Abstract
When anesthetized dogs were given the α-adrenergic blocking agent phenoxybenzamine and then made hypoxic, their ability to extract oxygen from a supply that was limiting to oxygen uptake was significantly less than in unblocked animals (Cain, 1978). This was evident by a lower slope of the line relating O2 uptake to oxygen delivery as O2 uptake became linearly dependent upon O2 delivery. The reason for the lesser efficiency in extracting oxygen by the α-blocked animals was postulated to depend upon the loss of vasoconstrictor tone. The hypothesis that was offered stated that a vigorous constrictor tone was necessary in hypoxia so that blood flow in excess to need would not occur in any organ system or tissue. The constrictor tone in areas where O2 demand exceeded O2 supply would then be offset by the production of vasodilator metabolites in proportion to the imbalance of supply and demand. In this manner, blood flow and O2 delivery would be matched to local O2 need so that O2 would not be shunted through areas that were overperfused relative to their O2 uptake.
Deceased July 29,1933
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References
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© 1994 Springer Science+Business Media New York
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Winn, M.J., Vallet, B., Cain, S.M., Curtis, S.E., Chapler, C.K., King, C.E. (1994). Critical Oxygen Extraction in Dog Hindlimb after Inhibition of Nitric Oxide Synthase and Cyclooxygenase Systems. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_48
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