Abstract
It has been suggested that there is considerable heterogeneity of diffusion within cells and that oxygen diffuses unevenly across tissue, with more rapid diffusion in intracellular channels of high oxygen solubility (Longmuir, 1980). These oxygen channels are thought to be membranous structures within the cell with high lipid content, such as mitochondria and the sarcoplasmic reticulum in striated muscle. There is evidence from comparative physiology that higher maximal oxygen uptake capacity in aerobic animals is achieved by greater mitochondrial content (Weibel et al., 1992). This, combined with the fact that endurance training preferentially increases the volume of subsarcolemmal mitochondria and lipid droplets (Hoppeler and Billeter, 1991), suggests that higher lipid content and nonuniform mitochondrial distribution play an important role in cellular oxygen transport.
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Dutta, A., Popel, A.S. (1994). Analysis of Tissue Diffusivity Using Mathematical Models. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_3
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_3
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