Hydrolysis of Phospholipids and Activation of Protein Kinase C for Intracellular Signalling

  • Shun-ichi Nakamura
  • Yoshinori Asaoka
  • Kouji Ogita
  • Yasutomi Nishizuka


Inositol phospholipid hydrolysis by phospholipase C was once thought to be the only mechanism to produce diacylglycerol that relays information of extracellular signals into intracellular events through activation of protein kinase C. It is becoming clear that agonist-induced hydrolysis of various membrane phospholipids, particularly choline phospholipid, by phospholipase A2 and phospholipase D also takes part in cellular responses such as cell proliferation and differentiation. Possibly, the members of the protein kinase C family may be activated differently by various combinations of phospholipid degradation products, and play each distinct roles in signal transduction for the control of various cellular functions.


Phorbol Ester Arachidonic Acid Release Detailed Experimental Condition Base Exchange Reaction Enzymological Property 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Shun-ichi Nakamura
    • 1
  • Yoshinori Asaoka
    • 2
  • Kouji Ogita
    • 1
  • Yasutomi Nishizuka
    • 1
    • 2
  1. 1.Dept. of BiochemistryKobe University School of MedicineKobeJapan
  2. 2.Biosignal Research CenterKobe UniversityKobeJapan

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