Abstract
Neurotensin (NT) is a tridecapeptide which has been identified in the central nervous system of all vertebrate classes, having been originally isolated from bovine hypothalamus1,2,3. Using immunohistochemical techniques, NT has been identified within the substance of the substantia nigra (SN), pars compacta, and the ventral tegmental area (VTA)4,5,6,7,8. Recently, NT binding sites have been identified in the VTA with a dissociation content (Kd) of 9.3 ± 0.4 nm and the number of binding sites (Bm) of 86 ± 10 fm/mg protein9. The VTA is found in the mesolimbic dopamine (DA) system within the central nervous system. This mesolimbic system originates in the A8, A9 (SN), and A10 cell bodies, passes along the medial forebrain bundle, and terminates in the limbic structures such as nucleus accumbens (N.ACB), olfactory tubercle, and the amygdala.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R. Carraway, and S.E. Leeman, The isolation of a new hypotensive peptide, neurotensin from bovine hypothalami, J Biol Chem. 248:6854 (1973).
R. Carraway, and S.E. Leeman, Characterization of radioimmunoassayable neurotensin in the rat.Its distribution in the central nervous system, small intestine and stomach, J Biol Chem. 251:7045 (1976).
P.J. Manberg, W.W. Youngblood, C.B. Nemeroff et al., Regional distribution of neurotensin in human brain, J Neurochem. 38:1777 (1982).
G.R. Uhl, M.J. Kuhar, and S.H. Snyder, Neurotensin immunohistochemical localization in rat central nervous system, Proc Natl Acad Sci USA. 74:4059 (1977).
L. Jennes, W.E. Stumpf, and P.W. Kalivas, Neurotensin: Topographical distribution in rat brain by immunohistochemistry, J Comp Neurol. 210:211 (1982).
T. Hokfelt, B.J. Everitt, E. Theodorssen-Norheim et al., Occurrence of neuortensin-like immunoreactivity in subpopulations of hypothalamic, mesencephalic and medullary catecholamine neurons, J Comp Neurol. 222:543 (1984).
P.W. Kalivas, Neurotensin in the ventromedial mesencephalon of the rat: Anatomical and functional considerations, J Comp Neurol. 226:495 (1984).
P.C. Emson, M. Goedert, and P.W. Mantyh, Neurotensin-containing neurons. in: “Handbook of Chemical Neuroanatomy, Vol. 4, GABA and Neuropeptides in the CNS,” A. Bjorklund, T. Hokfelt, eds., Elsevier, Amsterdam (1985).
C. Dana, M. Vial, K. Leonard et al., Electron microscopic localization of neurotensin binding sites in the midbrain tegmentum of the rat, I. Ventral tegmental area and interfascicular nucleus. J Neurosci. 9:2247(1989).
F.B. Jolicoeur, G. DeMichele, A. Barbeau et al., Neurotensin affects hyperactivity but not stereotype induced by pre and post synaptic dopamingergic stimulation, Neurosci Biobehav Rev. 7: 385 (1983).
E.C. Griffiths, P. Slater, and V.A.D. Webster. Behavioral interactions between neurotensin and thyrotropin-releasing hormone in rat central nervous system, J Physiol. 320:90P (1981).
A. Reches, R.E. Burke, D.H. Jiang et al., Neurotensin interacts with dopaminergic neurons in rat brain, Peptides. 4:43 (1983).
P.W. Kalivas, L. Jennes, C.B. Nemeroff et al., Neurotensin: Topographical distribution of brain sites involved in hypothermia and antinociception, J Comp Neurol. 210:225 (1982).
Z. Li, P.C. Colony, J.H. Washington et al., Central neurotensin affects rat gastric integrity, prostaglandin E2 and blood flow, Am J Physiol 256:G226 (1989).
L. Xing, C. Balaban, J. Washington et al., Central neurotensin-induced mucosal protection is mediated by dopamine receptors in nucleus accumbens, Gastroenterology. A504 (abstract) (1988).
L. Xing, J.C. King, R.M. Bryan et al., Effect of neurotensin on regional cerebral glucose utilization in cold water-restrained rats, Am J Physiol. 258:G591 (1990).
T. Gati, and P.H. Guth, Mucosal lesions due to gastric distention in the rat, Am J Dig Dis. 22: 1083 (1977).
L.K. Pelligrino, A.X. Pellegrino, and A.J. Xushmen, “A Stereotaxis Atlas of the Rat Brain,”Plenum, New York, (1979).
R.M. Bryan, K.A. Keefer, and C. MacNeill, Regional cerebral glucose utilization during insulin-induced hypoglycemia in unanesthetized rats, J Neurochem. 46:1904 (1986).
R.A. Hawkins, A.M. Mans, D.W. Davis et al., Cerebral glucose use measured with (14C) glucose labeled in the 1, 2, or 6 position, Am J Physiol. 248:C170 (1985).
R.M. Bryan, R.A. Hawkins, A.M. Mans, et al., Cerebral glucose utilization in awake unstressed rats, Am J Physiol. 244:C270 (1983).
M. Hagerdal, J. Harp, and B.K. Siesjo, Effect of hypothermia upon organic and associated amino acids in rat cerebral cortex, J. Neurochem. 24:745 (1975).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kauffman, G.L., Xing, L., Bryan, R. (1995). Neurotensin Acts in the Mesolimbic Dopamine System to Affect Gastric Mucosal Function. In: Szabo, S., Taché, Y., Glavin, G.B. (eds) Neuroendocrinology of Gastrointestinal Ulceration. Hans Selye Symposia on Neuroendocrinology and Stress, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1867-9_16
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1867-9_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5759-9
Online ISBN: 978-1-4615-1867-9
eBook Packages: Springer Book Archive