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Colony Stimulating Factor-1 in the Female Reproductive Tract During the Pre- and Peri-Implantation Periods

  • Chapter
Endocrinology of Embryo-Endometrium Interactions

Part of the book series: Reproductive Biology ((RBIO))

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Abstract

Viviparous reproduction in mammals demands co-ordination between maternal physiology and embryonic development. This includes the synchronization between pre-implantation embryonic development and the uterine preparation for implantation, the coordinated development of maternal and fetal cells during the formation of the placenta, the requirements of parturition and the development of the mammary gland in preparation for lactation. Paradoxically, in mice, the uterine preparation for implantation, pre-implantation embryonic development and decidualization can proceed independently of one another. Thus, fertilized oocytes can be cultured to the blastocyst-stage in defined medium, whereafter they can be sucessfully transferred to pseudopregnant recipients to complete embryonic development. Similarly, non-pregnant ovariectomized mice can be made pseudopregnant by administration of the appropriate regimens of steroid hormones and to be induced to undergo decidualization by an inert stimulus such as arachis oil applied into the uterine lumen in the absence of an embryo. However, embryonic development in vitro is slower than observed in vivo and such development is restricted to a few inbred mouse strains. In addition, in rodents it is essential to maintain synchrony between pre-implantation embryonic development and the uterine preparation for pregnancy in vivo so that the embryo is ready to implant during the relatively small window of uterine receptivity (Brinster, 1963; Finn, 1980; Finn and Martin, 1972; Harlow and Quinn, 1982).

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References

  • Athanassakis, I., Bleackley, C., Paetkau, V., Guilbert, L., Barr, P.J. and Wegmann, T.G., The immunostimulatory effect of T cells and T-cell lymphokines on murine fetally derived placental cells, J. Immunol. 138:37–44(1987).

    PubMed  CAS  Google Scholar 

  • Arceci, R.J., Shanahan, F., Stanley, E.R. and Pollard, J.W., Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development, Proc. Natl. Acad. Sci. USA 86:8818–8822(1989).

    Article  PubMed  CAS  Google Scholar 

  • Arceci, R.J., Pampfer, S. and Pollard, J.W., Expression patterns of CSF-1/c-fms and SF/c-kit mRNA during early pre-implantation mouse development, Dev. Biol. 151:1–8(1992a).

    Article  PubMed  CAS  Google Scholar 

  • Arceci, R.J., Pampfer, S. and Pollard, J.W., Role and expression of colony-stimulating factor-1 and steel factor receptors and their ligands during pregnancy in the mouse, Reprod. Fertil. Dev. 4:619–632(1992b).

    Article  CAS  Google Scholar 

  • Armstrong, D.T. and Chaouat, G., Effects of lymphokines and immune complexes on murine placental cell growth in vitro, Biol. Reprod. 40:466–474(1989).

    Article  PubMed  CAS  Google Scholar 

  • Bartocci, A., Pollard, J.W. and Stanley, E.R., Regulation of colony-stimulating factor 1 during pregnancy, J. Exp. Med. 164:956–961(1986).

    Article  PubMed  CAS  Google Scholar 

  • Boocock, C.A., Jones, G.E., Stanley, E.R. and Pollard, J.W., Colony stimulating factor-1 induces rapid behavioral responses in the mouse macrophage cell-line, BAC1:2F5, J. Cell Sci. 93:447–456(1989).

    PubMed  CAS  Google Scholar 

  • Boulay, J-L. and Paul, W.E., The interleukin-4-related lymphokines and their binding to hematopoietin receptors, J. Biol. Chem. 267:20525–20528(1992).

    PubMed  CAS  Google Scholar 

  • Bradley, T.R., Stanley, E.R. and Sumner, M.A., Factors from mouse tissues stimulating colony growth of mouse bone marrow cells in vitro, Aust. J. Exp. Biol. Med. Sci. 49:595–603(1971).

    Article  PubMed  CAS  Google Scholar 

  • Brigstock, D.R., Growth factors in the uterus: steroidal regulation and biological actions, in: Bailliere’s Clinical Endocrinology and Metabolism, Bailliere Tindall, (1991), pp. 791-808.

    Google Scholar 

  • Brinster, R.L., A method for in vitro cultivation of mouse ova from two-cell to blastocyst, Exp. Cell Res. 32:205–208(1963).

    Article  PubMed  CAS  Google Scholar 

  • Chen, H-L., Yang, Y., Hu, X-L., Yelavarthi, K.K., Fishback, J.L. and Hunt, J.S., Tumor necrosis factor-alpha mRNA and protein are present in human placental and uterine cells at early and late stages of gestation, Am. J. Pathol. 139:327–335(1991).

    PubMed  CAS  Google Scholar 

  • Clarke, C.L. and Sutherland, R.L., Progestin regulation of cellular proliferation, Endocrine Reviews 11:266–301(1990).

    Article  PubMed  CAS  Google Scholar 

  • Crainie, M., Guilbert, L.J. and Wegmann, T., Expression of novel cytokine transcripts in murine placenta, Biol. Reprod. 43:999–1005(1990).

    Article  PubMed  CAS  Google Scholar 

  • Daiter, E., Pampfer, S., Yeung, Y.G., Barad, D., Stanley, E.R. and Pollard, J.W., Expression of colony stimulating factor-1 in the human uterus and placenta, J. Clin. Endocr. Metab. 74:850–858(1992).

    Article  PubMed  CAS  Google Scholar 

  • Das, R.M. and Martin, L., Uterine DNA synthesis and cell proliferation during early decidualization induced by oil in mice, J. Reprod. Fert. 53:125–128(1978).

    Article  CAS  Google Scholar 

  • De, M., Choudhuri, R. and Wood, G.W., Determination of the number and distribution of macrophages, lymphocytes, and granulocytes in the mouse uterus from mating through implantation, J. Leuk. Biol 50:252–262(1991).

    CAS  Google Scholar 

  • De, M. and Wood, G.W., Analysis of the number and distribution of macrophages, lymphocytes, and granulocytes in the mouse uterus from implantation through parturition, J. Leuk. Biol 50:381–392(1991).

    CAS  Google Scholar 

  • De, M., Sanford, T.R. and Wood, G.W., Interleukin-1, interleukin-6, and tumor necrosis factor α are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone, Dev. Biol. 151:297–305(1992).

    Article  PubMed  CAS  Google Scholar 

  • De, M., Sanford, T. and Wood, G.W., Relationship between macrophage colony-stimulating factor production by uterine epithelial cells and accumulation and distribution of macrophages in the uterus of pregnant mice, J. Leuk. Biol. 53:240–248(1993).

    CAS  Google Scholar 

  • Finn, C.A., The endometrium during implantation, in: The endometrium, F.A. Kimball, ed., Spectrum Publications, Inc., London (1980), pp. 43–53.

    Chapter  Google Scholar 

  • Finn, C.A. and Martin, L., Endocrine control of the timing of endometerial sensitivity to a decidual stimulus, Biol. Reprod. 7:82–86(1972).

    PubMed  CAS  Google Scholar 

  • Haimovici, F. and Anderson, D.J., Effects of growth factors and growth factor-extracellular matrix interactions on mouse trophoblast outgrowth in vitro, Biol. Reprod. 49:124–130(1993).

    Article  PubMed  CAS  Google Scholar 

  • Harlow, G.M. and Quinn, P., Development of preimplantation mouse embryos in vivo and in vitro, Aust. J. Biol. Sci. 35:187–193(1982).

    PubMed  CAS  Google Scholar 

  • Haskill, S., Johnson, C., Eierman, D., Becker, S. and Warren, K., Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes, J. Immunol. 140:1690–1694(1988).

    PubMed  CAS  Google Scholar 

  • Hill, J.A., Haimovici, F. and Anderson, D.J., Products of activated lymphocytes and macrophages inhibit mouse embryo development in vitro, J. Immunol. 139:2250–2259(1987).

    PubMed  CAS  Google Scholar 

  • Hunt, J.S. and Pollard, J.W., Macrophages in the uterus and placenta, Curr. Prog. Microbiol. Immunol. 181:39–63(1992).

    Article  CAS  Google Scholar 

  • Hunt, J.S., Endocrine regulation of tumor necrosis factor-α, Reprod. Fertil. Dev. (1993). (In Press)

    Google Scholar 

  • Hunt, J.S., Chen, H-L., Hu, X.L. and Pollard, J.W., Normal distribution of tumor necrosis factor-α messenger ribonucleic acid and protein in the uteri, placentas and embryos of osteopetrotic (op/op) mice lacking colony stimulating factor-1, Biol. Reprod. (1993). (In Press)

    Google Scholar 

  • Jokhi, P.P., Chumbly, G., King, A., Gardner, L. and Loke, Y.W., Expression of the colony stimulating factor-1 receptor (c-fms product) by cells at the human uteroplacental interface, Laboratory Investigation 68:308–320(1993).

    PubMed  CAS  Google Scholar 

  • Kanzaki, H., Crainie, M, Lin, H., Yui, J., Guilbert, L.J., Mori, T. and Wegmann, T.G., The in situ expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA at the maternal-fetal interface, Growth Factors 5:69–74(1991).

    Article  PubMed  CAS  Google Scholar 

  • Kauma, S.W., Aukerman, S.L., Eierman, D. and Turner, T., Colony-stimulating factor-1 and c-fms expression in human endometrial tissues and placenta during the menstrual cycle and early pregnancy, J. Clin. Endocr. Metab. 73:746–751(1991).

    Article  PubMed  CAS  Google Scholar 

  • Kawasaki, E.S. and Ladner, M.B., Molecular biology of macrophage colony stimulating factor, in: Colony Stimulating factors: Molecular and Cellular Biology, T.M. Dexter, J.M. Garland and N.G. Testa, eds., Marcel Dekker, Inc., New York (1990), pp. 155–176.

    Google Scholar 

  • Li, Y., Matsuzaki, N., Masuhiro, K., Kameda, T., Taniguchi, T., Saji, F., Yone, K. and Tanizawa, O., Trophoblast-derived tumor necrosis factor-α induces release of human chorionic gonadotrophin using interleukin-6 (IL-6) and IL-6-receptor-dependent system in the normal human trophoblasts, J. Clin. Endocr. Metab. 74:184–191(1992).

    Article  PubMed  CAS  Google Scholar 

  • Loke, Y.W., King, A., Gardner, L. and Carter, N.P., Evidence for the expression of granulocyte-macrophage colony-stimulating factor receptors by human first trimester extravillous trophoblast and its response to this cytokine, J. Reprod. Immunol. 22:33–45(1992).

    Article  PubMed  CAS  Google Scholar 

  • Luetteke, N.C., Qiu, T.H., Peiffer, R.L., Oliver, P., Smithies, O. and Lee, D.C., TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice, Cell 73:263–278(1993).

    Article  PubMed  CAS  Google Scholar 

  • Martin, L. and Finn, C.A., Hormone secretion during early pregnancy in the mouse, J. Endocr. 45:57–65(1969).

    Article  PubMed  Google Scholar 

  • Martin, L. and Finn, C.A., Oestrogen-gestagen interactions on mitosis in target tissues, in: Basic Actions of Sex Steroids on Target Organs, S. Karger, Basel, Switzerland (1971), pp. 172–188.

    Google Scholar 

  • Metcalf, D., Control of granulocytes and macrophages: molecular, cellular and clinical aspects, Science 254:529–533(1991).

    Article  PubMed  CAS  Google Scholar 

  • Pampfer, S., Arceci, R.J. and Pollard, J.W., Role of colony stimulating factor-1 (CSF-1) and other lympho-hematopoietic growth factors in mouse preimplantation development, BioEssays 13:535–540(1991a).

    Article  PubMed  CAS  Google Scholar 

  • Pampfer, S., Tabibzadeh, S., Chuan, F.C. and Pollard, J.W., Expression of colony stimulating factor-1 (CSF-1) mRNA in human endometrial glands during the menstrual cycle: Molecular cloning of a novel transcript that predicts a cell surface form of CSF-1, Mol Endo. 5:1931–1938(1991b).

    Article  CAS  Google Scholar 

  • Pampfer, S., Daiter, E., Barad, D. and Pollard, J.W., Expression of the colony-stimulating factor-1 receptor (c-fms proto-oncogene product) in the human uterus and placenta, Biol. Reprod. 46:48–57(1992).

    Article  PubMed  CAS  Google Scholar 

  • Pollard, J.W., Bartocci, A., Arceci, R., Orlofsky, A., Ladner, M.B. and Stanley, E.R., Apparent role of the macrophage growth factor, CSF-1, in placental development, Nature 330:484–486(1987).

    Article  PubMed  CAS  Google Scholar 

  • Pollard, J.W., Regulation of polypeptide growth factor synthesis and growth factor-related gene expression in the rat and mouse uterus before and after implantation, J. Reprod. Fert. 88:721–731(1990).

    Article  CAS  Google Scholar 

  • Pollard, J.W., Lymphohematopoietic cytokines in the female reproductive tract, Current Opinion in Immunology 3:772–777(1991).

    Article  PubMed  CAS  Google Scholar 

  • Pollard, J.W., Hunt, J.W., Wiktor-Jedrzejczak, W. and Stanley, E.R., A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility, Dev. Biol. 148:273–283(1991a).

    Article  PubMed  CAS  Google Scholar 

  • Pollard, J.W., Pampfer, S. and Arceci, R.J., Class III tyrosine kinase receptors at the maternal-fetal interface, in: Cellular and Molecular Biology of the Materno-Fetal Relationship, G. Chauoat and J. Mowbray, eds., INSERM/John Libbey Eurotext Ltd., (1991b), pp. 81-89.

    Google Scholar 

  • Price, L.K.H., Choi, H.U., Rosenberg, L. and Stanley, E.R., The predominant form of secreted colony stimulating factor-1 is a proteoglycan, J. Biol. Chem. 267:2190–2199(1992).

    PubMed  CAS  Google Scholar 

  • Regenstreif, L.J. and Rossant, J., Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis, Dev. Biol. 133:284–294(1989).

    Article  PubMed  CAS  Google Scholar 

  • Rettenmier, C.W. and Roussel, M.F., Biosynthesis of macrophage colony-stimulating factor (CSF-1): Differential processing of CSF-1 precursors suggests alternative mechanisms for stimulating CSF-1 receptors, Mol. Cell. Biol. 8:5026–5034(1988).

    PubMed  CAS  Google Scholar 

  • Robertson, S.A., Lavranos, T.C. and Seamark, R.F., In vitro models of the maternal-fetal interface, in: The Molecular and Cellular Immunobiology of the Maternal-Fetal Interface, T.G. Wegmann, E. Nisbet-Brown and T.J. Gill III, eds., Oxford University Press, New York (1990), pp. 191–206.

    Google Scholar 

  • Robertson, S.A. and Seamark, R.F., Granulocyte macrophage colony stimulating factor (GM-CSF) in the murine reproductive tract: stimulation by seminal factors, Reprod. Fertil. Dev. 2:359–368(1990).

    Article  PubMed  CAS  Google Scholar 

  • Robertson, S.A., Mayrhofer, G. and Seamark, R.F., Uterine epithelial cells synthesize granulocyte-macrophage colony-stimulating factor and inter-leukin-6 in pregnant and nonpregnant mice, Biol. Reprod. 46:1069–1079(1992).

    Article  PubMed  CAS  Google Scholar 

  • Rosendaal, M., Colony-stimulating factor (CSF) in the uterus of the pregnant mouse, J. Cell Sci. 19:411–423(1975).

    PubMed  CAS  Google Scholar 

  • Roth, P. and Stanley, E.R., The biology of CSF-1 and its receptor, Curr. Topics Microbiol. Immunol. 181:141–147(1992).

    Article  CAS  Google Scholar 

  • Saito, S., Saito, M., Motoyoshi, K. and Ichijo, M., Enhanced effects of human macrophage colony-stimulating factor on the secretion of human chorionic gonadotrophin by human chorionic villous cells and tPA30-l cells, Biochem. Biophys. Res. Comm. 178:1099–1104(1991).

    Article  PubMed  CAS  Google Scholar 

  • Sanford, T.R., De, M. and Wood, G.W., Expression of colony-stimulating factors and inflammatory cytokines in the uterus of CD1 mice during days 1 to 3 of pregnancy, J. Reprod. Fert. 94:213–220(1992).

    Article  CAS  Google Scholar 

  • Scheffler, J.E., Fleissner, L.C., Seelig, G.F., Nagabhushan, T.L. and Trotta, P.P., Characterization of the human granulocyte-macrophage colony-stimulating factor receptor from placenta, in: Hematopoiesis, Alan R. Liss, Inc., NY (1990), pp. 107–115.

    Google Scholar 

  • Sherr, C.J., Colony stimulating factor-1 receptor, Blood 75:1–12(1990).

    PubMed  CAS  Google Scholar 

  • Sherr, C.J. and Stanley, E.R., Colony-stimulating factor 1/macrophage colony-stimulating-factor, in: Handbook of Experimental Pharmacology: Peptide Growth Factors and their Receptors, M.B. Sporn and A.B. Roberts, eds., Springer-Verlag, Heidelberg, New York (1990), pp. 667–698.

    Chapter  Google Scholar 

  • Sherr, C.J., Mitogenic response to colony-stimulating factor 1, Trends Genet. 7:398–402(1991).

    PubMed  CAS  Google Scholar 

  • Stewart, C.L., Kaspar, P., Brunet, L.J., Bhatt, H., Gadi, I., Königen, F. and Abbondanzo, S.J., Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor, Nature 359:76–79(1992).

    Article  PubMed  CAS  Google Scholar 

  • Tabibzadeh, S., Ubiquitous expression of TNF-α/cachectin immunoreactivity in human endometrium, Am. J. Rep. Immunol. 26:1–4(1991a).

    CAS  Google Scholar 

  • Tabibzadeh, S., Human endometrium: An active site of cytokine production and action, Endocrine Reviews 12:272–290(1991b).

    Article  PubMed  CAS  Google Scholar 

  • Tachi, C. and Tachi, S., Role of macrophages in the maternal recognition of pregnancy, J. Reprod. Fert. 37:63–68(1989).

    CAS  Google Scholar 

  • Tartakovsky, B., Goldstein, O. and Brosh, N., Colony-stimulating factor-1 blocks early pregnancy in mice, Biol. Reprod. 44:906–912(1991).

    Article  PubMed  CAS  Google Scholar 

  • Vassalli, P., The pathophysiology of tumor necrosis factors, Ann. Rev. Immunol. 10:411–452(1992).

    Article  CAS  Google Scholar 

  • Visvader, J. and Verma, I.M., Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes, Mol. Cell. Biol. 9:1336–1341(1989).

    PubMed  CAS  Google Scholar 

  • Welsh, A.O. and Enders, A.C., Chorioallantoic placenta formation in the rat. III. Granulated cells invade the uterine luminal epithelium at the time of epithelial cell death, Biol. Reprod. 49:38–57(1993).

    Article  PubMed  CAS  Google Scholar 

  • Wiktor-Jedrzejczak, W., Bartocci, A., Ferrante, A.W., Jr., Ahmed-Ansari, A., Sell, K.W., Pollard, J.W. and Stanley, E.R., Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse, Proc. Natl. Acad. Sci. USA 87:4828–4832(1990).

    Article  PubMed  CAS  Google Scholar 

  • Wiktor-Jedrzejczak, W., Urbanowska, E., Aukerman, S.L., Pollard, J.W., Stanley, E.R., Ralph, P., Ansari, A.A., Sell, K.W. and Szperl, M., Correction by CSF-1 of defects in the osteopetrotic op/op mouse suggests local, developmental, and humoral requirements for this growth factor, Exp. Hematol. 19:1049–1054(1991).

    PubMed  CAS  Google Scholar 

  • Wood, G.W., De, M., Sanford, T. and Choudhuri, R., Macrophage colony stimulating factor controls macrophage recruitment to the cycling mouse uterus, Dev. Biol. 152:336–343(1992).

    Article  PubMed  CAS  Google Scholar 

  • Yelavarthi, K.K., Chen, H-L., Yang, Y., Cowley Jr., B.D., Fishback, J.L. and Hunt, J.S., Tumor necrosis factor-α mRNA and protein in rat uterine and placental cells, J. Immunol. 146:3840–3848(1991).

    PubMed  CAS  Google Scholar 

  • Yoshida, H., Hayashi, S.I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L.D. and Nishikawa, S-I., The murine mutation osteopetrosis in the coding region of the macrophage colony stimulating factor gene, Nature 345:442–444(1990).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Developmental and Molecular Biology and Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    Jeffrey W. Pollard

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  1. Baylor College of Medicine, Houston, Texas, USA

    Stanley R. Glasser  & Joy Mulholland  & 

  2. Hôpital Bicêtre, Bâtiment INSERM Gregory Pincus, Bicêtre, France

    Alexandre Psychoyos

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Pollard, J.W. (1994). Colony Stimulating Factor-1 in the Female Reproductive Tract During the Pre- and Peri-Implantation Periods. In: Glasser, S.R., Mulholland, J., Psychoyos, A. (eds) Endocrinology of Embryo-Endometrium Interactions. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1881-5_21

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