Influence of Perflubron Vapor on Pulmonary Gas Trapping and Surface Tension after Intravenous Pfob-Emulsion Administration

  • B. Lachmann
  • R. J. Houmes
  • N. S. Faithfull
  • W. Erdmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 361)

Abstract

Use of intravenous injection of perfluorocarbon emulsions in rabbits has been reported to result in increased collapsing volume after post-mortem thoracotomy [1]. This effect has been called pulmonary gas trapping (PGT) and has been associated with an increase in intraalveolar micro-bubbles due to “gas osmosis” [2]. Inhaling the vaporized form of perflubron (perfluorooctyl bromide [PFOB] Alliance Pharmaceutical Corp., San Diego, CA) has been shown to reduce this PGT effect. As histologic evidence for these micro-bubbles is hard to obtain, we postulated that the presence of the micro-bubbles may be related to an increased surfactant activity. The aim of this study was to investigate the hypothesis that the increased collapsing volume is associated with increased surfactant activity.

Keywords

Surfactant Bromide Perfluorocarbon Perflubron PFOB 

References

  1. 1.
    Clark LC, Response of the rabbit lung as a criterion of safety for perfluorocarbon breathing and blood substitutes. Biomat Art Cells & Immob Biotech 1992; 20:2–4, 1085–1099.CrossRefGoogle Scholar
  2. 2.
    Schutt E, Barber P, et al, Proposed mechanism of Pulmonary Gas Trapping (PGT) following intravenous perfluorocarbon emulsion administration. Presented at: Vth ISBS, San Diego, CA, USA. March 1993.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • B. Lachmann
    • 1
  • R. J. Houmes
    • 1
  • N. S. Faithfull
    • 2
  • W. Erdmann
    • 1
  1. 1.Department of AnesthesiologyErasmus University, RotterdamThe Netherlands
  2. 2.Department of Medical ResearchAlliance Pharmaceutical CorpSan DiegoUSA

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