Abstract
Cathepsin E is a non-lysosomal, non-secretory, intracellular aspartic proteinase. Its cellular distribution is variable between species but includes the stomach, spleen, red and white blood cells and the skin. The physiological role of this enzyme is unclear, but it has been implicated in a number of vital processes. Possible functions include, biogenesis of the potent vasoconstrictor peptide, endothelin (1), antigen processing (2) and aiding the infection of cells by the human immunodeficiency virus (3). Cathepsin E, being neither secretory nor lysosomal, is difficult to isolate in reasonable amounts and, due to its physiological importance, is an ideal candidate for cloning and expression in a heterologous host.
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Hill, J., Montgomery, D., Kay, J. (1995). Recombinant Human Cathepsin E. In: Takahashi, K. (eds) Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 362. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1871-6_38
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DOI: https://doi.org/10.1007/978-1-4615-1871-6_38
Publisher Name: Springer, Boston, MA
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