Identification of Five Molecular forms of Cathepsin D in Bovine Milk
Bovine milk contains a wide range of enzymes (1), including zymogens for the proteolytic enzymes plasmin and cathepsin D (2,3). Inside the cell procathepsin D is rapidly processed to the mature cathepsin D found in lysosomes (4). Resulting from the limited availability of procathepsin D the activation process leading to cathepsin D has been less clarified than e.g. the activation pathways of pepsinogen.
KeywordsCarbohydrate Titration Sodium Chloride Prefix Coomassie
Unable to display preview. Download preview PDF.
- 10.T. Takahashi and J. Tang, Cathepsin D from porcine and bovine spleen in “Meth. enzymol.” 80:565, Colowick and Lorand (eds.), Academic Press, New York (1981).Google Scholar
- 12.P. Metcalf and M. Fusek, Two crystal structures for cathepsin D: the lysosomal targeting signal and active site, EMBO J. 12:1293(1993).Google Scholar