Abstract
In plants and animals carbohydrate/protein interactions are fundamental to biological function. This form of biomolecular recognition usually involves binding of a carbohydrate ligand to a lectin receptor [1]. One of the well known and thoroughly studied lectin systems in mammals is the asialoglycoprotein receptor (ASGP-R) found on hepatocytes [2–5]. This receptor binds ligands with terminal galactose or N-acetylgalactosamine and routes these to lysosomes before recycling to the cell surface [6]. The natural ligands for the ASGP-R are believed to be serum glycoproteins which lose their terminal sialic acid during circulation exposing clusters of subterminal galactose residues on their N-linked oligosaccharides. Thereby, the ASGP-R is believed to be primarily involved in maintaining the serum concentration of structurally diverse glycoproteins.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lee, Y.C. (1989) Ciba Found. Symp., 145, 80–95 (Wiley, Chichester, UK).
Van Lenten, L., and Ashwell, G., (1972) J. Biol. Chem. 247, 4633–4640.
Hudgin, R.L., Pricer, W.E. Jr., Ashwell, G., Stockert, R.J., and Morell, A.G., (1974) J. Biol. Chem. 249, 5536–5543.
Ashwell, G., and Morell, A.G. (1974) Adv. Enzymol. Relat. Areas Mol. Biol. 41, 99–128.
Ashwell, G., and Harford, J. (1982) Annu. Rev. Biochem. 51, 531–554.
Spiess, M., (1990) Biochemistry, 29, 10009–10018.
Drickamer, K., (1988) J. Biol. Chem. 263, 9557–9560.
Rice, K.G., Weisz, O.A., Barthel, T., Lee, R.T., and Lee, Y.C., (1990) J. Biol. Chem. 265, 18429–18434.
Drickamer, K. (1993) Curr. Opin. Struc. Biol. 3, 393–400.
Chiu, M.H., Tamura, T., Wadhwa, M.S., and Rice, K.G. (1994) J. Biol. Chem., 269, 16195–16202.
Tamura, T., Wadhwa, M.S., and Rice, K.G. (1994) Anal. Biochem., 216, 335–344.
Tamura, T., Wadhwa, M.S., Ming, M.H. Chiu, M.L. Corradi Da Silva, Tamara McBroom, and Rice, K.G. (1994) Methods in Enzymology, Academic Press (Y.C. Lee, Ed.) 247, 43–55.
Greenwood, F.C., Hunter, W.M., and Glover, J.S. (1963) Biochem. J. 89, 114–123.
Lee, Y.C., Townsend, R.R., Hardy, M.R., Lonngren, J., Arnarp, J., Haraldsson, M., and Lonn, H. (1983) J. Biol. Chem. 258, 199–202.
Townsend, R.R., Hardy, M.R., Wong, T.C., and Lee, Y.C., (1986) Biochemistry, 25, 5716–5725.
Lee, R.T., and Lee, Y.C. (1987) Glycoconjugate J. 4, 317–328.
Baenziger, J.U. and Fiete, D., (1980) Cell, 22, 611–620.
Lee, R.T., Rice, K.G., Rao, N.D.N., Ichikawa, Y., Barthel, T., Piskarev, V., and Lee, Y.C., (1989) Biochemistry 28, 8351–8357.
Lehrman, M. A., Pizzo, V., Imber M. J. and Hill R.L. (1986) J. Biol. Chem. 261, 7412–7418.
Lehrman, M., and Hill, R. L., (1986) J. Biol. Chem. 261, 7419–7425.
Lehrman, M., Haltiwanger R.S., and Hill R.L. (1986) J. Biol. Chem. 261, 7426–7432.
Haltiwanger R.S., Lehrman, M.A. Eckhardt, A.E. and Hill, R.L. (1986) J. Biol. Chem. 261, 7433–7439.
Haltiwanger R.S., and Hill, R.L. (1986) J. Biol. Chem. 261, 7440–7444.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Rice, K.G., Chiu, M.H., Wadhwa, M.S., Thomas, V.H., Stubbs, H.J. (1995). In Vivo Targeting Function of N-Linked Oligosaccharides. In: Alavi, A., Axford, J.S. (eds) Glycoimmunology. Advances in Experimental Medicine and Biology, vol 376. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1885-3_30
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1885-3_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5768-1
Online ISBN: 978-1-4615-1885-3
eBook Packages: Springer Book Archive