Abstract
The stomach has many physiological functions, such as acid and pepsin secretion, mucus production and motility, which are supposed to be regulated by gastric mucosal blood flow. Therefore, blood flow is an extremely important defensive factor for the gastric mucosa. The present study was designed to elucidate the role of mucosal blood flow in the development of acute gastric mucosal lesions (AGML) after burn stress. Gastric mucosal blood flow and microcirculatory disturbance were investigated. Also, we examined the influence of gastric mucosal blood flow on the alternation of acid and pepsin activity, energy metabolism and mucus production (Hexosamine content).
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References
J.B. Dekanski, A. MacDonald, and P. Sacra, Effect of fasting stress and drugs on glycoprotein synthesis in the rat. Brit J Pharmacol. 55:387 (1975).
O.W. Neuhaus, and M. Letzring, Determination of hexosamines in conjunction with electrophoresis on starch, Anal Chem. 29:1230 (1957).
D.E. Atkinson, The energy charge of the adenylate pool as a regulatory parameter, interaction with feedback modifiers, Biochemistry. 7:4030 (1968).
H. Shay, The pathologic physiology of gastric and duodenal ulcer, Bull N Y Acad Med. 20:264 (1944).
M. Kitajima, R.D. Wolfe, R.L. Trelstad et al., Gastric mucosal lesions after burn injury. Relationship to H+ back diffusion and the microcirculation, J Trauma. 18:644 (1978).
P.H. Guth, Gastric blood flow in restraint stress, Amer J Dig Dis. 17:807 (1972).
M. Kitajima, Y. Ikeda, and H. Torii, Acute gastric mucosal lesions following burn injury: relationship to acid and pepsin output and gastric microcirculation, in: “New Trends in Peptic Ulcer and Chronic Hepatitis,” Japanese Society of Gastroenterology, ed., Exerpta Medica,Tokyo (1987).
I. Joris, U. DeGirolami, K. Wortham et al., Vascular labelling with monastral blue B, Stain Technology. 57:177 (1982).
S. Szabo, J.S. Trier, A. Brown et al., Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat, Gastroenterology. 88:228 (1985).
M. Kitajima, and H. Ito, Gastric mucosal blood flow and energy metabolism in stress, in: “Microcirculation Annual 1985,” M. Tsuchiya, ed., Excerpta Medica, Tokyo (1985).
R. Menguy, and Y.E. Masters, Gastric mucosal energy metabolism and stress ulceration, Ann Surg. 180:538 (1974).
M. Kitajima, J.R. Allsop, R.L. Trelstadt et al., Experimental studies on stress ulcer of the stomach following thermal injury with special reference to H+ back diffusion and microcirculation,Gastroenterol Jpn. 13:175 (1978).
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Kitajima, M., Yoshida, M., Otani, Y., Kumai, K. (1995). The Development of Acute Gastric Mucosal Lesions Following Burn Stress. In: Szabo, S., Taché, Y., Glavin, G.B. (eds) Neuroendocrinology of Gastrointestinal Ulceration. Hans Selye Symposia on Neuroendocrinology and Stress, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1867-9_5
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DOI: https://doi.org/10.1007/978-1-4615-1867-9_5
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4615-1867-9
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