Ocular Pharmacokinetics of Some Proteolytic Drugs in the Course of Topical Application: Long Term Observation

  • G. S. Polunin
  • M. N. Ivanov
  • A. A. Fedorov
  • A. N. Ovchinnikov


We have made a comparative study of the effects which occurred when some proteolytic enzymes of animal, vegetable and microbial origin and kallikreintrypsin inhibitors were applied to either unchanged or impaired ocular tissues and fluids. The analysis was based on the experimental data and on clinical research.

This comparative study was instrumental in defining the following main lines of approach to enzymotherapy:
  • selection of an enzyme in line with its specific form of action and the specific features of a pathological formation;

  • definition of optimum therapeutic dosage forms;

  • selection of a method of attack on pathological formation;

  • creation of favorable condition for prolonging the duration of action of an enzyme drug in an impaired tissue.

We have worked out some new ways of employing known enzymes and indications for using these enzymes in the complex treatment of a variety of diseases and disorders, including vitreous hemorrhages and uveitis of various etiology, microsurgical and laser treatment of glaucoma, cataract extraction and non-surgical treatment of chalazion, scar of eyelids and obstruction of nasolacrimal ducts.


Proteolytic Enzyme Vitreous Hemorrhage Ocular Tissue Isotonic Solution Nasolacrimal Duct 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • G. S. Polunin
    • 1
  • M. N. Ivanov
    • 1
  • A. A. Fedorov
    • 1
  • A. N. Ovchinnikov
    • 1
  1. 1.Research Institute of Eye DiseasesRussian Academy of Medical ScienceMoscowRussia

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