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Significance and Molecular Basis for IgG Glycosylation Changes in Rheumatoid Arthritis

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Book cover Glycoimmunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 376))

Abstract

Genetic and environmental factors are thought to contribute to either the initial susceptibility to synovitis or persistence of joint disease in patients with rheumatoid arthritis. The genetic component of the disease probably accounts for no more than 12–15% of the whole, only one-third to one-half of this component can be accounted for by genes encoded within the HLA complex which may influence disease severity rather than susceptibility (1). At present the recognition of specific HLA markers for more aggressive forms of the disease has not yet been translated into any form of successful therapy. Further, therapies aimed at CD4+ T-cells have not been successful, as also predicted from lack of amelioration of arthritis in AIDS patients. Clearly other risk factors need to be established in order for new therapeutic strategies to be developed.

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Author information

Authors and Affiliations

  1. Molecular Medicine Unit, Dept. of Molecular Pathology, University College London Medical School, Windeyer Building, 46 Cleveland Street, London, W1P 6DB, UK

    T. W. Rademacher, R. H. V. Jones & P. J. Williams

Authors
  1. T. W. Rademacher
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  2. R. H. V. Jones
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  3. P. J. Williams
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Editor information

Editors and Affiliations

  1. St. George’s Hospital Medical School, University of London, London, England

    Azita Alavi  & John S. Axford  & 

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© 1995 Springer Science+Business Media New York

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Rademacher, T.W., Jones, R.H.V., Williams, P.J. (1995). Significance and Molecular Basis for IgG Glycosylation Changes in Rheumatoid Arthritis. In: Alavi, A., Axford, J.S. (eds) Glycoimmunology. Advances in Experimental Medicine and Biology, vol 376. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1885-3_20

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  • DOI: https://doi.org/10.1007/978-1-4615-1885-3_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5768-1

  • Online ISBN: 978-1-4615-1885-3

  • eBook Packages: Springer Book Archive

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