Abstract
In the group of artificial oxygen carriers perfluorochemicals (PFCs) can serve as contrast agents for 19F-NMR imaging. However, some of the PFCs were accused for a long-term retention by organs of the reticuloendothelial system (RES), especially in liver and spleen (Lutz 1985). Thus the question arose how far PFCs of the second generation would share this disadvantage.
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References
Adam G, Gunther RW, Schiffer C, Gortz H, Prescher A, Scherer K, 1992. Computed tomographic enhancement of the liver, liver abscesses, spleen, and major vessel with perfluorooctylbromide emulsion. Invest. Radiol. 27: 698–705
Eidelberg D, Johnson G, Barnes D, Tofts PS, Delpy D, Plummer D, McDonald WI, 1988. 19F NMR imaging of blood oxygenation in the brain. Mag. Res. in Med. 6: 344–352
Freeman DM, Muller HH, Hurd RE, Young SW, (1988). Rapid 19F Magnetic resonance imaging of perfluorooctyl bromide in vivo. Magn. Reson. Imaging 6:61–64
Haase A, 1990. Snapshot FLASH MRI. Application to Tl, T2, and chemical-shift imaging. Magn. Reson. Med. 13: 77–89
Jäger LJE, Lutz J, 1993a. Plasma enzyme pattern after administration of different doses of perfluorooctylbromide in rats. Pfliigers Arch. 422 [Suppll R 117
Jäger LJE, Lutz J, 1993b. Phagocytosis of colloidal carbon after administration of artificial oxygen carriers of first and second generation. Advances in Exp. Med. & Biol., Plenum Press, New York (in press)
Jakob PM, Kotitschke K, Haase A, 1992. STEP pulse: A new presaturation pulse and its application. SMRM 11th Annual Meeting, Book of Abstracts 2: 3910
Jakob PM, Matthaei D, Stodal H, Brinck U, Haase A, 1993. Simultaneous preparation of inversion recovery T1 and chemical shift selective contrast using snapshotFLASH-MRI. MAGMA 1: 77–82
Lutz J, 1985. Effect of perfluorochemicals on host defense, especially on the reticuloendothelial system. In: “Perfluorochemical Oxygen Transport”. K.K. Tremper ed., Little, Brown & Co. Boston 1985 p.63–93
Lutz J, Metzenauer P, 1980. Effects of potential blood substitutes (perfluorochemicals) on rat liver and spleen. Pfliigers Arch. 387: 175–181
Lutz J, Stark M, 1987. Half life and changes in the composition of a perfluorochemical emulsion within the vascular system of rats. Pfiligers Arch. 410: 181–184
Mason RP, Shukla H, Antich PP, 1992. OxygentTM: a novel probe of tissue oxygen tension. Biomat. Art. Cells, Immob. Biotechn. 20, 929–932
Mason RP, Shukla H, Antich PP, 1993. In vivo oxygen tension and temperature: Simultaneous determination using 19F NMR spectroscopy of perfluorocarbon. Magn. Reson. Med. 29: 296–302
Mattrey RF, Long DM, Peck WW, Slutsky RA, Higgins CB, 1984. Perfluoroctylbromide as a blood pool contrast agent for liver, spleen, and vascular imaging in computed tomography. J. Comput. Assist. Tomogr. 8: 739–744
Meyer KL, Carvlin MJ, Mukherji B, Sloviter HA, Joseph PM, 1992. Fluorinated blood substitute retention in the rat measured by fluorine-19 magnetic resonance imaging. Invest. Radiol. 27: 620–627
Naito R, Yokoyama K, 1978. Perfluorochemical blood substitutes. Technical Information Ser. 5, The Green Cross Corp. Osaka Japan
Nöth U, Jäger LJE, Lutz J, Haase A, 1993. Fast 19-F-NMR imaging using PFOB as contrast agent. 10th Ann. Scient. Meeting Europ. Soc. MR in Med. & Biol. Book of Abstracts: 448
Nöth U, Jäger LJE, Lutz J, Haase A, 1994. Fast 19-F-NMR imaging in vivo using FLASH-MRI. Mag. Reson. Imaging 12 (in press)
Ratner AV, Hurd R, Muller HH, Bradley-Simson B, Pitts W, Shibata D, Sotak C, Young SW, 1987. 19F magnetic resonance imaging of the reticuloendothelial system. Magn. Res. Med. 5: 548–554
Ratner AV, Muller HH, Bradley-Simson B, Johnson DE, Hurd RE, Sotak C, Young SW, 1988. Detection of tumors with 19F magnetic resonance imaging. Invest. Radiol. 23:361–364
Riess J, LeBlanc M, 1982. Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and other biomedical applications. Pure & Appl. Chem. 54:2383–2406
Yokoyama K, Yamanouchi K, Ohyanagi H, Mitsuno T, 1978. Fate of perfluorochemicals in animals after intravenous injection or hemodilution with their emulsions. Chem. Pharm. Bull. 26: 956–966
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Jäger, L.J.E., Nöth, U., Haase, A., Lutz, J. (1994). Half-Life of Perfluorooctylbromide in Inner Organs Determined by Fast 19F-NMR Imaging. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_17
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_17
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