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New Methods for Diagnosis and Epidemiological Studies of Tuberculosis based on PCR and RFLP

  • Carlos Martín
  • Sofía Samper
  • Isabel Otal
  • Pilar Asensio
  • Rafael Goméz-Lus
  • Gabriela Torrea
  • Brigitte Gicquel
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 75)

Abstract

Tuberculosis is a major cause of morbidity and mortality in the world today, particularly in developing and tropical countries. More than one billion individuals are infected with Mycobacterium tuberculosis, and more than 3.5 million people die anually. After years of declining case rates, tuberculosis has returned as a major public health problem in the United States and Europe. The epidemiology of tuberculosis is changing dramatically due to socio-economical problems, the HIV pandemic and the emergence of drug-resistant strains. New methods, based on polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP), for the diagnosis and epidemiological studies of tuberculosis are of critical importance for the development of effective control strategies for the disease.

Keywords

Restriction Fragment Length Polymorphism Mycobacterium Tuberculosis Mycobacterium Bovis Mycobacterial Species Effective Control Strategy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Carlos Martín
    • 1
  • Sofía Samper
    • 1
  • Isabel Otal
    • 1
  • Pilar Asensio
    • 1
  • Rafael Goméz-Lus
    • 1
  • Gabriela Torrea
    • 2
  • Brigitte Gicquel
    • 2
  1. 1.Unidad Microbiología Facultad de MedicinaUniversidad ZaragozaSpain
  2. 2.Unité Génétique MycobactérienneInstitut PasteurParisFrance

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