Abstract
Peptic ulceration including acute erosions is a multifactorial disease involving well-known factors such as trauma, stress, sepsis, hemorrhagic shock, burns, pulmonary and liver diseases1–9 and drugs such as reserpine10, epinephrine11–13, nonsteroidal antiinflammatory drugs7, steroids and other chemicals14.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
A.C. Ivy, M.I. Grossman, and W.H. Blachrach, “Peptic Ulcer”, The Blakiston Company, Philadelphia (1950).
C.J. Pfeiffer, “Peptic Ulcer”, Lippincott Company-Copenhagen, Munsgaard, Philadelphia (1971).
T.H. Gheorghiu, “Experimental Ulcer. Models, Methods and Clinical Validity”, Gerhard Witzstrock Publishers, Baden-Baden, Brussels, Cologne (1975).
Gy. Mózsik, and T. Jávor, “Progress in Peptic Ulcer”, Akadémiai Kiadó, Budapest (1976).
Gy. Mózsik, O. Hanninen, and T. Jávor, “Advances in Physiological Sciences, Vol.29,Gastrointestinal Defence Mechanisms”, Pergamon Press-Akadémiai Kiadó, Oxford, Budapest (1981).
S. Umehara, and H. Ito, “Advances in Experimental Ulcer”, International Conference on Experimental Ulcer, Tokyo (1972).
K.D. Rainsford, and G.P. Velo, “Side Effects of Antiinflammatory Analgetic Drugs”, Raven Press, New York (1987).
S. Szabo, and Gy. Mózsik, “New Pharmacology of Ulcer Disease”, Elsevier Sciences Publishers, New York (1987).
S. Szabo, and C.J. Pfeiffer, “Ulcer Disease: New Aspects of Pathogenesis and Pharmacology”, CRC Press, Boca Raton (1989).
Gy. Mózsik, L. Nagy, I. Patty, and F. Tárnok, Cellular energy systems and reserpine ulcer, Acta Physiol Hung. 62:107 (1983).
S. Sethbhakdi, C.J. Pfeiffer, and J.L.A. Roth, Gastric mucosal ulceration following vasoactive agents. A new experimental model, Amer J Dig Dis. 15:261 (1970).
S. Sethbhakdi, J.L.A. Roth, and C.J. Pfeiffer, Gastric mucosal ulceration after epinephrine. A study of etiologic mechanisms, Amer J Dig Dis. 15:1055 (1970).
Gy. Mózsik, M. Fiegler, L. Nagy, I. Patty, and F. Tárnok, Gastric and small intestinal energy metabolism in mucosa, in: “Advances in Physiological Sciences, Vol.29, Gastrointestinal Defence Mechanisms”, Gy. Mózsik, O. Hanninen, T.Jávor, eds., Pergamon Press-Akadémiai Kiadó, Oxford, Budapest (1981).
A. Robert, J.E. Nemazis, C. Lanchaster, and A.J. Hanchar, Cytoprotection by prostaglandins in rats. Prevention of gastric mucosal necrosis by alcohol, HC1, NaOH, hypertonic NaCl and thermal injury, Gastroenterology. 77:433 (1979).
A. Allen, G. Flemström, A. Garner, W. Silen, and L.A. Turnberg, “Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract”, Raven Press, New York (1984).
Gy. Mózsik, A. Pár, and A. Bertelli, “Recent Advances in Gastrointestinal Cytoprotection”,Akadémiai Kiadó, Budapest (1984).
Gy. Mózsik, T. Jávor, M. Kitajima, C.J. Pfeiffer, K.D. Rainsford, L. Simon, and S. Szabó,Advances in gastrointestinal cytoprotection: topics 1981, Acta Physiol Hung. 73:111 (1989).
K. Chaudhury, and E.D. Jacobson, Prostaglandin cytoprotection of gastric mucosa,Gastroenterology. 74:59 (1978).
Gy. Mózsik, F. Morón, M. Fiegler, T. Jávor, L. Nagy, I. Patty, and F. Tárnok, Membrane-bound ATP-dependent energy systems and gastric cytoprotection by prostacyclin, atropine and cimetidine, Int J Tiss Reac. 5:263 (1983).
Gy. Mózsik, L. Lovász, G. Kutor, L. Nagy, and F. Tárnok, Experimental evidence for cytoprotective effect of atropine on the rat gastric mucosa, Acta Med Acad Sci Hung. 37:401 (1980).
P.H. Guth, D. Aures, and G. Poulsen, Topical aspirin plus HC1 gastric lesions in the rat.Cytoprotective effect of prostaglandin, cimetidine and Probanthine, Gastroenterology. 76:88 (1979).
E. Martinotti, C. Bernardini, M. Del Tacca, M. Pellegrini, G. Soldani, and A. Bertelli, Gastric cytoprotection by pirenzepine is not mediated by catecholamines, Acta Physiol Hung. 64:219 (1984).
F. Morón, E. Cuesta, M. Bata, and Gy. Mózsik, Cytoprotective effect of cimetidine: experimental evidence in rat gastric mucosal lesion induced by intragastric administration of necrotizing agents.
S.J. Konturek, T. Radecki, T. Brzozowski, I. Piastucki, A. Dembinska Kiec, and A. Zmuda, Gastric cytoprotection by prostaglandins, ranitidine and probantine, Scand J Gastroent. 16:7 (1981).
S.J. Konturek, T. Radecki, T. Brzozowski, I. Piastucki, A.Dembinska Kiec, and A. Zmuda,Experimental studies on gastric cytoprotection by prostaglandins, antisecretory agents and epidermal growth factor, in: “Advances in Ulcer Disease”, K.H. Holtermüller, J.R. Malagelada, eds., Excepta Medica, Amsterdam, Oxford, Princeton (1980).
T. Jávor, M. Bata, G. Kutor, L. Lovász, Gy. Mózsik, and F. Tárnok, Gastric mucosal resistance to physical and chemical stress, in: “Advances in Physiol Sciences Vol.29. Gastrointestinal Defence Mechanisms”, Gy. Mózsik, O. Hanninen, T. Jávor, eds., Pergamon Press -Budapest, Akadémiai Kiadó, Oxford (1989).
T. Jávor, M. Bata, L. Lovász, F. Morón, L. Nagy, I. Patty, J. Szabolcs, F. Tárnok, Gy. Tóth, and Gy. Mózsik, Gastric cytoprotective effects of vitamin A and others carotenoids, Int J Tis Reac. 5:289 (1983).
I. Patty, J. Szabolcs, G. Deák, T. Jávor, P. Kenéz, L. Nagy, L. Simon, F.Tárnok, and Gy. Mózsik, Controlled trial of vitamin A therapy in gastric ulcer, Lancet II:876 (1982).
F. Morón, N. Barreras, M. Achong, L. Nagy, T. Jávor, and Gy. Mózsik, Cytoprotective effect of disodium chromoglycate (INTAL) in gastric lesions induced by several necrotizing agents in rats, Digestion. 31:172 (1985).
F. Morón, N. Barreras, M. Achong, T. Jávor, L. Nagy, and Gy. Mózsik, Cytoprotective effect of disodium chromoglycate (INTAL) on the gastric mucosal lesions induced by necrotizing agents in rats, in: “New Pharmacology of Ulcer Disease. Experimental and Therapeutic Approaches”, S. Szabó, Gy. Mózsik, eds., Elsevier Science Publishers, New York (1987).
I. Patty, Sz. Benedek, G. Deák, T. Jávor, P. Kenéz, F. Morón, L. Nagy, L. Simon, F. Tárnok,and Gy. Mózsik, Cytoprotective effect of vitamin A and its clinical importance in the treatment of patients with chronic gastric ulcer, Int J Tiss Reac. 5:301 (1983).
Gy. Mózsik, A. Bertelli, G. Deák, L. Nagy, I. Patty, L. Simon, F. Tárnok, and T. Jávor, Some aspects of the critical evaluation of peptic ulcer therapy in patients, Int J Clin Pharmacol Res. 5:447 (1985).
Gy. Mózsik, F. Morón, L. Nagy, Cs. Ruzsa, and F. Tárnok, Evidence of the gastric cytoprotective effects of vitamin A, atropine and cimetidine on the development of gastric mucosal damage produced by administration of indomethacin in healthy subjects, Int J Reac. 8:85 (1986).
I. Patty, F. Tárnok, L. Simon, G. Deák, Sz. Benedek, P. Kenéz, L. Nagy, and Gy. Mózsik, A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol,sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study), Acta Physiol Hung. 64:379 (1984).
L. Nagy, Gy. Nagy, I. Rácz, L. Simon, I. Solt, I. Patty, F. Tárnok, Gy. Mózsik, and T.Jávor, A controlled multicentre therapeutic trial to determine the efficacy of a novel antacid (Al-Mg-Hydrocarbonate) in duodenal ulcer, Int I Clin Pharmacol Res. 9:85 (1989).
I. Patty, G. Deák, T. Jávor, Gy. Mózsik, L. Nagy, and F. Tárnok, A controlled trial with De-Nol (tripotassium dicitrato bismuthate) in patients with gastric ulcer, Int J Tiss Reac. 5:397 (1983).
Gy. Mózsik, T. Jávor, A. Bertelli, “Recent Advances in Gastrointestinal Cytoprotection”,Akadémiai Kiadó, Budapest (1984).
Gy. Mózsik, T. Jávor, M. Kitajama, C.J. Pfeiffer,K.D. Rainsford, L. Simon, and S.Szabó, Advances in gastrointestinal cytoprotection: Topics 1987, Acta Physiol Hung. 73:111 (1989).
F. Morón, Gy. Mózsik, M. Bata, M. Lovász, G. Kutor, M. Fiegler, and T.Jávor, Ethanol-induced gastric mucosal damage in rats: prevention by prostacyclin, Acta Med Acad Sci Hung. 38:365 (1981).
Gy. Mózsik, M. Morón, and T. Jávor, Cellular Mechanisms of the development of gastric mucosal damage and of gastroprotection induced by prostacyclin in rats. A pharmacological study, Prostaglandins, Leucotrienes Med 9:71 (1982).
Gy. Mózsik, F. Morón, M. Fiegler, T. Jávor, L. Nagy, I. Patty, and F. Tárnok, Interactions between membrane-bound ATP-dependent energy systems, gastric mucosal damage produced by NaOH, hypertonic NaCl, HC1 and alcohol, and prostacyclin induced gastric cytoprotection in rats, Prostaglandins, Leucotrienes and Med. 12:423 (1983).
Gy. Mózsik, M. Fiegler, T. Jávor, F. Morón, L. Nagy, I. Patty, and F.Tárnok, Pharmacology and biochemistry of prostacycline-induced gastric cytoprotection on ethanol-induced gastric mucosal injury in rats, in:“Advances in Pharmacological Research and Practice, Vol.3. Prostanoids”, V. Kecskeméti, K. Gyires, G. Kovács, eds., Pergamon Press -Akadémiai Kiadó, Oxford, Budapest (1986).
Gy. Mózsik, and T. Jávor, A biochemical and pharmacological approach to the genesis of ulcer disease. I. A model study of ethanol-induced injury to gastric mucosa in rats, Dig Dis Sci. 33:92 (1988).
Gy. Mózsik, M. Garamszegi, T. Jávor, L. Nagy, G. Sutő, and Á. Vincze, A pharmacological approach to cellular mechanisms of PGI2-induced gastric cytoprotection on ethanol-induced gastric mucosal damage in rats, Acta Physiol Hung. 73:207 (1989).
T.A. Miller, Protective effects of prostaglandins against gastric acid mucosal damage: current knowledge of proposed mechanisms, Am J Physiol. 245:6601 (1983).
H. Shay, S.A. Komarov, S.S. Fels, D. Merance, M. Gruenstein, and H.A.Simplet, Gastroenterology.5:43 (1945).
K.M. Wallus, W. Pawlik, and S.J. Konturek, Prostacyclin-induced gastric mucosal vasodilatation and inhibition of acid secretion in the dog, Proc Soc Exp Med. 163:228 (1980).
M. Guslandi, Cytoprotection: so what? Dig Dis Sci. 27:1144 (1982).
F. Morón, Gy. Mózsik, T. Jávor, M. Fiegler, L. Nagy, I. Patty, and F. Tárnok, Membrane-bound ATP-dependent energy systems and the development of the gastric mucosal damage in rats produced by 0.2M NaOH, 25% NaCl, 0.6N HC1 and 96% ethanol, Int J Tiss Reac. 5:357 (1983).
Gy. Mózsik, B. Kiss, M. Krausz, and T. Jávor, A biochemical-cellular-morphological explanation for antiulcerogenic effects of parasympatholytics and of surgical vagotomy in Shay rats, Scand J Gastroent. 4:641 (1969).
Gy. Mózsik, and F. Vizi, Surgical vagotomy and stomach wall ATP and ADP in pylorus-ligated rats, Amer J Dig Dis. 22:1072 (1977).
Gy. Mózsik, M. Garamszegi, T. Jávor, G. Sütő, Á. Vincze, Gy. Tóth, and T. Zsoldos,Correlations between the oxygen free radicals, membrane-bound ATP-dependent energy systems irrelation to development of ethanol-and HCl-induced gastric mucosal damage and of β-carotene-induced gastric cytoprotection, in:“Free Radicals in Digestive Diseases”,M. Tsuckiya et al., eds., Elsevier Science Publishers, Amsterdam (1988).
Gy. Mózsik, M. Garamszegi, M. Fiegler, L. Nagy, G. Sütő, Á.Vincze, T.Zsoldos, and T.Jávor,Mechanisms of Mucosal Injury in the Stomach. I. Timesequence analysis of gastric mucosal membrane-bound ATP-dependent energy system, oxygen free radicals and appearance of gastric mucosal damage, in:“Medical, Biochemical and Chemical Aspects of Free Radicals”, O. Hayaishi, E. Niki, M. Kondo, T. Yoshikawa, eds., Elsevier Science Publishers, Amsterdam (1989).
Gy. Mózsik, M. Fiegler, M. Garamszegi, T. Jávor, L. Nagy, G. Sütő, Á.Vincze, Gy.Tóth, and T.Zsoldos, Mechanisms of gastric mucosal cytoprotection.I.Time-sequence analysis of gastric mucosal membrane-bound ATP-dependent energy systems, oxygen free radicals and macroscopically appearance of gastric cytoprotection by PGI2 and β-carotene in HCl-model of rats, in:“Medical, Biochemical and Chemical Aspects of Free Radicals”, O. Hayaishi, E. Niki, M. Kondo, T. Yoshikawa, eds., Elsevier Science Publishers, Amsterdam (1989).
G.Sütő, M.Garamszegi, T Jávor, Á.Vincze, and Gy.Mózsik, Similarities and differences in the cytoprotection induced by PGI2 and β-carotene in experimental ulcer, Acta Physiol Hung. 73:155 (1989).
Gy. Mózsik, and T. Jávor, Therapy of ulcers with sulfhydryl and non-sulfhydryl antioxidants, in: “Ulcer Disease: Investigation and Basis for Therapy”, E.A. Sabb, S. Szabó, eds., Marcel Dekkel Inc., New York, Basel, Hong Kong (1991).
S. Szabo, Role of sulfhydryls and early vascular lesions in gastric mucosal injury, Acta Physiol Hung.64:203 (1984).
S. Szabo, G. Pihan, and J.S. Trier, Alterations in blood vessels during gastric injury and protection,Scand J Gastroent. 21:Suppl.l25:92 (1986).
S. Szabo, Critical and timely review of the concept of gastric cytoprotection, Acta Physiol Hung.73:115 (1989).
F. Morón, Gy. Mózsik, and T. Jávor, Effects of cimetidine administered in cytoprotective and antisecretory doses on the membrane-bound ATP-dependent energy systems in the rat gastric mucosal lesions induced by HC1 in rats, Acta Physiol Hung. 64:293 (1984).
Gy. Mózsik, M. Bata, M. Fiegler, T. Jávor, L. Nagy, I. Patty, Gy. Tóth, and F. Tárnok,Interrelationships between the membrane-bound ATP-dependent energy systems of the gastric mucosa and the gastric cytoprotective effect of β-carotene on the development of gastric mucosal damage, Acta Physiol Hung. 64:301 (1984).
Gy. Mózsik, M. Fiegler, M. Garamszegi, T. Jávor, L. Nagy, G. Sütő, and Á. Vincze, Biochemical background of the development of gastric mucosal damage produced by intragastric administration of ethanol or HC1 in the rats, Dig Dis Sci. 33:906 (1988).
Gy. Mózsik, M. Fiegler, M. Garamszegi, T. Jávor, L. Nagy, G. Sütő, and Á. Vincze, PGI2 prevents the development of gastric mucosal damage, β-carotene stimulates the repair mechanisms in ethanol-induced gastric mucosal damage in the rats, Dig Dis Sci. 33:906 (1988).
Gy. Mózsik, Á. Király, M. Garamszegi, T. Jávor, L. Nagy, A. Németh, G. Sütő, and Á. Vincze,Gastric cytoprotection mediating in SH groups is failured by surgical vagotomy, Acta Physiol Hung. 75 (Suppl.):219 (1990).
B. Bódis, M. Balaskó, Zs. Csontos, O. Karádi, Á. Király, T. Jávor, and Gy. Mózsik, Changes of gastric mucosal prostaglandin contents in intact and vagotomized rats, without and with β-carotene treatment, Dig Dis Sci. 35:1015 (1990).
A. Király, M. Balaskó, B. Bódis, Zs. Csontos, O. Karádi, G. Sütő, Á. Vincze, T.Jávor, and Gy.Mózsik, Acute surgical vagotomy cause an increased vascular permeability to chemicals in the rat stomach, Dig Dis Sci. 35:1020 (1990).
M. Balaskó, B. Bódis, Zs. Csontos, O. Karádi, Á. Király, G. Sütő, Á. Vincze, T.Jávor, and Gy.Mózsik, Vagus and gastrointestinal defence in rats treated with indomethacin, Dig Dis Sci. 35:1015 (1990).
Gy. Mózsik, G. Sütő, and Á. Vincze, Correlations between the acute chemical and surgical vagotomy-induced gastric mucosal biochemistry in rats, J Clin Gastroenterol. 14(Suppl.l):S135 (1992).
Gy. Mózsik, Á. Király, M. Garamszegi, T. Jávor, L. Nagy, A. Németh, G. Sütő, and Á.Vincze,Mechanisms of vagal nerve in the gastric mucosal defence: unchanged gastric emptying and increased vascular permeability, J Clin Gastroenterol. 14(Suppl.l):S140 (1992).
Gy. Mózsik, Á. Király, G. Sütő, and Á. Vincze, ATP breakdown and resynthesis in the development of gastrointestinal mucosal damage and its prevention in animals and human, Acta Physiol Hung. 80:39 (1992).
Á. Vincze, Á. Király, G. Sütő, and Gy. Mózsik, Is acute surgical vagotomy an aggressor to gastric mucosa in pylorus ligated rats with and without indomethacin treatment?, Acta Physiol Hung. 80:195 (1992).
G. Sütő, Á. Király, Á. Vincze, and Gy. Mózsik, Effect of acute surgical vagotomy on the mucosal content of 6-keto-PGFlα, PGE2 and glutathione after intragastric 96% ethanol treatment in rats, Acta Physiol Hung. 80:205 (1992).
A. Király, G. Sütő, Á. Vincze, Gy. Tóth, Z. Matus, and Gy. Mózsik, Correlation between the cytoprotective effect of β-carotene and its gastric mucosal level in indomethacin (IND) treated rats with or without acute surgical vagotomy, Acta Physiol Hung. 80:213 (1992).
A. Király, G. Sütő, Á. Vincze, and Gy. Mózsik, Acute and chronic surgical vagotomy (SV) and gastric mucosal vascular permeability in ethanol treated rats, Acta Physiol Hung. 80:219 (1992).
Gy. Mózsik, O. Karádi, Á. Király, Z. Matus, G. Sütő, Gy. Tóth, and Á. Vincze, Vagal nerve and the gastric mucosal defense, J Physiol. (Paris) 87:329 (1993).
A. Vincze, Á. Király, G. Sütő, and Gy. Mózsik, Changes of gastric mucosal biochemistry in ethanol-treated rats with and without acute surgical vagotomy, J Physiol. (Paris) 87:339 (1993).
O. Karádi, Gy. Mózsik, Á. Király, G. Sütő, and Á. Vincze, Surgical vagotomy enhances the indomethacin-induced gastrointestinal mucosal damage in rats, Inflammopharmacology. in press (1993).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mózsik, G. et al. (1995). Role of the Vagal Nerve in the Development of Gastric Mucosal Injury and its Prevention by Atropine, Cimetidine, β-Carotene and Prostacyclin in Rats. In: Szabo, S., Taché, Y., Glavin, G.B. (eds) Neuroendocrinology of Gastrointestinal Ulceration. Hans Selye Symposia on Neuroendocrinology and Stress, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1867-9_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1867-9_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5759-9
Online ISBN: 978-1-4615-1867-9
eBook Packages: Springer Book Archive