Skip to main content
SpringerLink
Log in

Continuous Flow Contact Lenses Delivery of Diclofenac to Rabbit Cornea and Aqueous Humor

  • Chapter
Book cover Ocular Toxicology

  • 146 Accesses

Abstract

Although satisfactory therapeutic results are obtained with usual topical ophthalmic drug (topical ocular solutions and ointments) they present some inconveniences: 1st. Bioavailability is poor, requiring high doses and repeated applications. 2nd. Diffusion of the drug into the bloodstream across de nasal mucosa which is continuous with the conjuntival sac, represents an additional risk of systemic toxicity. (Chang and Lee, 1987, Salminen,1990).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agata, M.,Abe, T and Kon, M.,1983. Effect of topical diclofenac sodium, a non steroidal anti-inflamatory drug onvarious ocular inflammatory models in animals. Acta. Soc. Ophthalmol. Jap. 87:19.

    CAS  Google Scholar 

  • Brettschneider, L., Prauss, R., Kreja, L. and Havranek, M.,1975. Intraocular penetration of bacitracin and polimyxin B after administration by means of hydrophilic gel contact lenses. Ophthalmol Res. 7: 296.

    Article  CAS  Google Scholar 

  • Busin, M and Spitznas, M.,1988. Sustained gentamicin release by presoaked medicated bandage contact lenses. Ophthalmology 95: 796.

    PubMed  CAS  Google Scholar 

  • Chang, S.C. and Lee, V.H.L.,1987. Nasal and conjuntival contribution to the systemic absorption of topical timolol in the oigmented rabbit: implications in the design of strategies to maximize the ratio of ocular to systemic absorption. J. Ocular Pharmacol. 3:159.

    Article  CAS  Google Scholar 

  • Friedman, Z, Allen, R.C. and Ralph, S.M.,1985. Topical acetazolamide and methazolamide delivered by contact lenses. Arch. Ophthalmol. 103: 963.

    Article  PubMed  CAS  Google Scholar 

  • Hillman, J.S.,1974. Managementof acute glaucome with pilocarpine spaked hydrophilic lens. Br. J. Ophthalmol. 58: 674.

    Article  PubMed  CAS  Google Scholar 

  • Hillman, J.S. Marsters, J.B. and Broad, A.,1975. Pilocarpine delivery by hydrophilic lens in management of acute glaucoma. Trans. Ophthalmol. Soc. UK 95:79.

    PubMed  CAS  Google Scholar 

  • Hull, D.S. Edelhauser, H.F. and Hyndiuk, R.A.,1974. Ocular penetration of prednisolone and the hydrophilic lens. Arch. Ophthalmol. 92:413.

    Article  PubMed  CAS  Google Scholar 

  • Iwasaki, W., Kosaka, Y., Momose, T. and Yasuda, Y.,1988. Absorption of topical Disodium Cromoglicate and its preservatives by soft contact lenses. CLAO J. 14/3:155.

    PubMed  CAS  Google Scholar 

  • Jain, M.R. and Lal, S., 1983. Intraocular penetration of carbenicillin, gentamicin and chloramphenicol with Sauflon 85 soft contact lenses. Ind. J. Ophthalmol. 31: 645.

    CAS  Google Scholar 

  • Krohn, D.L. and Breitfeiler, J.M.,1975. Quantification of pilocarpine flux across isolated rabbit cornea by hydrogel polimer lenses. Invest. Ophthalmol. Vis. Sci. 14: 152.

    CAS  Google Scholar 

  • McCarey, B.E., Schmidt, F.M., Wilkinson, K.D. and Baum, J.P.,1984. Gentamicin diffusion across hydrogel bandage lenses and its kinetic distribution on the eye. Curr. Eye Res. 5:977.

    Article  Google Scholar 

  • Podos, S.M., Becker, B., Asseff, C. and Hartstein,J.,1972. Pilocarpine therapy with soft contact lenses. Am. J. Ophthalmol 73:336.

    PubMed  CAS  Google Scholar 

  • Praus, R., Brettscheider, L., Kreja, L. and Kalvadora, D., 1972. Hydrophilic contact lenses as a new therapeutic approach for topical use of chloramphenicol and tetracycline. Ophthalmologica 165:62.

    Article  PubMed  CAS  Google Scholar 

  • Report B ,1983. Diclofenac-Na: Distribution in the rabbit eye. Pharma Research and Development Pharmacological Chemistry. Ciba-Geigy limited. Basle. 1983.

    Google Scholar 

  • Robinson, J.R. and Eriksen, S.P., 1978. Drug delivery from soft contact lens materials. In: “Soft Contact Lenses: Clinical Applied Technology.” M. Ruben,ed. London Balliere-Tindall. pp. 265–280.

    Google Scholar 

  • Rubin, M. and Watkins, R.,1975. Pilocarpine for the soft hydrophilic contact lens. Brit. J. Ophthalmol. 59: 455.

    Article  Google Scholar 

  • Salminen, L. Review:, 1990. Systemic absorption of topically applied ocular drugs in humans. J. Ocular Pharmacol. 6:243.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Therapeutics and Ophthalmology, School of Medicine, Universtiy of Alicante, Alicante, Spain

    V. Montoya

  2. Departments of Pharmacology, School of Medicine, Universtiy of Alicante, Alicante, Spain

    M. A. Company & A. Orts

Authors
  1. V. Montoya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Company
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Palmero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Orts
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Boehringer Ingelheim KG, Ingelheim, Germany

    Ingo Weisse

  2. University of Bonn, Bonn, Germany

    Otto Hockwin

  3. Medical College of Georgia, Augusta, Georgia, USA

    Keith Green

  4. South Carolina Eye Institute, Columbia, South Carolina, USA

    Ramesh C. Tripathi

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Montoya, V., Company, M.A., Palmero, M., Orts, A. (1995). Continuous Flow Contact Lenses Delivery of Diclofenac to Rabbit Cornea and Aqueous Humor. In: Weisse, I., Hockwin, O., Green, K., Tripathi, R.C. (eds) Ocular Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1887-7_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1887-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5769-8

  • Online ISBN: 978-1-4615-1887-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation