Skip to main content
SpringerLink
Log in

Experimentally-Induced Duodenal Ulcers in Rats are Associated with a Reduction of Gastric and Duodenal Calcitonin Gene-Related Peptide-Like Immunoreactivity

  • Chapter
Neuroendocrinology of Gastrointestinal Ulceration

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 2))

Abstract

Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts1. CGRP-like immunoreactivity (li) is widely distributed in the rat gastrointestinal tract2 and high concentrations of CGRP-li have been found in the rat stomach and duodenum2. The absence of CGRP-li in endocrine cells3 at these levels suggests that it is more important as a neuropeptide than as a circulating hormone. Exogenous CGRP was reported to inhibit gastric acid secretion4, increase gastric blood flow5,6, induce a relaxation of duodenal smooth muscle7, act as a potent antiulcer against experimentally-induced gastroduodenal ulcers8. All these effects have been shown to be protective in duodenal ulcers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M.G. Rosenfeld, J.J. Mermod, S.G. Amara, L.W. Swanson, P.E. Sawchenko, J. Rivier, W.W. Vale,and R.M. Evans, Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing, Nature. 304:129 (1983).

    Article  PubMed  CAS  Google Scholar 

  2. C. Sternini, J.R. Reeve, and N. Brecha, Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal capsaicin-treated rats, Gastroenterology. 93:852 (1987).

    PubMed  CAS  Google Scholar 

  3. G.J. Dockray, Regulatory peptides and the neuroendocrinology of gut-brain relations, Quart J Exp Physiol 73:703 (1988).

    CAS  Google Scholar 

  4. Y. Taché, T. Pappas, M. Lauffenburger, Y. Goto, J.H. Walsh, and H. Debas, Calcitonin generelated peptide: potent peripheral inhibitor of gastric acid secretion in rats and dogs, Gastroenterology. 87:344 (1984).

    PubMed  Google Scholar 

  5. P. Holzer, and P.H. Guth, Neuropeptide control of rat gastric mucosal blood flow, Circ Res.68:100 (1991).

    Article  PubMed  CAS  Google Scholar 

  6. I. Th. Lippe, M. Lorbach, and P. Holzer, Close arterial infusion of calcitonin gene-related peptide (CGRP) into the rat stomach inhibits aspirin-and ethanol-induced haemorrhagic damage, Regul Peptides. 26:35 (1989).

    Article  CAS  Google Scholar 

  7. C.A. Maggi, S. Manzini, S. Giuliani, P. Santicioli, and A. Meli, Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic, non-cholinergic neurons, Naunyn-Schmiedeberg’s Arch Pharmacol. 334:172 (1986).

    Article  CAS  Google Scholar 

  8. S. Evangelista, M. Tramontana, and C.A. Maggi, Pharmacological evidence for the involvement of multiple calcitonin gene-related peptide (CGRP) receptors in the antisecretory and antiulcer effect of CGRP in rat stomach, Life Sci. 50:PL13 (1992).

    Article  PubMed  CAS  Google Scholar 

  9. Y. Ishi, Y. Fuji, and M. Homma, Gastric acid stimulating action of cysteamine in the rat, Eur J Pharmacol. 36:331 (1976).

    Article  Google Scholar 

  10. S. Szabo, Mechanisms of mucosal injury in the stomach duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies, Scand J Gastroenterol. 22(Suppl. 127):21 (1987).

    Article  Google Scholar 

  11. S. Evangelista, D. Renzi, P. Mantellini, C. Surrenti, and A. Meli, Duodenal ulcers are associated with a depletion of duodenal calcitonin gene-related peptide-like immunoreactivity in rats, Eur J Pharmacol. 164:389 (1989).

    Article  PubMed  CAS  Google Scholar 

  12. S. Evangelista, C.A. Maggi, S. Giuliani, and A. Meli, Further studies on the role of the adrenals in the capsaicin-sensitive “gastric defence mechanism”, Int J Tissue React. 10:253 (1988).

    PubMed  CAS  Google Scholar 

  13. P. Holzer, Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons, Pharmacol Rev. 43:143 (1991).

    PubMed  CAS  Google Scholar 

  14. I. Th. Lippe, M.A. Pabst, and P. Holzer, Intragastric capsaicin enhances rat gastric acid elimination and mucosal blood flow by afferent nerve stimulation, Br J Pharmacol. 96:91 (1989).

    Article  PubMed  CAS  Google Scholar 

  15. K. Ohe, Y. Miura, Y. Taoka, Y. Osakada, and A. Miyoshi, Cysteamine-induced inhibition of mucosal and pancreatic alkaline secretion in rat duodenum, Dig Dis Sci. 33:330 (1988).

    Article  PubMed  CAS  Google Scholar 

  16. G. Pihan, T.J. Kline, N.K. Hollenberg, and S. Szabo, Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat, Gastroenterology. 88:989 (1985).

    PubMed  CAS  Google Scholar 

  17. Y. Kurebayashi, M. Asano, T. Hashizume, and A. Akashi, Changes in duodenal mucosal blood flow and mucus glycoprotein content during cysteamine-induced duodenal ulceration in rats, Arch Int Pharmacodyn Ther. 276:152 (1985).

    PubMed  CAS  Google Scholar 

  18. T.J. Kline, G. Pihan, and S. Szabo, Biphasic effect of duodenal ulcerogens on gastric emptying in the rat, Dig Dis Sci. 33:926 (1988).

    Article  PubMed  CAS  Google Scholar 

  19. K. Takeuchi, O. Furukawa, H. Tanaka, and S. Okabe, A new model of duodenal ulcers induced in rats by indomethacin plus histamine, Gastroenterology. 90:636 (1986).

    PubMed  CAS  Google Scholar 

  20. S. Szabo, and S. Reichlin, Somatostatin in rat tissue is depleted by cysteamine, Endocrinology.109:2255 (1981).

    Article  PubMed  CAS  Google Scholar 

  21. O.U. Scremin, F.W. Leung, and P.H. Guth, Pathogenesis of duodenal ulcer in the rat: dissociation of acid load and blood flow, Am J Physiol. 256:G1058 (1989).

    PubMed  CAS  Google Scholar 

  22. P. Holzer, and W. Sametz, Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurones, Gastroenterology. 91:975 (1986).

    PubMed  CAS  Google Scholar 

  23. C.A. Maggi, S. Evangelista, L. Abelli, V. Somma, and A. Meli, Capsaicin-sensitive mechanisms and experimentally induced duodenal ulcers in rats, J Pharm Pharmacol. 39:559 (1987).

    Article  PubMed  CAS  Google Scholar 

  24. M. Tramontana, D. Renzi, C. Panerai, C. Surrenti, F. Nappi, L. Abelli, and S. Evangelista,Capsaicin-like effect of resiniferatoxin in the rat stomach, Neuropeptides. 26:29 (1994).

    Article  PubMed  CAS  Google Scholar 

  25. P. Holzer, M.A. Pabst, and I. Th. Lippe, Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa, Gastroenterology. 96:1425 (1989).

    PubMed  CAS  Google Scholar 

  26. P. Holzer, B.M. Peskar, B.A. Peskar, and R. Amann, Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach, Neurosci Lett. 108:195 (1990).

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Stefano Evangelista
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paola Mantellini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniela Renzi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Medical School, Boston, Massachusetts, USA

    Sandor Szabo

  2. Irvine VA Medical Center, University of California, Long Beach, California, USA

    Sandor Szabo

  3. Center for Ulcer Research and Education, University of California, Los Angeles, California, USA

    Yvette Taché

  4. University of Manitoba, Winnipeg, Manitoba, Canada

    Gary B. Glavin

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Evangelista, S., Mantellini, P., Renzi, D. (1995). Experimentally-Induced Duodenal Ulcers in Rats are Associated with a Reduction of Gastric and Duodenal Calcitonin Gene-Related Peptide-Like Immunoreactivity. In: Szabo, S., Taché, Y., Glavin, G.B. (eds) Neuroendocrinology of Gastrointestinal Ulceration. Hans Selye Symposia on Neuroendocrinology and Stress, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1867-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1867-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5759-9

  • Online ISBN: 978-1-4615-1867-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation