Skip to main content

Male-Mediated Developmental Toxicity: Paternal Exposures and Childhood Cancer

  • Chapter

Part of the book series: Reproductive Biology ((RBIO))

Abstract

Investigation of the epidemiology of cancers of childhood provides some unique challenges, and offers the prospect of deeper understanding of the process of carcinogenesis as it applies to both adults and children. It can also be a frustrating and unrewarding pursuit. The question of the effect of paternal exposure on risk of cancer in an offspring illustrates both the fascination of this field, and its limitations.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Buckley, J.D., Sather, H., Ruccione, K., Rogers, P.C.J., Haas, J.E., Henderson, B.E., Hammond, G.D. A case-control study of risk factors for hepatoblastoma. A report from the Childrens Cancer Study Group. Cancer 1989; 64:1169–1176.

    Article  PubMed  CAS  Google Scholar 

  • Buckley, J.D., Robison, L.L., Swotinsky, R., Garabrant, D., LeBeau, M., Nesbit, M.E., Odom, L., Peters, J., Woods, W.G., Hammond, G.D. Occupational exposures of parents of children with acute nonlymphocytic leukemia. Cancer Res. 1989; 49:4030–4037.

    PubMed  CAS  Google Scholar 

  • Fabia, J., Thuy, T.D. Occupation of father at time of birth of children dying of malignant diseases. Br. J. Prev. Soc. Med. 1974; 28:98–100.

    PubMed  CAS  Google Scholar 

  • Gold, E., Gordis, L., Tonascia, J., Szklo, M. Risk factors for brain tumours in children. Am J of Epidemiol. 1979; 109:309–319.

    CAS  Google Scholar 

  • Hemminki, K., Saloniemi, I., Salonen, T., Partanen, T., Vainio, H. Childhood cancer and parental occupation in Finland. J. Epidemiol. Community Health 1981; 35:11–15.

    Article  PubMed  CAS  Google Scholar 

  • Hicks, N., Zack, M., Caldwell, G.G., Fernbach, D.J., Falletta, J.M. Childhood cancer and occupational radiation exposure in parents. Cancer 1984; 53:1637–1643.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, C.C., Annegers, J.F., Frankowski, R.F., Spitz, M.R., Buffler, P.A. Childhood nervous system tumors—an evaluation of the association with paternal occupational exposure to hydrocarbons. Am. J. Epidemiol. 1987; 126:605–613.

    PubMed  CAS  Google Scholar 

  • Kantor, A.F., McCrea-Curnen, M.G., Meigs, J.W., Flannery, J.T. Occupations of fathers of patients with Wilms’ tumour. J. Epidemiol. Community Health 1979; 33:253–256.

    Article  PubMed  CAS  Google Scholar 

  • Leary, L.M., Hicks, A.M., Peters, J.M., London, S. Parental occupational exposures and risk of childhood cancer: a review. Am. J. Ind. Med. 1991; 20:17–35.

    Article  Google Scholar 

  • Lowengart, R.A., Peters, J.M., Cicioni, C., Buckley, J., Bernstein, L., Preston-Martin, S., Rappaport, E. Childhood leukemia and parent’s occupational and home exposures. JNCI 1987; 79:39–46.

    PubMed  CAS  Google Scholar 

  • McKinney, P.A., Cartwright, R.A., Saiu, J.M.T., Mann, J.R., Stiller, C.A., Draper, G.J., Hartley, A.L., Hopton, P.A., Birch, J.M., Waterhouse, J.A.H., and Johnston, H.E. The inter-regional epidemiological study of childhood cancer (IRESCC): a case control study of aetiological factors in leukaemia and lymphoma. Arch. Dis. Child. 1987; 62:279–287.

    Article  PubMed  CAS  Google Scholar 

  • Peters, J.M., Preston-Martin, S. Brain tumours in children and occupational exposure of parents. Science 1981; 213:235–237.

    Article  PubMed  CAS  Google Scholar 

  • Sanders, B.M., White, G.C., Draper, G.J. Occupations of fathers of children dying from neoplasms. J. Epidemiol. Comm. Health 1981; 35:245–250.

    Article  CAS  Google Scholar 

  • Savitz, D.A., Chen, J. Parental occupation and childhood cancer: review of epidemiologic studies. Environ. Health Perspect. 1990; 88:325–337.

    Article  PubMed  CAS  Google Scholar 

  • Shu, X.O., Gao, Y.T., Brinton, L.A., Linet, M.S., Tu, J.T., Zheng, W., Fraumeni, J.F. A population-based case-control study of childhood leukemia in Shanghai. Not published, 1987.

    Google Scholar 

  • Spitz, M.R., Johnson C.C. Neuroblastoma and paternal occupation. Am. J. Epidemiol. 1985; 121:924–929.

    PubMed  CAS  Google Scholar 

  • Vianna, N.J., Kovasznay B, Polan A, Ju C. Infant leukemia and paternal exposure to motor vehicle exhaust fumes. J. Occup. Med. 1984; 26:679–682.

    PubMed  CAS  Google Scholar 

  • Wilkins, J.R., Sinks T.H. Paternal occupation and Wilms’ tumour in offspring. J. Epidemiol. Community Health 1984; 38:7–11.

    Article  PubMed  Google Scholar 

  • Wilkins, J.R., Sinks, T.H. Parental occupation and intracranial neoplasms of childhood: results of a case-control interview study. Am. J. Epidemiol. 1990; 132:275–292.

    PubMed  Google Scholar 

  • Wilkins, J.R., Koutras, R.A. Paternal occupation and brain cancer in offspring: a mortality-based case-control study. Am. J. Ind. Med. 1988; 14:299–318.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Buckley, J. (1994). Male-Mediated Developmental Toxicity: Paternal Exposures and Childhood Cancer. In: Olshan, A.F., Mattison, D.R. (eds) Male-Mediated Developmental Toxicity. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1877-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1877-8_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5764-3

  • Online ISBN: 978-1-4615-1877-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics