Intravenous Potassium Infusion Reverses Skeletal Muscle Fatigue
Intracellular potassium loss has been implicated as the basis of skeletal muscle fatigue (1). A decrease in the cell membrane K+ gradient diminishes the action potential. In turn, Ca++ release decreases and a smaller tension is developed. The largest K+ losses have been reported during high-intensity, dynamic exercise. The purpose of this study was to determine the effect of KC1 infusion on hindlimb forces in rabbits.
- 1.Sjogaard G. Exercise-induced muscle fatigue: The significance of potassium. Acta Physiol Scand 1990;suppl 593:1–63Google Scholar