsumi, M. Sakamoto, T. Miwatani and T. Onoda, 1986, Effect of ofloxacin ophthalmic solution in the treatment of external bacterial infections of the eye, Foil. Ophthalmol. Jpn. ,37:1115.
M. Fukuda and K. Sasaki, 1988, The influence of melanin on intraocular dynamics,Acta. Soc. Ophthalmol. Jpn. ,92:1839.
H. Kojima, M. Hirohashi, T. Sakurai, Y. Kasai and A. Akashi, 1984, General pharmacology of DL-8280, Chemotherapy ,32:1147.
H. Yamauchi, H. Mibu, M. Sasano, M. Hayashi, K. Takase, S. Nagamori, T.Terashima, A. Okahara, H. Kito, N. Ueno and T. Iso, 1985, Safety evaluation of ofloxacin in rabbits II. Ocular irritation test and systemic influences with topical application for four weeks, Foil. Ophthalmol. Jpn. ,36:2302.
H. Ohno, F. Inage, K. Akahane, K. Aihara, M. Yoshida and T. Onodera, 1984, Acute toxicity of a synthetic antimicrobial, DL-8280, in mice, rats and monkeys, Chemotheraphy 32:1084.
Y. Kikkawa, 1972, Normal corneal staining with fluorescein. Exp. Eye Res. 14:13.
T. E. Hickey, G. L. Beck and J. A. Jr. Botta, 1973, Optimum fluorescein staining time in ocular irritation studies. Tox. Appl. Pharmacol. ,26:571.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Sawa, K., Hikida, M., Mibu, H., Shirasawa, E., Takase, K., Suda, H. (1995). One-Year Ocular Toxicity Study of Ofloxacin Ophthalmic Solution in Beagle Dogs. In: Weisse, I., Hockwin, O., Green, K., Tripathi, R.C. (eds) Ocular Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1887-7_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1887-7_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5769-8
Online ISBN: 978-1-4615-1887-7
eBook Packages: Springer Book Archive